Novel quinoline/thiazinan-4-one hybrids; design, synthesis, and molecular docking studies as potential anti-bacterial candidates against MRSA

In an attempt to develop effective and safe antibacterial agents, we synthesized novel thiazinanones by combining the quinolone scaffold and the 1,3-thiazinan-4-one group by reaction between ((4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)methylene)hydrazinecarbothioamides and 2,3-diphenylcycloprop-2-eno...

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Veröffentlicht in:	RSC advances 2023-05, Vol.13 (21), p.14631-1464
Hauptverfasser:	Mohamed, Asmaa H, Mostafa, Sara M, Aly, Ashraf A, Hassan, Alaa A, Osman, Esraa M, Nayl, AbdElAziz A, Brown, Alan B, Abdelhafez, Elshimaa M. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial materials Chemical analysis Chemical synthesis Chemistry Ethanol Molecular docking Molecular interactions NMR spectroscopy Quinoline Refluxing Spectrum analysis
Online-Zugang:	Volltext
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