Copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent

A simple and effective method for the copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides with ethyl bromodifluoroacetate as the bifunctional reagent was developed. The combination of cupric catalyst and alkaline additive results in a C5-bromination reactio...

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Veröffentlicht in:	RSC advances 2023-02, Vol.13 (1), p.6993-6999
Hauptverfasser:	Shao, Changdong, Xu, Tianyi, Chen, Chen, Yang, Qionglin, Tang, Chao, Chen, Ping, Lu, Mingzhu, Hu, Zhengsong, Hu, Huayou, Zhang, Tingting
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Aminoquinolines Bromination Catalysts Chemistry Copper Reagents Substrates
Online-Zugang:	Volltext
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