The relationship between vitamin K and T2DM: a systematic review and meta-analysis
Background : Previous studies have shown the potential role of vitamin K supplementation in the prevention and treatment of many diseases. However, the effect of vitamin K supplementation on blood glucose remains controversial. The purpose of this study was to assess the effects of vitamin K supplem...
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| Veröffentlicht in: | Food & function 2023-10, Vol.14 (19), p.8951-8963 |
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| creator | Qu, Boyang Yan, Shoumeng Ao, Yanrong Chen, Xingyang Zheng, Xiangyu Cui, Weiwei |
| description | Background
: Previous studies have shown the potential role of vitamin K supplementation in the prevention and treatment of many diseases. However, the effect of vitamin K supplementation on blood glucose remains controversial. The purpose of this study was to assess the effects of vitamin K supplementation on glycemia-related indicators, including Fasting Blood Sugar (FBS), Fasting Insulin (FINS) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). The potential association between vitamin K and type 2 diabetes mellitus (T2DM) risk was also evaluated.
Methods
: Up to April 2023, Cochrane, PubMed, Web of Science, Medline and EMBASE databases were searched to assess the effects of vitamin K on blood glucose and the risk of developing T2DM.
Results
: A
meta
-analysis of seven studies (813 participants) found vitamin K supplementation significantly reduced FBS (SMD = −0.150 mg dl
−1
, 95% CI = −0.290, −0.010 mg dl
−1
) and HOMA-IR (SMD = −0.200, 95% CI = −0.330, −0.060), but not FINS. Five studies with a total of 105 798 participants were included in the
meta
-analysis of the association between vitamin K and T2DM. The results showed that vitamin K was associated with the reduced risk of developing T2DM (HR = 0.79, 95% CI [0.71-0.88],
P
< 0.001).
Conclusion
: The
meta
-analysis demonstrated that vitamin K supplementation had a significant effect on the regulation of FBS and HOMA-IR in the population. Moreover, vitamin K was associated with the reduced risk of developing T2DM. Considering some limitations found in this study, additional data from large clinical trials are needed.
Previous studies have shown the potential role of vitamin K supplementation in the prevention and treatment of many diseases. |
| doi_str_mv | 10.1039/d3fo02943c |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_D3FO02943C</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2866377302</sourcerecordid><originalsourceid>FETCH-LOGICAL-c314t-c03b0bac3c29217a3dd67e11d02f37c7fcd2450da4045c6ca6b98441a403b4cb3</originalsourceid><addsrcrecordid>eNpd0UtLAzEQAOAgCpbai3ch4EWE1cmj2Y03aa2KlYJU8LZks1maso-a7Lb035u2PsC5JMN8GcIMQucEbggweZuzogEqOdNHqEeB00gM4eP4586lOEUD75cQgkmZyKSH3uYLg50pVWub2i_sCmem3RhT47VtVWVr_IJVneM5Hb_eYYX91remClqHV2trNvtqZVoVqVqVW2_9GTopVOnN4Pvso_fJw3z0FE1nj8-j-2mkGeFtpIFlkCnNNJWUxIrluYgNITnQgsU6LnRO-RByxYEPtdBKZDLhnIScZVxnrI-uDn1XrvnsjG_TynptylLVpul8ShMhWBwzoIFe_qPLpnPhvzsVg5RSJBDU9UFp13jvTJGunK2U26YE0t2E0zGbzPYTHgV8ccDO61_3twH2BUc4doA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2870999680</pqid></control><display><type>article</type><title>The relationship between vitamin K and T2DM: a systematic review and meta-analysis</title><source>Royal Society Of Chemistry Journals 2008-</source><creator>Qu, Boyang ; Yan, Shoumeng ; Ao, Yanrong ; Chen, Xingyang ; Zheng, Xiangyu ; Cui, Weiwei</creator><creatorcontrib>Qu, Boyang ; Yan, Shoumeng ; Ao, Yanrong ; Chen, Xingyang ; Zheng, Xiangyu ; Cui, Weiwei</creatorcontrib><description>Background
: Previous studies have shown the potential role of vitamin K supplementation in the prevention and treatment of many diseases. However, the effect of vitamin K supplementation on blood glucose remains controversial. The purpose of this study was to assess the effects of vitamin K supplementation on glycemia-related indicators, including Fasting Blood Sugar (FBS), Fasting Insulin (FINS) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). The potential association between vitamin K and type 2 diabetes mellitus (T2DM) risk was also evaluated.
Methods
: Up to April 2023, Cochrane, PubMed, Web of Science, Medline and EMBASE databases were searched to assess the effects of vitamin K on blood glucose and the risk of developing T2DM.
Results
: A
meta
-analysis of seven studies (813 participants) found vitamin K supplementation significantly reduced FBS (SMD = −0.150 mg dl
−1
, 95% CI = −0.290, −0.010 mg dl
−1
) and HOMA-IR (SMD = −0.200, 95% CI = −0.330, −0.060), but not FINS. Five studies with a total of 105 798 participants were included in the
meta
-analysis of the association between vitamin K and T2DM. The results showed that vitamin K was associated with the reduced risk of developing T2DM (HR = 0.79, 95% CI [0.71-0.88],
P
< 0.001).
Conclusion
: The
meta
-analysis demonstrated that vitamin K supplementation had a significant effect on the regulation of FBS and HOMA-IR in the population. Moreover, vitamin K was associated with the reduced risk of developing T2DM. Considering some limitations found in this study, additional data from large clinical trials are needed.
Previous studies have shown the potential role of vitamin K supplementation in the prevention and treatment of many diseases.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d3fo02943c</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Blood ; Blood glucose ; Clinical trials ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Dietary supplements ; Fasting ; Fins ; Glucose ; Health risks ; Homeostasis ; Insulin ; Insulin resistance ; Laboratory testing ; Meta-analysis ; Phylloquinone ; Risk management ; Vitamin K</subject><ispartof>Food & function, 2023-10, Vol.14 (19), p.8951-8963</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-c03b0bac3c29217a3dd67e11d02f37c7fcd2450da4045c6ca6b98441a403b4cb3</citedby><cites>FETCH-LOGICAL-c314t-c03b0bac3c29217a3dd67e11d02f37c7fcd2450da4045c6ca6b98441a403b4cb3</cites><orcidid>0000-0002-0028-8564</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Qu, Boyang</creatorcontrib><creatorcontrib>Yan, Shoumeng</creatorcontrib><creatorcontrib>Ao, Yanrong</creatorcontrib><creatorcontrib>Chen, Xingyang</creatorcontrib><creatorcontrib>Zheng, Xiangyu</creatorcontrib><creatorcontrib>Cui, Weiwei</creatorcontrib><title>The relationship between vitamin K and T2DM: a systematic review and meta-analysis</title><title>Food & function</title><description>Background
: Previous studies have shown the potential role of vitamin K supplementation in the prevention and treatment of many diseases. However, the effect of vitamin K supplementation on blood glucose remains controversial. The purpose of this study was to assess the effects of vitamin K supplementation on glycemia-related indicators, including Fasting Blood Sugar (FBS), Fasting Insulin (FINS) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). The potential association between vitamin K and type 2 diabetes mellitus (T2DM) risk was also evaluated.
Methods
: Up to April 2023, Cochrane, PubMed, Web of Science, Medline and EMBASE databases were searched to assess the effects of vitamin K on blood glucose and the risk of developing T2DM.
Results
: A
meta
-analysis of seven studies (813 participants) found vitamin K supplementation significantly reduced FBS (SMD = −0.150 mg dl
−1
, 95% CI = −0.290, −0.010 mg dl
−1
) and HOMA-IR (SMD = −0.200, 95% CI = −0.330, −0.060), but not FINS. Five studies with a total of 105 798 participants were included in the
meta
-analysis of the association between vitamin K and T2DM. The results showed that vitamin K was associated with the reduced risk of developing T2DM (HR = 0.79, 95% CI [0.71-0.88],
P
< 0.001).
Conclusion
: The
meta
-analysis demonstrated that vitamin K supplementation had a significant effect on the regulation of FBS and HOMA-IR in the population. Moreover, vitamin K was associated with the reduced risk of developing T2DM. Considering some limitations found in this study, additional data from large clinical trials are needed.
Previous studies have shown the potential role of vitamin K supplementation in the prevention and treatment of many diseases.</description><subject>Blood</subject><subject>Blood glucose</subject><subject>Clinical trials</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Dietary supplements</subject><subject>Fasting</subject><subject>Fins</subject><subject>Glucose</subject><subject>Health risks</subject><subject>Homeostasis</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Laboratory testing</subject><subject>Meta-analysis</subject><subject>Phylloquinone</subject><subject>Risk management</subject><subject>Vitamin K</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpd0UtLAzEQAOAgCpbai3ch4EWE1cmj2Y03aa2KlYJU8LZks1maso-a7Lb035u2PsC5JMN8GcIMQucEbggweZuzogEqOdNHqEeB00gM4eP4586lOEUD75cQgkmZyKSH3uYLg50pVWub2i_sCmem3RhT47VtVWVr_IJVneM5Hb_eYYX91remClqHV2trNvtqZVoVqVqVW2_9GTopVOnN4Pvso_fJw3z0FE1nj8-j-2mkGeFtpIFlkCnNNJWUxIrluYgNITnQgsU6LnRO-RByxYEPtdBKZDLhnIScZVxnrI-uDn1XrvnsjG_TynptylLVpul8ShMhWBwzoIFe_qPLpnPhvzsVg5RSJBDU9UFp13jvTJGunK2U26YE0t2E0zGbzPYTHgV8ccDO61_3twH2BUc4doA</recordid><startdate>20231002</startdate><enddate>20231002</enddate><creator>Qu, Boyang</creator><creator>Yan, Shoumeng</creator><creator>Ao, Yanrong</creator><creator>Chen, Xingyang</creator><creator>Zheng, Xiangyu</creator><creator>Cui, Weiwei</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0028-8564</orcidid></search><sort><creationdate>20231002</creationdate><title>The relationship between vitamin K and T2DM: a systematic review and meta-analysis</title><author>Qu, Boyang ; Yan, Shoumeng ; Ao, Yanrong ; Chen, Xingyang ; Zheng, Xiangyu ; Cui, Weiwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-c03b0bac3c29217a3dd67e11d02f37c7fcd2450da4045c6ca6b98441a403b4cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Blood</topic><topic>Blood glucose</topic><topic>Clinical trials</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Dietary supplements</topic><topic>Fasting</topic><topic>Fins</topic><topic>Glucose</topic><topic>Health risks</topic><topic>Homeostasis</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Laboratory testing</topic><topic>Meta-analysis</topic><topic>Phylloquinone</topic><topic>Risk management</topic><topic>Vitamin K</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qu, Boyang</creatorcontrib><creatorcontrib>Yan, Shoumeng</creatorcontrib><creatorcontrib>Ao, Yanrong</creatorcontrib><creatorcontrib>Chen, Xingyang</creatorcontrib><creatorcontrib>Zheng, Xiangyu</creatorcontrib><creatorcontrib>Cui, Weiwei</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qu, Boyang</au><au>Yan, Shoumeng</au><au>Ao, Yanrong</au><au>Chen, Xingyang</au><au>Zheng, Xiangyu</au><au>Cui, Weiwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between vitamin K and T2DM: a systematic review and meta-analysis</atitle><jtitle>Food & function</jtitle><date>2023-10-02</date><risdate>2023</risdate><volume>14</volume><issue>19</issue><spage>8951</spage><epage>8963</epage><pages>8951-8963</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Background
: Previous studies have shown the potential role of vitamin K supplementation in the prevention and treatment of many diseases. However, the effect of vitamin K supplementation on blood glucose remains controversial. The purpose of this study was to assess the effects of vitamin K supplementation on glycemia-related indicators, including Fasting Blood Sugar (FBS), Fasting Insulin (FINS) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). The potential association between vitamin K and type 2 diabetes mellitus (T2DM) risk was also evaluated.
Methods
: Up to April 2023, Cochrane, PubMed, Web of Science, Medline and EMBASE databases were searched to assess the effects of vitamin K on blood glucose and the risk of developing T2DM.
Results
: A
meta
-analysis of seven studies (813 participants) found vitamin K supplementation significantly reduced FBS (SMD = −0.150 mg dl
−1
, 95% CI = −0.290, −0.010 mg dl
−1
) and HOMA-IR (SMD = −0.200, 95% CI = −0.330, −0.060), but not FINS. Five studies with a total of 105 798 participants were included in the
meta
-analysis of the association between vitamin K and T2DM. The results showed that vitamin K was associated with the reduced risk of developing T2DM (HR = 0.79, 95% CI [0.71-0.88],
P
< 0.001).
Conclusion
: The
meta
-analysis demonstrated that vitamin K supplementation had a significant effect on the regulation of FBS and HOMA-IR in the population. Moreover, vitamin K was associated with the reduced risk of developing T2DM. Considering some limitations found in this study, additional data from large clinical trials are needed.
Previous studies have shown the potential role of vitamin K supplementation in the prevention and treatment of many diseases.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d3fo02943c</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-0028-8564</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Food & function, 2023-10, Vol.14 (19), p.8951-8963 |
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| language | eng |
| recordid | cdi_crossref_primary_10_1039_D3FO02943C |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Blood Blood glucose Clinical trials Diabetes mellitus Diabetes mellitus (non-insulin dependent) Dietary supplements Fasting Fins Glucose Health risks Homeostasis Insulin Insulin resistance Laboratory testing Meta-analysis Phylloquinone Risk management Vitamin K |
| title | The relationship between vitamin K and T2DM: a systematic review and meta-analysis |
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