Alkylation of N H-sulfoximines under Mitsunobu-type conditions

Alkylation of N H-sulfoximines under Mitsunobu-type conditions

Previously described approaches for the alkylation of H-sulfoximines typically rely either on transition metal catalysis, or the use of traditional alkylation reagents and strong bases. Herein, we report a straightforward alkylation of diverse H-sulfoximines under simple Mitsunobu-type conditions, d...

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Veröffentlicht in:Organic & biomolecular chemistry 2023-06, Vol.21 (25), p.5181-5184
Hauptverfasser: Dodd, Cayden J, Schultz, Daniel C, Li, Jinming, Lindsley, Craig W, Bender, Aaron M
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container_issue 25
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container_title Organic & biomolecular chemistry
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creator Dodd, Cayden J
Schultz, Daniel C
Li, Jinming
Lindsley, Craig W
Bender, Aaron M
description Previously described approaches for the alkylation of H-sulfoximines typically rely either on transition metal catalysis, or the use of traditional alkylation reagents and strong bases. Herein, we report a straightforward alkylation of diverse H-sulfoximines under simple Mitsunobu-type conditions, despite the unusually high p of the H center.
doi_str_mv 10.1039/d3ob00810j
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title Alkylation of N H-sulfoximines under Mitsunobu-type conditions
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