Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on related heterocycle-fused naphthoquinones for cancer therapy

Persistently activated signal transducer and activator of transcription 3 (STAT3) plays an important role in the development of multiple cancers, and therefore it is a potential therapeutic target for cancer treatment. Herein, we report the rational design, synthesis, and biological evaluation of no...

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Veröffentlicht in:	New journal of chemistry 2022-12, Vol.47 (1), p.156-166
Hauptverfasser:	Chen, Yuanguang, Xu, Huashen, Chen, Lu, Zhang, Maoying, Yang, Dexiao, Tong, Minghui, Shi, Xuan, Liu, Zhongbo, Chen, Guoliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Bioavailability Cancer Design analysis Inhibitors Magnetohydrodynamic stability Molecular docking Synthesis
Online-Zugang:	Volltext
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