Photoinduced water-chromophore electron transfer causes formation of guanosine photodamage

UV-induced photolysis of aqueous guanine nucleosides produces 8-oxo-guanine and Fapy-guanine, which can induce various types of cellular malfunction. The mechanistic rationale underlying photodestructive processes of guanine nucleosides is still largely obscure. Here, we employ accurate quantum chem...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2022-04, Vol.24 (14), p.8217-8224
Hauptverfasser:	Janicki, Miko aj J, Szabla, Rafa, Šponer, Ji í, Góra, Robert W
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical reactions Chromophores Electron transfer Electrons Guanine - chemistry Guanosine - chemistry Guanosines Nucleosides Nucleosides - chemistry Photolysis Quantum chemistry Water - chemistry
Online-Zugang:	Volltext
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