Interrogation of the Pathogen Box reveals small molecule ligands against the mycobacterial trehalose transporter LpqY-SugABC

Tuberculosis, caused by Mycobacterium tuberculosis , claims ∼1.5 million lives annually. Effective chemotherapy is essential to control TB, however the emergence of drug-resistant strains of TB have seriously threatened global attempts to control and eradicate this deadly pathogen. Trehalose recycli...

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Veröffentlicht in:	MedChemComm 2022-10, Vol.13 (1), p.1225-1233
Hauptverfasser:	Radhakrishnan, Anjana, Brown, Chelsea M, Guy, Collette S, Cooper, Charlotte, Pacheco-Gomez, Raul, Stansfeld, Phillip J, Fullam, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemotherapy Diagnostic agents Drug development Drug resistance Interrogation Malaria Pathogens Transportation systems Trehalose Tuberculosis Vector-borne diseases Virulence
Online-Zugang:	Volltext
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