Design, synthesis and biological evaluation of 4-phenoxy-pyridine/pyrimidine derivatives as dual VEGFR-2/c-Met inhibitors

A class of 4-phenoxy-pyridine/pyrimidine derivatives ( 23a-23p and 24a-24h ) were designed, synthesized and evaluated as potent dual VEGFR-2/c-Met inhibitors. The in vitro anti-cancer cell proliferative activity of the compounds indicated that compound 23k was regarded as a promising derivative. Com...

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Veröffentlicht in:	New journal of chemistry 2022-07, Vol.46 (26), p.12651-12665
Hauptverfasser:	Yang, Feiyi, Zhang, Qian, Guo, Qiuyan, Pan, Qingshan, Wen, Chunping, Lv, Xinya, Zhu, Wufu, Zheng, Pengwu
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Apoptosis Binding Kinases Lead compounds Molecular docking Molecular dynamics Pyridines Selectivity Toxicity
Online-Zugang:	Volltext
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