Short peptide-based cross-β amyloids exploit dual residues for phosphoesterase like activity

Herein, we report that short peptides are capable of exploiting their anti-parallel registry to access cross-β stacks to expose more than one catalytic residue, exhibiting the traits of advanced binding pockets of enzymes. Binding pockets decorated with more than one catalytic residue facilitate sub...

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Veröffentlicht in:	Chemical science (Cambridge) 2022-08, Vol.13 (32), p.9225-9231
Hauptverfasser:	Mahato, Chiranjit, Menon, Sneha, Singh, Abhishek, Afrose, Syed Pavel, Mondal, Jagannath, Das, Dibyendu
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biopolymers Chemistry Congeners Histidine Imidazole Mutation Nucleic acids Peptides Residues Substrates
Online-Zugang:	Volltext
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