Metastable intermediate during hIAPP aggregation catalyzed by membranes as detected with 2D IR spectroscopy

The aggregation of human islet amyloid polypeptide (hIAPP) into amyloid fibrils involves formation of oligomeric intermediates that are thought to be the cytotoxic species responsible for β-cell dysfunction in type 2 diabetes. hIAPP oligomers permeating or disrupting the cellular membrane may be one...

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Veröffentlicht in:	RSC chemical biology 2022-07, Vol.3 (7), p.931-94
Hauptverfasser:	Dicke, Sidney S, Maj, Micha, Fields, Caitlyn R, Zanni, Martin T
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry and Molecular Biology Biokemi och molekylärbiologi Chemistry
Online-Zugang:	Volltext
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