Coatings of hydroxyapatite-bioactive glass microparticles for adhesion to biological tissues
Adsorption of particles across interfaces has been proposed as a way to create adhesion between hydrogels and biological tissues. Here, we explore how this particle bridging approach can be applied to attach a soft polymer substrate to biological tissues, using bioresorbable and nanostructured hydro...
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| Veröffentlicht in: | RSC advances 2022-07, Vol.12 (33), p.2179-2191 |
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| creator | Palierse, Estelle Roquart, Maïlie Norvez, Sophie Corté, Laurent |
| description | Adsorption of particles across interfaces has been proposed as a way to create adhesion between hydrogels and biological tissues. Here, we explore how this particle bridging approach can be applied to attach a soft polymer substrate to biological tissues, using bioresorbable and nanostructured hydroxyapatite-bioactive glass microparticles. For this, microparticles of aggregated flower-like hydroxyapatite and bioactive glass (HA-BG) were synthesized
via
a bioinspired route. A deposition technique using suspension spreading was developed to tune the coverage of HA-BG coatings at the surface of weakly cross-linked poly(beta-thioester) films. By varying the concentration of the deposited suspensions, we produced coatings having surface coverages ranging from 4% to 100% and coating densities ranging from 0.02 to 1.0 mg cm
−2
. The progressive dissolution of these coatings within 21 days in phosphate-buffered saline was followed by SEM.
Ex vivo
peeling experiments on pig liver capsules demonstrated that HA-BG coatings produce an up-to-two-fold increase in adhesion energy (9.8 ± 1.5 J m
−2
) as compared to the uncoated film (4.6 ± 0.8 J m
−2
). Adhesion energy was found to increase with increasing coating density until a maximum at 0.2 mg cm
−2
, well below full surface coverage, and then it decreased for larger coating densities. Using microscopy observations during and after peeling, we show that this maximum in adhesion corresponds to the appearance of particle stacks, which are easily separated and transferred onto the tissue. Such bioresorbable HA-BG coatings give the possibility of combining particle bridging with the storage and release of active compounds, therefore offering opportunities to design functional bioadhesive surfaces.
Coatings of hydroxyapatite-bioactive glass microparticles are proposed as a way to create adhesion between hydrogels and biological tissues using adsorption of the microparticles across the interface. |
| doi_str_mv | 10.1039/d2ra02781j |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_D2RA02781J</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2697676233</sourcerecordid><originalsourceid>FETCH-LOGICAL-c458t-46d87c8844d890f678c1292f057cb4f1f08c41e0bfb3ab75faf071c740b60cb53</originalsourceid><addsrcrecordid>eNpdkk1rGzEQhkVoaYLrS-4Jgl6awLb62JW0l4JxvhoMhdLeAkKrlWyZ9cqRZBP_-8hx6jrRRWLm0TuadwTAKUbfMKL195YEhQgXeH4ETggqWUEQqz8cnI_BMMY5yotVmDD8CRzTqsa1oOwEPIy9Sq6fRugtnG3a4J82aplDyRSN80ontzZw2qkY4cLp4JcqJKc7E6H1Aap2ZqLzPUweZrzzU6dVB5OLcWXiZ_DRqi6a4es-AH9vrv-M74rJr9uf49Gk0GUlUlGyVnAtRFm2okaWcaExqYlFFddNabFFQpfYoMY2VDW8ssoijjUvUcOQbio6AD92ustVszCtNn0KqpPL4BYqbKRXTr7N9G4mp34ta5prkK3AxU5g9u7a3Wgit7HsNEcC8zXO7NfXYsE_5iaTXLioTdep3vhVlITVnHFGKM3ol3fo3K9Cn63YUoKSCiOWqcsdld2NMRi7fwFGcjtjeUV-j15mfJ_h88NW9-i_iWbgbAeEqPfZ_5-EPgMX0Kxx</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2698325106</pqid></control><display><type>article</type><title>Coatings of hydroxyapatite-bioactive glass microparticles for adhesion to biological tissues</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Palierse, Estelle ; Roquart, Maïlie ; Norvez, Sophie ; Corté, Laurent</creator><creatorcontrib>Palierse, Estelle ; Roquart, Maïlie ; Norvez, Sophie ; Corté, Laurent</creatorcontrib><description>Adsorption of particles across interfaces has been proposed as a way to create adhesion between hydrogels and biological tissues. Here, we explore how this particle bridging approach can be applied to attach a soft polymer substrate to biological tissues, using bioresorbable and nanostructured hydroxyapatite-bioactive glass microparticles. For this, microparticles of aggregated flower-like hydroxyapatite and bioactive glass (HA-BG) were synthesized
via
a bioinspired route. A deposition technique using suspension spreading was developed to tune the coverage of HA-BG coatings at the surface of weakly cross-linked poly(beta-thioester) films. By varying the concentration of the deposited suspensions, we produced coatings having surface coverages ranging from 4% to 100% and coating densities ranging from 0.02 to 1.0 mg cm
−2
. The progressive dissolution of these coatings within 21 days in phosphate-buffered saline was followed by SEM.
Ex vivo
peeling experiments on pig liver capsules demonstrated that HA-BG coatings produce an up-to-two-fold increase in adhesion energy (9.8 ± 1.5 J m
−2
) as compared to the uncoated film (4.6 ± 0.8 J m
−2
). Adhesion energy was found to increase with increasing coating density until a maximum at 0.2 mg cm
−2
, well below full surface coverage, and then it decreased for larger coating densities. Using microscopy observations during and after peeling, we show that this maximum in adhesion corresponds to the appearance of particle stacks, which are easily separated and transferred onto the tissue. Such bioresorbable HA-BG coatings give the possibility of combining particle bridging with the storage and release of active compounds, therefore offering opportunities to design functional bioadhesive surfaces.
Coatings of hydroxyapatite-bioactive glass microparticles are proposed as a way to create adhesion between hydrogels and biological tissues using adsorption of the microparticles across the interface.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d2ra02781j</identifier><identifier>PMID: 35919836</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Adhesion ; Biocompatibility ; Bioglass ; Biological activity ; Biomedical materials ; Chemical Sciences ; Chemistry ; Coatings ; Engineering Sciences ; Hydrogels ; Hydroxyapatite ; Microparticles ; Peeling ; Physics ; Substrates ; Tissues</subject><ispartof>RSC advances, 2022-07, Vol.12 (33), p.2179-2191</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2022</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>This journal is © The Royal Society of Chemistry 2022 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-46d87c8844d890f678c1292f057cb4f1f08c41e0bfb3ab75faf071c740b60cb53</citedby><cites>FETCH-LOGICAL-c458t-46d87c8844d890f678c1292f057cb4f1f08c41e0bfb3ab75faf071c740b60cb53</cites><orcidid>0000-0002-9732-3265 ; 0000-0003-2643-5347 ; 0000-0002-2478-0393</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305725/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9305725/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35919836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03970817$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Palierse, Estelle</creatorcontrib><creatorcontrib>Roquart, Maïlie</creatorcontrib><creatorcontrib>Norvez, Sophie</creatorcontrib><creatorcontrib>Corté, Laurent</creatorcontrib><title>Coatings of hydroxyapatite-bioactive glass microparticles for adhesion to biological tissues</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Adsorption of particles across interfaces has been proposed as a way to create adhesion between hydrogels and biological tissues. Here, we explore how this particle bridging approach can be applied to attach a soft polymer substrate to biological tissues, using bioresorbable and nanostructured hydroxyapatite-bioactive glass microparticles. For this, microparticles of aggregated flower-like hydroxyapatite and bioactive glass (HA-BG) were synthesized
via
a bioinspired route. A deposition technique using suspension spreading was developed to tune the coverage of HA-BG coatings at the surface of weakly cross-linked poly(beta-thioester) films. By varying the concentration of the deposited suspensions, we produced coatings having surface coverages ranging from 4% to 100% and coating densities ranging from 0.02 to 1.0 mg cm
−2
. The progressive dissolution of these coatings within 21 days in phosphate-buffered saline was followed by SEM.
Ex vivo
peeling experiments on pig liver capsules demonstrated that HA-BG coatings produce an up-to-two-fold increase in adhesion energy (9.8 ± 1.5 J m
−2
) as compared to the uncoated film (4.6 ± 0.8 J m
−2
). Adhesion energy was found to increase with increasing coating density until a maximum at 0.2 mg cm
−2
, well below full surface coverage, and then it decreased for larger coating densities. Using microscopy observations during and after peeling, we show that this maximum in adhesion corresponds to the appearance of particle stacks, which are easily separated and transferred onto the tissue. Such bioresorbable HA-BG coatings give the possibility of combining particle bridging with the storage and release of active compounds, therefore offering opportunities to design functional bioadhesive surfaces.
Coatings of hydroxyapatite-bioactive glass microparticles are proposed as a way to create adhesion between hydrogels and biological tissues using adsorption of the microparticles across the interface.</description><subject>Adhesion</subject><subject>Biocompatibility</subject><subject>Bioglass</subject><subject>Biological activity</subject><subject>Biomedical materials</subject><subject>Chemical Sciences</subject><subject>Chemistry</subject><subject>Coatings</subject><subject>Engineering Sciences</subject><subject>Hydrogels</subject><subject>Hydroxyapatite</subject><subject>Microparticles</subject><subject>Peeling</subject><subject>Physics</subject><subject>Substrates</subject><subject>Tissues</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkk1rGzEQhkVoaYLrS-4Jgl6awLb62JW0l4JxvhoMhdLeAkKrlWyZ9cqRZBP_-8hx6jrRRWLm0TuadwTAKUbfMKL195YEhQgXeH4ETggqWUEQqz8cnI_BMMY5yotVmDD8CRzTqsa1oOwEPIy9Sq6fRugtnG3a4J82aplDyRSN80ontzZw2qkY4cLp4JcqJKc7E6H1Aap2ZqLzPUweZrzzU6dVB5OLcWXiZ_DRqi6a4es-AH9vrv-M74rJr9uf49Gk0GUlUlGyVnAtRFm2okaWcaExqYlFFddNabFFQpfYoMY2VDW8ssoijjUvUcOQbio6AD92ustVszCtNn0KqpPL4BYqbKRXTr7N9G4mp34ta5prkK3AxU5g9u7a3Wgit7HsNEcC8zXO7NfXYsE_5iaTXLioTdep3vhVlITVnHFGKM3ol3fo3K9Cn63YUoKSCiOWqcsdld2NMRi7fwFGcjtjeUV-j15mfJ_h88NW9-i_iWbgbAeEqPfZ_5-EPgMX0Kxx</recordid><startdate>20220721</startdate><enddate>20220721</enddate><creator>Palierse, Estelle</creator><creator>Roquart, Maïlie</creator><creator>Norvez, Sophie</creator><creator>Corté, Laurent</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9732-3265</orcidid><orcidid>https://orcid.org/0000-0003-2643-5347</orcidid><orcidid>https://orcid.org/0000-0002-2478-0393</orcidid></search><sort><creationdate>20220721</creationdate><title>Coatings of hydroxyapatite-bioactive glass microparticles for adhesion to biological tissues</title><author>Palierse, Estelle ; Roquart, Maïlie ; Norvez, Sophie ; Corté, Laurent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-46d87c8844d890f678c1292f057cb4f1f08c41e0bfb3ab75faf071c740b60cb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adhesion</topic><topic>Biocompatibility</topic><topic>Bioglass</topic><topic>Biological activity</topic><topic>Biomedical materials</topic><topic>Chemical Sciences</topic><topic>Chemistry</topic><topic>Coatings</topic><topic>Engineering Sciences</topic><topic>Hydrogels</topic><topic>Hydroxyapatite</topic><topic>Microparticles</topic><topic>Peeling</topic><topic>Physics</topic><topic>Substrates</topic><topic>Tissues</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palierse, Estelle</creatorcontrib><creatorcontrib>Roquart, Maïlie</creatorcontrib><creatorcontrib>Norvez, Sophie</creatorcontrib><creatorcontrib>Corté, Laurent</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palierse, Estelle</au><au>Roquart, Maïlie</au><au>Norvez, Sophie</au><au>Corté, Laurent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coatings of hydroxyapatite-bioactive glass microparticles for adhesion to biological tissues</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2022-07-21</date><risdate>2022</risdate><volume>12</volume><issue>33</issue><spage>2179</spage><epage>2191</epage><pages>2179-2191</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Adsorption of particles across interfaces has been proposed as a way to create adhesion between hydrogels and biological tissues. Here, we explore how this particle bridging approach can be applied to attach a soft polymer substrate to biological tissues, using bioresorbable and nanostructured hydroxyapatite-bioactive glass microparticles. For this, microparticles of aggregated flower-like hydroxyapatite and bioactive glass (HA-BG) were synthesized
via
a bioinspired route. A deposition technique using suspension spreading was developed to tune the coverage of HA-BG coatings at the surface of weakly cross-linked poly(beta-thioester) films. By varying the concentration of the deposited suspensions, we produced coatings having surface coverages ranging from 4% to 100% and coating densities ranging from 0.02 to 1.0 mg cm
−2
. The progressive dissolution of these coatings within 21 days in phosphate-buffered saline was followed by SEM.
Ex vivo
peeling experiments on pig liver capsules demonstrated that HA-BG coatings produce an up-to-two-fold increase in adhesion energy (9.8 ± 1.5 J m
−2
) as compared to the uncoated film (4.6 ± 0.8 J m
−2
). Adhesion energy was found to increase with increasing coating density until a maximum at 0.2 mg cm
−2
, well below full surface coverage, and then it decreased for larger coating densities. Using microscopy observations during and after peeling, we show that this maximum in adhesion corresponds to the appearance of particle stacks, which are easily separated and transferred onto the tissue. Such bioresorbable HA-BG coatings give the possibility of combining particle bridging with the storage and release of active compounds, therefore offering opportunities to design functional bioadhesive surfaces.
Coatings of hydroxyapatite-bioactive glass microparticles are proposed as a way to create adhesion between hydrogels and biological tissues using adsorption of the microparticles across the interface.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35919836</pmid><doi>10.1039/d2ra02781j</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-9732-3265</orcidid><orcidid>https://orcid.org/0000-0003-2643-5347</orcidid><orcidid>https://orcid.org/0000-0002-2478-0393</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adhesion Biocompatibility Bioglass Biological activity Biomedical materials Chemical Sciences Chemistry Coatings Engineering Sciences Hydrogels Hydroxyapatite Microparticles Peeling Physics Substrates Tissues |
| title | Coatings of hydroxyapatite-bioactive glass microparticles for adhesion to biological tissues |
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