Size-selective adhesion of calcium oxalate monohydrate crystals to lipid membranes
The retention of calcium oxalate monohydrate (COM) crystals on cell membranes is pivotal in kidney stone formation. However, the mechanisms underlying COM attachment to neutral lipid membranes remain unclear. In this study, we demonstrate that COM exhibits size-selective adhesion to fluid lipid memb...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-02, Vol.12 (9), p.2274-2281 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Cui, Ziyu Chin, Che-Lun Kurniawan, Akhtar Fikri Huang, Ching-Chun Huang, Ling-Ting Chao, Ling |
| description | The retention of calcium oxalate monohydrate (COM) crystals on cell membranes is pivotal in kidney stone formation. However, the mechanisms underlying COM attachment to neutral lipid membranes remain unclear. In this study, we demonstrate that COM exhibits size-selective adhesion to fluid lipid membranes composed of lipids with distinct sizes. Specifically, the (100) facet of COM induces the formation of new domains and establishes strong adhesion in the 18:1 (Δ9-Cis) PC (DOPC) membrane, while the (010) facet induces domains with strong adhesion in the 16:0-14:0 PC membrane. This selectivity is linked to the compatibility of the area per lipid in DOPC with the unit cell area of the (100) facet and the area per lipid in 16:0-14:0 PC with the (010) facet. Our Raman spectroscopic analyses reveal that the lipid acyl chains within these induced domains exhibit a higher degree of ordering compared to the typical fluid state of the membrane. This ordered structural alignment, combined with the lateral size-matching effect, suggests the potential formation of molecular arrays within the lipid bilayer that are in harmony with the lattice dimension of COM. To elucidate the strong adhesion between calcium oxalate and the phospholipid head group in the absence of a direct molecular structural correspondence, we propose that crystal water associated with COM can form hydrogen bonds with the phospholipid head group. Using structure visualization software, we demonstrate the feasibility of such hydrogen bonding networks. The formation of this network could serve to stabilize and enhance the attachment of COM to the lipid membrane. This mediation by water molecules offers a plausible explanation for the pronounced affinity at the interface.
Our findings demonstrate that calcium oxalate monohydrate crystals can size-selectively influence the organization of fluid phospholipid membranes and facilitate the size-selective adhesion, potentially
via
water-mediated hydrogen bonding. |
| doi_str_mv | 10.1039/d3tb02483k |
| format | Article |
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Our findings demonstrate that calcium oxalate monohydrate crystals can size-selectively influence the organization of fluid phospholipid membranes and facilitate the size-selective adhesion, potentially
via
water-mediated hydrogen bonding.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d3tb02483k</identifier><identifier>PMID: 38345146</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Adhesion ; Adhesive strength ; Calcium ; Calcium oxalate ; Calculi ; Cell membranes ; Crystals ; Hydrogen bonding ; Hydrogen bonds ; Lipid bilayers ; Lipid membranes ; Lipids ; Membranes ; Nephrolithiasis ; Oxalic acid ; Phospholipids ; Unit cell ; Water chemistry</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2024-02, Vol.12 (9), p.2274-2281</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c296t-b3bf164a23d58a2b6d2cce054b394067d2ac6d82c2a49c2d599b32a4f365abc13</cites><orcidid>0009-0002-0809-3750 ; 0000-0002-3548-0652</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38345146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cui, Ziyu</creatorcontrib><creatorcontrib>Chin, Che-Lun</creatorcontrib><creatorcontrib>Kurniawan, Akhtar Fikri</creatorcontrib><creatorcontrib>Huang, Ching-Chun</creatorcontrib><creatorcontrib>Huang, Ling-Ting</creatorcontrib><creatorcontrib>Chao, Ling</creatorcontrib><title>Size-selective adhesion of calcium oxalate monohydrate crystals to lipid membranes</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>The retention of calcium oxalate monohydrate (COM) crystals on cell membranes is pivotal in kidney stone formation. However, the mechanisms underlying COM attachment to neutral lipid membranes remain unclear. In this study, we demonstrate that COM exhibits size-selective adhesion to fluid lipid membranes composed of lipids with distinct sizes. Specifically, the (100) facet of COM induces the formation of new domains and establishes strong adhesion in the 18:1 (Δ9-Cis) PC (DOPC) membrane, while the (010) facet induces domains with strong adhesion in the 16:0-14:0 PC membrane. This selectivity is linked to the compatibility of the area per lipid in DOPC with the unit cell area of the (100) facet and the area per lipid in 16:0-14:0 PC with the (010) facet. Our Raman spectroscopic analyses reveal that the lipid acyl chains within these induced domains exhibit a higher degree of ordering compared to the typical fluid state of the membrane. This ordered structural alignment, combined with the lateral size-matching effect, suggests the potential formation of molecular arrays within the lipid bilayer that are in harmony with the lattice dimension of COM. To elucidate the strong adhesion between calcium oxalate and the phospholipid head group in the absence of a direct molecular structural correspondence, we propose that crystal water associated with COM can form hydrogen bonds with the phospholipid head group. Using structure visualization software, we demonstrate the feasibility of such hydrogen bonding networks. The formation of this network could serve to stabilize and enhance the attachment of COM to the lipid membrane. This mediation by water molecules offers a plausible explanation for the pronounced affinity at the interface.
Our findings demonstrate that calcium oxalate monohydrate crystals can size-selectively influence the organization of fluid phospholipid membranes and facilitate the size-selective adhesion, potentially
via
water-mediated hydrogen bonding.</description><subject>Adhesion</subject><subject>Adhesive strength</subject><subject>Calcium</subject><subject>Calcium oxalate</subject><subject>Calculi</subject><subject>Cell membranes</subject><subject>Crystals</subject><subject>Hydrogen bonding</subject><subject>Hydrogen bonds</subject><subject>Lipid bilayers</subject><subject>Lipid membranes</subject><subject>Lipids</subject><subject>Membranes</subject><subject>Nephrolithiasis</subject><subject>Oxalic acid</subject><subject>Phospholipids</subject><subject>Unit cell</subject><subject>Water chemistry</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpdkUtLAzEUhYMoVmo37pWAGxFG85hJJ0utTywIWsHdkNfQ1JlJTWbE-utNba3g3dwD9-NwOBeAA4zOMKL8XNNWIpLm9G0L7BGUoWSY4Xx7o9FrDwxCmKE4OWY5TXdBj8aV4ZTtgadn-2WSYCqjWvthoNBTE6xroCuhEpWyXQ3dp6hEa2DtGjddaL_Uyi9CK6oAWwcrO7ca1qaWXjQm7IOdMl7MYL374OXmejK6S8aPt_eji3GiCGdtIqksMUsFoTrLBZFME6UMylJJeYrYUBOhmM6JIiLliuiMc0mjLinLhFSY9sHJynfu3XtnQlvUNihTVTGE60JBOGEoFsBZRI__oTPX-SamixQllOWMLanTFaW8C8Gbsph7Wwu_KDAqlmUXV3Ry-VP2Q4SP1padrI3eoL_VRuBwBfigNte_b9FvLUyDoA</recordid><startdate>20240228</startdate><enddate>20240228</enddate><creator>Cui, Ziyu</creator><creator>Chin, Che-Lun</creator><creator>Kurniawan, Akhtar Fikri</creator><creator>Huang, Ching-Chun</creator><creator>Huang, Ling-Ting</creator><creator>Chao, Ling</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0002-0809-3750</orcidid><orcidid>https://orcid.org/0000-0002-3548-0652</orcidid></search><sort><creationdate>20240228</creationdate><title>Size-selective adhesion of calcium oxalate monohydrate crystals to lipid membranes</title><author>Cui, Ziyu ; Chin, Che-Lun ; Kurniawan, Akhtar Fikri ; Huang, Ching-Chun ; Huang, Ling-Ting ; Chao, Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-b3bf164a23d58a2b6d2cce054b394067d2ac6d82c2a49c2d599b32a4f365abc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adhesion</topic><topic>Adhesive strength</topic><topic>Calcium</topic><topic>Calcium oxalate</topic><topic>Calculi</topic><topic>Cell membranes</topic><topic>Crystals</topic><topic>Hydrogen bonding</topic><topic>Hydrogen bonds</topic><topic>Lipid bilayers</topic><topic>Lipid membranes</topic><topic>Lipids</topic><topic>Membranes</topic><topic>Nephrolithiasis</topic><topic>Oxalic acid</topic><topic>Phospholipids</topic><topic>Unit cell</topic><topic>Water chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cui, Ziyu</creatorcontrib><creatorcontrib>Chin, Che-Lun</creatorcontrib><creatorcontrib>Kurniawan, Akhtar Fikri</creatorcontrib><creatorcontrib>Huang, Ching-Chun</creatorcontrib><creatorcontrib>Huang, Ling-Ting</creatorcontrib><creatorcontrib>Chao, Ling</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cui, Ziyu</au><au>Chin, Che-Lun</au><au>Kurniawan, Akhtar Fikri</au><au>Huang, Ching-Chun</au><au>Huang, Ling-Ting</au><au>Chao, Ling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Size-selective adhesion of calcium oxalate monohydrate crystals to lipid membranes</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2024-02-28</date><risdate>2024</risdate><volume>12</volume><issue>9</issue><spage>2274</spage><epage>2281</epage><pages>2274-2281</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>The retention of calcium oxalate monohydrate (COM) crystals on cell membranes is pivotal in kidney stone formation. However, the mechanisms underlying COM attachment to neutral lipid membranes remain unclear. In this study, we demonstrate that COM exhibits size-selective adhesion to fluid lipid membranes composed of lipids with distinct sizes. Specifically, the (100) facet of COM induces the formation of new domains and establishes strong adhesion in the 18:1 (Δ9-Cis) PC (DOPC) membrane, while the (010) facet induces domains with strong adhesion in the 16:0-14:0 PC membrane. This selectivity is linked to the compatibility of the area per lipid in DOPC with the unit cell area of the (100) facet and the area per lipid in 16:0-14:0 PC with the (010) facet. Our Raman spectroscopic analyses reveal that the lipid acyl chains within these induced domains exhibit a higher degree of ordering compared to the typical fluid state of the membrane. This ordered structural alignment, combined with the lateral size-matching effect, suggests the potential formation of molecular arrays within the lipid bilayer that are in harmony with the lattice dimension of COM. To elucidate the strong adhesion between calcium oxalate and the phospholipid head group in the absence of a direct molecular structural correspondence, we propose that crystal water associated with COM can form hydrogen bonds with the phospholipid head group. Using structure visualization software, we demonstrate the feasibility of such hydrogen bonding networks. The formation of this network could serve to stabilize and enhance the attachment of COM to the lipid membrane. This mediation by water molecules offers a plausible explanation for the pronounced affinity at the interface.
Our findings demonstrate that calcium oxalate monohydrate crystals can size-selectively influence the organization of fluid phospholipid membranes and facilitate the size-selective adhesion, potentially
via
water-mediated hydrogen bonding.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38345146</pmid><doi>10.1039/d3tb02483k</doi><tpages>8</tpages><orcidid>https://orcid.org/0009-0002-0809-3750</orcidid><orcidid>https://orcid.org/0000-0002-3548-0652</orcidid></addata></record> |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Adhesion Adhesive strength Calcium Calcium oxalate Calculi Cell membranes Crystals Hydrogen bonding Hydrogen bonds Lipid bilayers Lipid membranes Lipids Membranes Nephrolithiasis Oxalic acid Phospholipids Unit cell Water chemistry |
| title | Size-selective adhesion of calcium oxalate monohydrate crystals to lipid membranes |
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