Identifying the grade of bladder cancer cells using microfluidic chips based on impedance
Quantification of tumor cell heterogeneity is critical for clinical diagnostic and therapeutic applications, including evaluation of the cancerous stage of tumors. In this work, we presented a novel method to effectively distinguish the grade of bladder cancer at a single-cell level in both cell lin...
Gespeichert in:
| Veröffentlicht in: | Analyst (London) 2022-04, Vol.147 (8), p.1722-1729 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1729 |
|---|---|
| container_issue | 8 |
| container_start_page | 1722 |
| container_title | Analyst (London) |
| container_volume | 147 |
| creator | Fan, Weihua Xiong, Qiao Ge, Yuqing liu, Ting Zeng, Shuxiong Zhao, Jianlong |
| description | Quantification of tumor cell heterogeneity is critical for clinical diagnostic and therapeutic applications, including evaluation of the cancerous stage of tumors. In this work, we presented a novel method to effectively distinguish the grade of bladder cancer at a single-cell level in both cell line and clinical cell samples. This was achieved by taking advantage of microdroplets and microelectrodes, which can encapsulate and then trap single cells for measuring their impedance in a label-free and non-invasive manner. These findings suggested that this impedance analysis device based on droplet microfluidics is promising in the fields of clinical and point-of-care diagnostics.
Bladder cancer diagnosis is made by microfluidic chip based-on impedance analysis. |
| doi_str_mv | 10.1039/d2an00026a |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_D2AN00026A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2648975131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c267t-147b25f5db89ed864d9224c0620a6b276803e2a84751e2f96ff0cce4b3a8b72c3</originalsourceid><addsrcrecordid>eNpd0TlPwzAYBmALgWgpLOwgSywIKeA7yViVq1IFCwxMkeOjNcpR7GTov8ehpUhMn2w_tj-_BuAco1uMaH6niWwQQkTIAzDGVLCEc5IdgnGcpAkRnI3ASQifcYgRR8dgRDlllBM8Bh9zbZrO2Y1rlrBbGbj0UhvYWlhWUmvjoZKNGoqpqgD7MLjaKd_aqnfaKahWbh1gKYPRsG2gq9dGD1tOwZGVVTBnuzoB748Pb7PnZPH6NJ9NF4kiIu0SzNKScMt1meVGZ4LpnBCmkCBIipKkIkPUEJmxlGNDbC6sRUoZVlKZlSlRdAKut-euffvVm9AVtQtDt7IxbR8KIhiLmWCKIr36Rz_b3jexu0FlebyC4qhutio-MgRvbLH2rpZ-U2BUDIEX92T68hP4NOLL3ZF9WRu9p78JR3CxBT6o_erfj9FvJauDpw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2648975131</pqid></control><display><type>article</type><title>Identifying the grade of bladder cancer cells using microfluidic chips based on impedance</title><source>MEDLINE</source><source>Royal Society of Chemistry Journals Archive (1841-2007)</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Fan, Weihua ; Xiong, Qiao ; Ge, Yuqing ; liu, Ting ; Zeng, Shuxiong ; Zhao, Jianlong</creator><creatorcontrib>Fan, Weihua ; Xiong, Qiao ; Ge, Yuqing ; liu, Ting ; Zeng, Shuxiong ; Zhao, Jianlong</creatorcontrib><description>Quantification of tumor cell heterogeneity is critical for clinical diagnostic and therapeutic applications, including evaluation of the cancerous stage of tumors. In this work, we presented a novel method to effectively distinguish the grade of bladder cancer at a single-cell level in both cell line and clinical cell samples. This was achieved by taking advantage of microdroplets and microelectrodes, which can encapsulate and then trap single cells for measuring their impedance in a label-free and non-invasive manner. These findings suggested that this impedance analysis device based on droplet microfluidics is promising in the fields of clinical and point-of-care diagnostics.
Bladder cancer diagnosis is made by microfluidic chip based-on impedance analysis.</description><identifier>ISSN: 0003-2654</identifier><identifier>EISSN: 1364-5528</identifier><identifier>DOI: 10.1039/d2an00026a</identifier><identifier>PMID: 35343521</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Bladder ; Bladder cancer ; Cancer ; Cell Line ; Electric Impedance ; Heterogeneity ; Humans ; Impedance ; Microelectrodes ; Microfluidic Analytical Techniques ; Microfluidics ; Microfluidics - methods ; Tumors ; Urinary Bladder Neoplasms - diagnosis</subject><ispartof>Analyst (London), 2022-04, Vol.147 (8), p.1722-1729</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c267t-147b25f5db89ed864d9224c0620a6b276803e2a84751e2f96ff0cce4b3a8b72c3</citedby><cites>FETCH-LOGICAL-c267t-147b25f5db89ed864d9224c0620a6b276803e2a84751e2f96ff0cce4b3a8b72c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2831,2832,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35343521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Weihua</creatorcontrib><creatorcontrib>Xiong, Qiao</creatorcontrib><creatorcontrib>Ge, Yuqing</creatorcontrib><creatorcontrib>liu, Ting</creatorcontrib><creatorcontrib>Zeng, Shuxiong</creatorcontrib><creatorcontrib>Zhao, Jianlong</creatorcontrib><title>Identifying the grade of bladder cancer cells using microfluidic chips based on impedance</title><title>Analyst (London)</title><addtitle>Analyst</addtitle><description>Quantification of tumor cell heterogeneity is critical for clinical diagnostic and therapeutic applications, including evaluation of the cancerous stage of tumors. In this work, we presented a novel method to effectively distinguish the grade of bladder cancer at a single-cell level in both cell line and clinical cell samples. This was achieved by taking advantage of microdroplets and microelectrodes, which can encapsulate and then trap single cells for measuring their impedance in a label-free and non-invasive manner. These findings suggested that this impedance analysis device based on droplet microfluidics is promising in the fields of clinical and point-of-care diagnostics.
Bladder cancer diagnosis is made by microfluidic chip based-on impedance analysis.</description><subject>Bladder</subject><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Cell Line</subject><subject>Electric Impedance</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Impedance</subject><subject>Microelectrodes</subject><subject>Microfluidic Analytical Techniques</subject><subject>Microfluidics</subject><subject>Microfluidics - methods</subject><subject>Tumors</subject><subject>Urinary Bladder Neoplasms - diagnosis</subject><issn>0003-2654</issn><issn>1364-5528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0TlPwzAYBmALgWgpLOwgSywIKeA7yViVq1IFCwxMkeOjNcpR7GTov8ehpUhMn2w_tj-_BuAco1uMaH6niWwQQkTIAzDGVLCEc5IdgnGcpAkRnI3ASQifcYgRR8dgRDlllBM8Bh9zbZrO2Y1rlrBbGbj0UhvYWlhWUmvjoZKNGoqpqgD7MLjaKd_aqnfaKahWbh1gKYPRsG2gq9dGD1tOwZGVVTBnuzoB748Pb7PnZPH6NJ9NF4kiIu0SzNKScMt1meVGZ4LpnBCmkCBIipKkIkPUEJmxlGNDbC6sRUoZVlKZlSlRdAKut-euffvVm9AVtQtDt7IxbR8KIhiLmWCKIr36Rz_b3jexu0FlebyC4qhutio-MgRvbLH2rpZ-U2BUDIEX92T68hP4NOLL3ZF9WRu9p78JR3CxBT6o_erfj9FvJauDpw</recordid><startdate>20220411</startdate><enddate>20220411</enddate><creator>Fan, Weihua</creator><creator>Xiong, Qiao</creator><creator>Ge, Yuqing</creator><creator>liu, Ting</creator><creator>Zeng, Shuxiong</creator><creator>Zhao, Jianlong</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20220411</creationdate><title>Identifying the grade of bladder cancer cells using microfluidic chips based on impedance</title><author>Fan, Weihua ; Xiong, Qiao ; Ge, Yuqing ; liu, Ting ; Zeng, Shuxiong ; Zhao, Jianlong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-147b25f5db89ed864d9224c0620a6b276803e2a84751e2f96ff0cce4b3a8b72c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bladder</topic><topic>Bladder cancer</topic><topic>Cancer</topic><topic>Cell Line</topic><topic>Electric Impedance</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Impedance</topic><topic>Microelectrodes</topic><topic>Microfluidic Analytical Techniques</topic><topic>Microfluidics</topic><topic>Microfluidics - methods</topic><topic>Tumors</topic><topic>Urinary Bladder Neoplasms - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fan, Weihua</creatorcontrib><creatorcontrib>Xiong, Qiao</creatorcontrib><creatorcontrib>Ge, Yuqing</creatorcontrib><creatorcontrib>liu, Ting</creatorcontrib><creatorcontrib>Zeng, Shuxiong</creatorcontrib><creatorcontrib>Zhao, Jianlong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Analyst (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fan, Weihua</au><au>Xiong, Qiao</au><au>Ge, Yuqing</au><au>liu, Ting</au><au>Zeng, Shuxiong</au><au>Zhao, Jianlong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identifying the grade of bladder cancer cells using microfluidic chips based on impedance</atitle><jtitle>Analyst (London)</jtitle><addtitle>Analyst</addtitle><date>2022-04-11</date><risdate>2022</risdate><volume>147</volume><issue>8</issue><spage>1722</spage><epage>1729</epage><pages>1722-1729</pages><issn>0003-2654</issn><eissn>1364-5528</eissn><abstract>Quantification of tumor cell heterogeneity is critical for clinical diagnostic and therapeutic applications, including evaluation of the cancerous stage of tumors. In this work, we presented a novel method to effectively distinguish the grade of bladder cancer at a single-cell level in both cell line and clinical cell samples. This was achieved by taking advantage of microdroplets and microelectrodes, which can encapsulate and then trap single cells for measuring their impedance in a label-free and non-invasive manner. These findings suggested that this impedance analysis device based on droplet microfluidics is promising in the fields of clinical and point-of-care diagnostics.
Bladder cancer diagnosis is made by microfluidic chip based-on impedance analysis.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35343521</pmid><doi>10.1039/d2an00026a</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-2654 |
| ispartof | Analyst (London), 2022-04, Vol.147 (8), p.1722-1729 |
| issn | 0003-2654 1364-5528 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D2AN00026A |
| source | MEDLINE; Royal Society of Chemistry Journals Archive (1841-2007); Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Bladder Bladder cancer Cancer Cell Line Electric Impedance Heterogeneity Humans Impedance Microelectrodes Microfluidic Analytical Techniques Microfluidics Microfluidics - methods Tumors Urinary Bladder Neoplasms - diagnosis |
| title | Identifying the grade of bladder cancer cells using microfluidic chips based on impedance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T08%3A23%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identifying%20the%20grade%20of%20bladder%20cancer%20cells%20using%20microfluidic%20chips%20based%20on%20impedance&rft.jtitle=Analyst%20(London)&rft.au=Fan,%20Weihua&rft.date=2022-04-11&rft.volume=147&rft.issue=8&rft.spage=1722&rft.epage=1729&rft.pages=1722-1729&rft.issn=0003-2654&rft.eissn=1364-5528&rft_id=info:doi/10.1039/d2an00026a&rft_dat=%3Cproquest_cross%3E2648975131%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2648975131&rft_id=info:pmid/35343521&rfr_iscdi=true |