New mixed-ligand Zn()-based MOF as a nanocarrier platform for improved antibacterial activity of clinically approved drug levofloxacin
The advancement of metal-organic frameworks (MOFs) operating as drug delivery systems is of extensive interest as their controlled drug release and specific delivery are very propitious. Herein, we report a new metal-organic framework (Zn-nMOF) formulated from a mixed ligand system comprising 5-hydr...
Gespeichert in:
| Veröffentlicht in: | New journal of chemistry 2023-04, Vol.47 (15), p.7416-7424 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7424 |
|---|---|
| container_issue | 15 |
| container_start_page | 7416 |
| container_title | New journal of chemistry |
| container_volume | 47 |
| creator | Bhat, Zia Ul Haq Hanif, Summaiya Rafi, Zeeshan Alam, Mohammad Jane Ahmad, Musheer Shakir, M |
| description | The advancement of metal-organic frameworks (MOFs) operating as drug delivery systems is of extensive interest as their controlled drug release and specific delivery are very propitious. Herein, we report a new metal-organic framework (Zn-nMOF) formulated from a mixed ligand system comprising 5-hydroxyisophthalate ions (
L
1
) and 5,5′-dimethyl-2,2′-bipyridine (
L
2
) with zinc ions serving as metal centers. The crystal structure of the synthesized MOF was determined by single-crystal X-ray analysis and further supported by FTIR, PXRD, TEM, SEM, EDX, and UV/visible spectroscopy. The loading of a clinically approved broad-spectrum drug levofloxacin onto this zinc-based MOF was achieved by activating the pendent hydroxyl groups of the organic linker (5-hydroxyisophthalic acid) onto the surface of the MOF using the activator 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The confirmation of successful conjugation of levofloxacin onto the MOF and formation of Levo@Zn-nMOF was well supported by FTIR, UV/visible, SEM, and EDX techniques. The levofloxacin-conjugated Zn-nMOF (Levo@Zn-nMOF) showed increased antibacterial efficacy compared to pure levofloxacin against Gram-positive and Gram-negative bacteria, specifically
S. aureus
(MIC-64.4 μg mL
−1
),
B. subtilis
(MIC-94.97 μg mL
−1
),
E. coli
(MIC-26.0 μg mL
−1
), and
P. aeruginosa
(MIC-67.48 μg mL
−1
). The efficiency of conjugated levofloxacin showed improvement by 1.65 times, 1.71 times, 1.56 times, and 1.03 times in
S. aureus
,
B. subtilis
,
E. coli
, and
P. aeruginosa
, respectively. This work shows that a significant increase in antibacterial efficacy can be achieved for certain antibiotics by conjugating them to the MOF surface through a covalent bond linkage.
The advancement of metal-organic frameworks (MOFs) operating as drug delivery systems is of extensive interest as their controlled drug release and specific delivery are very propitious. |
| doi_str_mv | 10.1039/d3nj00114h |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_D3NJ00114H</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2798968078</sourcerecordid><originalsourceid>FETCH-LOGICAL-c281t-473b020da6be68072b29f01964e03021511d3478ec6740afd6b687e59f1707723</originalsourceid><addsrcrecordid>eNpF0b1OwzAQAOAIgUQpLOxIllgAKWDHqR2PqFAKKu0CC0t0ceziynGKnZb2BXhu0h_BcnfDp7vTXRSdE3xLMBV3JXUzjAlJPw-iDqFMxCJh5LCtSZrGuJey4-gkhK3hjHSin7H6RpVZqTK2ZgquRB_u6jouIKgSvU4GCAIC5MDVErw3yqO5hUbXvkJtQKaa-3rZUnCNKUA2yhuwqC3M0jRrVGskrXFGgrVrBPO9Lv1iiqxa1trWK5DGnUZHGmxQZ_vcjd4Hj2_9YTyaPD3370exTDLSxCmnBU5wCaxQLMM8KRKhMREsVZjihPQIKWnKMyUZTzHokhUs46onNOGY84R2o8td33aRr4UKTT6rF961I_OEi0xsmmatutkp6esQvNL53JsK_DonON_cOX-g45ftnYctvthhH-Sf-_8D_QWJ2Xps</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2798968078</pqid></control><display><type>article</type><title>New mixed-ligand Zn()-based MOF as a nanocarrier platform for improved antibacterial activity of clinically approved drug levofloxacin</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Bhat, Zia Ul Haq ; Hanif, Summaiya ; Rafi, Zeeshan ; Alam, Mohammad Jane ; Ahmad, Musheer ; Shakir, M</creator><creatorcontrib>Bhat, Zia Ul Haq ; Hanif, Summaiya ; Rafi, Zeeshan ; Alam, Mohammad Jane ; Ahmad, Musheer ; Shakir, M</creatorcontrib><description>The advancement of metal-organic frameworks (MOFs) operating as drug delivery systems is of extensive interest as their controlled drug release and specific delivery are very propitious. Herein, we report a new metal-organic framework (Zn-nMOF) formulated from a mixed ligand system comprising 5-hydroxyisophthalate ions (
L
1
) and 5,5′-dimethyl-2,2′-bipyridine (
L
2
) with zinc ions serving as metal centers. The crystal structure of the synthesized MOF was determined by single-crystal X-ray analysis and further supported by FTIR, PXRD, TEM, SEM, EDX, and UV/visible spectroscopy. The loading of a clinically approved broad-spectrum drug levofloxacin onto this zinc-based MOF was achieved by activating the pendent hydroxyl groups of the organic linker (5-hydroxyisophthalic acid) onto the surface of the MOF using the activator 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The confirmation of successful conjugation of levofloxacin onto the MOF and formation of Levo@Zn-nMOF was well supported by FTIR, UV/visible, SEM, and EDX techniques. The levofloxacin-conjugated Zn-nMOF (Levo@Zn-nMOF) showed increased antibacterial efficacy compared to pure levofloxacin against Gram-positive and Gram-negative bacteria, specifically
S. aureus
(MIC-64.4 μg mL
−1
),
B. subtilis
(MIC-94.97 μg mL
−1
),
E. coli
(MIC-26.0 μg mL
−1
), and
P. aeruginosa
(MIC-67.48 μg mL
−1
). The efficiency of conjugated levofloxacin showed improvement by 1.65 times, 1.71 times, 1.56 times, and 1.03 times in
S. aureus
,
B. subtilis
,
E. coli
, and
P. aeruginosa
, respectively. This work shows that a significant increase in antibacterial efficacy can be achieved for certain antibiotics by conjugating them to the MOF surface through a covalent bond linkage.
The advancement of metal-organic frameworks (MOFs) operating as drug delivery systems is of extensive interest as their controlled drug release and specific delivery are very propitious.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/d3nj00114h</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Antibiotics ; Conjugation ; Covalent bonds ; Crystal structure ; Drug delivery systems ; E coli ; Effectiveness ; Hydroxyl groups ; Ligands ; Metal-organic frameworks ; Single crystals ; X ray analysis ; Zinc</subject><ispartof>New journal of chemistry, 2023-04, Vol.47 (15), p.7416-7424</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c281t-473b020da6be68072b29f01964e03021511d3478ec6740afd6b687e59f1707723</citedby><cites>FETCH-LOGICAL-c281t-473b020da6be68072b29f01964e03021511d3478ec6740afd6b687e59f1707723</cites><orcidid>0000-0002-5238-411X ; 0000-0002-7446-0232</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Bhat, Zia Ul Haq</creatorcontrib><creatorcontrib>Hanif, Summaiya</creatorcontrib><creatorcontrib>Rafi, Zeeshan</creatorcontrib><creatorcontrib>Alam, Mohammad Jane</creatorcontrib><creatorcontrib>Ahmad, Musheer</creatorcontrib><creatorcontrib>Shakir, M</creatorcontrib><title>New mixed-ligand Zn()-based MOF as a nanocarrier platform for improved antibacterial activity of clinically approved drug levofloxacin</title><title>New journal of chemistry</title><description>The advancement of metal-organic frameworks (MOFs) operating as drug delivery systems is of extensive interest as their controlled drug release and specific delivery are very propitious. Herein, we report a new metal-organic framework (Zn-nMOF) formulated from a mixed ligand system comprising 5-hydroxyisophthalate ions (
L
1
) and 5,5′-dimethyl-2,2′-bipyridine (
L
2
) with zinc ions serving as metal centers. The crystal structure of the synthesized MOF was determined by single-crystal X-ray analysis and further supported by FTIR, PXRD, TEM, SEM, EDX, and UV/visible spectroscopy. The loading of a clinically approved broad-spectrum drug levofloxacin onto this zinc-based MOF was achieved by activating the pendent hydroxyl groups of the organic linker (5-hydroxyisophthalic acid) onto the surface of the MOF using the activator 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The confirmation of successful conjugation of levofloxacin onto the MOF and formation of Levo@Zn-nMOF was well supported by FTIR, UV/visible, SEM, and EDX techniques. The levofloxacin-conjugated Zn-nMOF (Levo@Zn-nMOF) showed increased antibacterial efficacy compared to pure levofloxacin against Gram-positive and Gram-negative bacteria, specifically
S. aureus
(MIC-64.4 μg mL
−1
),
B. subtilis
(MIC-94.97 μg mL
−1
),
E. coli
(MIC-26.0 μg mL
−1
), and
P. aeruginosa
(MIC-67.48 μg mL
−1
). The efficiency of conjugated levofloxacin showed improvement by 1.65 times, 1.71 times, 1.56 times, and 1.03 times in
S. aureus
,
B. subtilis
,
E. coli
, and
P. aeruginosa
, respectively. This work shows that a significant increase in antibacterial efficacy can be achieved for certain antibiotics by conjugating them to the MOF surface through a covalent bond linkage.
The advancement of metal-organic frameworks (MOFs) operating as drug delivery systems is of extensive interest as their controlled drug release and specific delivery are very propitious.</description><subject>Antibiotics</subject><subject>Conjugation</subject><subject>Covalent bonds</subject><subject>Crystal structure</subject><subject>Drug delivery systems</subject><subject>E coli</subject><subject>Effectiveness</subject><subject>Hydroxyl groups</subject><subject>Ligands</subject><subject>Metal-organic frameworks</subject><subject>Single crystals</subject><subject>X ray analysis</subject><subject>Zinc</subject><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpF0b1OwzAQAOAIgUQpLOxIllgAKWDHqR2PqFAKKu0CC0t0ceziynGKnZb2BXhu0h_BcnfDp7vTXRSdE3xLMBV3JXUzjAlJPw-iDqFMxCJh5LCtSZrGuJey4-gkhK3hjHSin7H6RpVZqTK2ZgquRB_u6jouIKgSvU4GCAIC5MDVErw3yqO5hUbXvkJtQKaa-3rZUnCNKUA2yhuwqC3M0jRrVGskrXFGgrVrBPO9Lv1iiqxa1trWK5DGnUZHGmxQZ_vcjd4Hj2_9YTyaPD3370exTDLSxCmnBU5wCaxQLMM8KRKhMREsVZjihPQIKWnKMyUZTzHokhUs46onNOGY84R2o8td33aRr4UKTT6rF961I_OEi0xsmmatutkp6esQvNL53JsK_DonON_cOX-g45ftnYctvthhH-Sf-_8D_QWJ2Xps</recordid><startdate>20230411</startdate><enddate>20230411</enddate><creator>Bhat, Zia Ul Haq</creator><creator>Hanif, Summaiya</creator><creator>Rafi, Zeeshan</creator><creator>Alam, Mohammad Jane</creator><creator>Ahmad, Musheer</creator><creator>Shakir, M</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>H9R</scope><scope>JG9</scope><scope>KA0</scope><orcidid>https://orcid.org/0000-0002-5238-411X</orcidid><orcidid>https://orcid.org/0000-0002-7446-0232</orcidid></search><sort><creationdate>20230411</creationdate><title>New mixed-ligand Zn()-based MOF as a nanocarrier platform for improved antibacterial activity of clinically approved drug levofloxacin</title><author>Bhat, Zia Ul Haq ; Hanif, Summaiya ; Rafi, Zeeshan ; Alam, Mohammad Jane ; Ahmad, Musheer ; Shakir, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-473b020da6be68072b29f01964e03021511d3478ec6740afd6b687e59f1707723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antibiotics</topic><topic>Conjugation</topic><topic>Covalent bonds</topic><topic>Crystal structure</topic><topic>Drug delivery systems</topic><topic>E coli</topic><topic>Effectiveness</topic><topic>Hydroxyl groups</topic><topic>Ligands</topic><topic>Metal-organic frameworks</topic><topic>Single crystals</topic><topic>X ray analysis</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhat, Zia Ul Haq</creatorcontrib><creatorcontrib>Hanif, Summaiya</creatorcontrib><creatorcontrib>Rafi, Zeeshan</creatorcontrib><creatorcontrib>Alam, Mohammad Jane</creatorcontrib><creatorcontrib>Ahmad, Musheer</creatorcontrib><creatorcontrib>Shakir, M</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Illustrata: Natural Sciences</collection><collection>Materials Research Database</collection><collection>ProQuest Illustrata: Technology Collection</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhat, Zia Ul Haq</au><au>Hanif, Summaiya</au><au>Rafi, Zeeshan</au><au>Alam, Mohammad Jane</au><au>Ahmad, Musheer</au><au>Shakir, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New mixed-ligand Zn()-based MOF as a nanocarrier platform for improved antibacterial activity of clinically approved drug levofloxacin</atitle><jtitle>New journal of chemistry</jtitle><date>2023-04-11</date><risdate>2023</risdate><volume>47</volume><issue>15</issue><spage>7416</spage><epage>7424</epage><pages>7416-7424</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>The advancement of metal-organic frameworks (MOFs) operating as drug delivery systems is of extensive interest as their controlled drug release and specific delivery are very propitious. Herein, we report a new metal-organic framework (Zn-nMOF) formulated from a mixed ligand system comprising 5-hydroxyisophthalate ions (
L
1
) and 5,5′-dimethyl-2,2′-bipyridine (
L
2
) with zinc ions serving as metal centers. The crystal structure of the synthesized MOF was determined by single-crystal X-ray analysis and further supported by FTIR, PXRD, TEM, SEM, EDX, and UV/visible spectroscopy. The loading of a clinically approved broad-spectrum drug levofloxacin onto this zinc-based MOF was achieved by activating the pendent hydroxyl groups of the organic linker (5-hydroxyisophthalic acid) onto the surface of the MOF using the activator 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The confirmation of successful conjugation of levofloxacin onto the MOF and formation of Levo@Zn-nMOF was well supported by FTIR, UV/visible, SEM, and EDX techniques. The levofloxacin-conjugated Zn-nMOF (Levo@Zn-nMOF) showed increased antibacterial efficacy compared to pure levofloxacin against Gram-positive and Gram-negative bacteria, specifically
S. aureus
(MIC-64.4 μg mL
−1
),
B. subtilis
(MIC-94.97 μg mL
−1
),
E. coli
(MIC-26.0 μg mL
−1
), and
P. aeruginosa
(MIC-67.48 μg mL
−1
). The efficiency of conjugated levofloxacin showed improvement by 1.65 times, 1.71 times, 1.56 times, and 1.03 times in
S. aureus
,
B. subtilis
,
E. coli
, and
P. aeruginosa
, respectively. This work shows that a significant increase in antibacterial efficacy can be achieved for certain antibiotics by conjugating them to the MOF surface through a covalent bond linkage.
The advancement of metal-organic frameworks (MOFs) operating as drug delivery systems is of extensive interest as their controlled drug release and specific delivery are very propitious.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d3nj00114h</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5238-411X</orcidid><orcidid>https://orcid.org/0000-0002-7446-0232</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1144-0546 |
| ispartof | New journal of chemistry, 2023-04, Vol.47 (15), p.7416-7424 |
| issn | 1144-0546 1369-9261 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D3NJ00114H |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Antibiotics Conjugation Covalent bonds Crystal structure Drug delivery systems E coli Effectiveness Hydroxyl groups Ligands Metal-organic frameworks Single crystals X ray analysis Zinc |
| title | New mixed-ligand Zn()-based MOF as a nanocarrier platform for improved antibacterial activity of clinically approved drug levofloxacin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T08%3A56%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20mixed-ligand%20Zn()-based%20MOF%20as%20a%20nanocarrier%20platform%20for%20improved%20antibacterial%20activity%20of%20clinically%20approved%20drug%20levofloxacin&rft.jtitle=New%20journal%20of%20chemistry&rft.au=Bhat,%20Zia%20Ul%20Haq&rft.date=2023-04-11&rft.volume=47&rft.issue=15&rft.spage=7416&rft.epage=7424&rft.pages=7416-7424&rft.issn=1144-0546&rft.eissn=1369-9261&rft_id=info:doi/10.1039/d3nj00114h&rft_dat=%3Cproquest_cross%3E2798968078%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2798968078&rft_id=info:pmid/&rfr_iscdi=true |