An enhanced stereoselective synthesis of α,β-unsaturated esters through the Horner-Wadsworth-Emmons reaction in deep eutectic solvents

A new scalable synthesis of ( E )-α,β-unsaturated esters has been developed using protic, non-toxic, and biodegradable deep eutectic solvents through the Horner-Wadsworth-Emmons reaction between triethyl phosphonates and (hetero)aromatic carbonyl compounds, encompassing electron-withdrawing and elec...

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Veröffentlicht in:Organic & biomolecular chemistry 2024-02, Vol.22 (9), p.1885-1891
Hauptverfasser: Paparella, Andrea Nicola, Stallone, Margherita, Pulpito, Mara, Perna, Filippo Maria, Capriati, Vito, Vitale, Paola
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Sprache:eng
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