Utilising the intrinsic fluorescence of pomalidomide for imaging applications

Optimisation of protein degraders requires balancing multiple factors including potency, cell permeability and solubility. Here we show that the fluorescence of pomalidomide can be used in high-throughput screening assays to rapidly assess cellular penetration of degrader candidates. In addition, th...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2023-12, Vol.59 (98), p.14532-14535
Hauptverfasser:	Brownsey, Duncan K, Gafuik, Christopher J, Kim, Dae-Sun, O'Sullivan, Leonie, Gorobets, Evgueni, Krukowski, Samuel, Turk, Madison, Jenne, Craig N, Mahoney, Douglas J, Derksen, Darren J
Format:	Artikel
Sprache:	eng
Schlagworte:	Conjugates Fluorescence Microscopy, Fluorescence Thalidomide - pharmacology
Online-Zugang:	Volltext
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