Grafting of Gd-DTPA onto MOF-808 to enhance MRI performance for guiding photothermal therapy
Gd( iii ) chelates are important T 1 -weighted contrast agents used in clinical magnetic resonance imaging (MRI), but their low longitudinal relaxivity ( r 1 ) results in limited imaging efficiency. In this study, we utilize a geometric confinement strategy to restrict a Gd chelate (Gd-DTPA) within...
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Jia, Mingjie Yang, Xinyu Chen, Yanan He, Meie Zhou, Weixiu Lin, Jiaomin An, Lu Yang, Shiping |
| description | Gd(
iii
) chelates are important
T
1
-weighted contrast agents used in clinical magnetic resonance imaging (MRI), but their low longitudinal relaxivity (
r
1
) results in limited imaging efficiency. In this study, we utilize a geometric confinement strategy to restrict a Gd chelate (Gd-DTPA) within the channels of a porous metal-organic framework material (MOF-808) for increasing its
r
1
relaxivity. Moreover, the Gd-DTPA-grafted MOF-808 nanoparticles were further surface modified with polyaniline (PANI) to construct an MRI-guided photothermal therapy platform. The resulting Gd-DTPA-MOF-808@PANI shows a high
r
1
relaxivity of 30.1 mM
−1
s
−1
(0.5 T), which is 5.4 times higher than that of the commercial contrast agent Magnevist.
In vivo
experiments revealed that Gd-DTPA-MOF-808@PANI has good
T
1
-weighted contrast performance and can effectively guide photothermal ablation of tumors upon 808 nm laser irradiation. This work may shed some light on the design and preparation of high relaxation rate Gd-based contrast agents for theranostic application
via
utilization of versatile MOF materials.
A MRI guided photothermal therapy agent Gd-DTPA-MOF-808@PANI was developed through grafting
T
1
-weight contrast agent Gd-DTPA molecule within the porous channel of MOF-808 and modified with polyaniline (PANI). |
| doi_str_mv | 10.1039/d1tb01596f |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_D1TB01596F</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2577733304</sourcerecordid><originalsourceid>FETCH-LOGICAL-c378t-f6a4f59e899a702070fcd1bf110f002bb19da080b13d22cbdda048b98864e0d03</originalsourceid><addsrcrecordid>eNpdkctLAzEQxoMottRevCsBLyKsTja7m-yxPloLLRWp4EFYspukD9rNmuwe-t-bPqzgXOYb5jcf4QtClwTuCdD0QZI6BxKniT5B7RBiCFhM-OlRw2cLdZ1bgi9OEk6jc9SiUcxjRuI2-hpYoetFOcNG44EMnqdvPWzK2uDxpB9w4NhLVc5FWSg8fh_iSllt7Ho3e4FnzUJuz6u5qU09V361wtsuqs0FOtNi5VT30Dvoo_8yfXoNRpPB8Kk3CgrKeB3oREQ6ThVPU8EgBAa6kCTXhIAGCPOcpFIAh5xQGYZFLv0U8TzlPIkUSKAddLv3raz5bpSrs_XCFWq1EqUyjcvCmDFGKYXIozf_0KVpbOlf5ynvlzBOQ0_d7anCGues0lllF2thNxmBbBt79kymj7vY-x6-Plg2-VrJI_obsgeu9oB1xXH792_0B0kRhHI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2586467832</pqid></control><display><type>article</type><title>Grafting of Gd-DTPA onto MOF-808 to enhance MRI performance for guiding photothermal therapy</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><creator>Jia, Mingjie ; Yang, Xinyu ; Chen, Yanan ; He, Meie ; Zhou, Weixiu ; Lin, Jiaomin ; An, Lu ; Yang, Shiping</creator><creatorcontrib>Jia, Mingjie ; Yang, Xinyu ; Chen, Yanan ; He, Meie ; Zhou, Weixiu ; Lin, Jiaomin ; An, Lu ; Yang, Shiping</creatorcontrib><description>Gd(
iii
) chelates are important
T
1
-weighted contrast agents used in clinical magnetic resonance imaging (MRI), but their low longitudinal relaxivity (
r
1
) results in limited imaging efficiency. In this study, we utilize a geometric confinement strategy to restrict a Gd chelate (Gd-DTPA) within the channels of a porous metal-organic framework material (MOF-808) for increasing its
r
1
relaxivity. Moreover, the Gd-DTPA-grafted MOF-808 nanoparticles were further surface modified with polyaniline (PANI) to construct an MRI-guided photothermal therapy platform. The resulting Gd-DTPA-MOF-808@PANI shows a high
r
1
relaxivity of 30.1 mM
−1
s
−1
(0.5 T), which is 5.4 times higher than that of the commercial contrast agent Magnevist.
In vivo
experiments revealed that Gd-DTPA-MOF-808@PANI has good
T
1
-weighted contrast performance and can effectively guide photothermal ablation of tumors upon 808 nm laser irradiation. This work may shed some light on the design and preparation of high relaxation rate Gd-based contrast agents for theranostic application
via
utilization of versatile MOF materials.
A MRI guided photothermal therapy agent Gd-DTPA-MOF-808@PANI was developed through grafting
T
1
-weight contrast agent Gd-DTPA molecule within the porous channel of MOF-808 and modified with polyaniline (PANI).</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d1tb01596f</identifier><identifier>PMID: 34585715</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Ablation ; Aniline Compounds - chemistry ; Animals ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Cells, Cultured ; Chelates ; Contrast agents ; Contrast media ; Drug Screening Assays, Antitumor ; Female ; Gadolinium ; Gadolinium DTPA - chemical synthesis ; Gadolinium DTPA - chemistry ; Gadolinium DTPA - pharmacology ; Gadopentetate dimeglumine ; Humans ; Irradiation ; Lasers ; Magnetic Resonance Imaging ; Mammary Neoplasms, Experimental - diagnostic imaging ; Mammary Neoplasms, Experimental - drug therapy ; Metal-organic frameworks ; Metal-Organic Frameworks - chemical synthesis ; Metal-Organic Frameworks - chemistry ; Metal-Organic Frameworks - pharmacology ; Mice ; Nanoparticles ; Nanoparticles - chemistry ; Particle Size ; Photothermal Therapy ; Polyanilines ; Porous materials ; Tumors</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2021-10, Vol.9 (41), p.8631-8638</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-f6a4f59e899a702070fcd1bf110f002bb19da080b13d22cbdda048b98864e0d03</citedby><cites>FETCH-LOGICAL-c378t-f6a4f59e899a702070fcd1bf110f002bb19da080b13d22cbdda048b98864e0d03</cites><orcidid>0000-0002-6696-1651 ; 0000-0001-7527-4581</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34585715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Mingjie</creatorcontrib><creatorcontrib>Yang, Xinyu</creatorcontrib><creatorcontrib>Chen, Yanan</creatorcontrib><creatorcontrib>He, Meie</creatorcontrib><creatorcontrib>Zhou, Weixiu</creatorcontrib><creatorcontrib>Lin, Jiaomin</creatorcontrib><creatorcontrib>An, Lu</creatorcontrib><creatorcontrib>Yang, Shiping</creatorcontrib><title>Grafting of Gd-DTPA onto MOF-808 to enhance MRI performance for guiding photothermal therapy</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Gd(
iii
) chelates are important
T
1
-weighted contrast agents used in clinical magnetic resonance imaging (MRI), but their low longitudinal relaxivity (
r
1
) results in limited imaging efficiency. In this study, we utilize a geometric confinement strategy to restrict a Gd chelate (Gd-DTPA) within the channels of a porous metal-organic framework material (MOF-808) for increasing its
r
1
relaxivity. Moreover, the Gd-DTPA-grafted MOF-808 nanoparticles were further surface modified with polyaniline (PANI) to construct an MRI-guided photothermal therapy platform. The resulting Gd-DTPA-MOF-808@PANI shows a high
r
1
relaxivity of 30.1 mM
−1
s
−1
(0.5 T), which is 5.4 times higher than that of the commercial contrast agent Magnevist.
In vivo
experiments revealed that Gd-DTPA-MOF-808@PANI has good
T
1
-weighted contrast performance and can effectively guide photothermal ablation of tumors upon 808 nm laser irradiation. This work may shed some light on the design and preparation of high relaxation rate Gd-based contrast agents for theranostic application
via
utilization of versatile MOF materials.
A MRI guided photothermal therapy agent Gd-DTPA-MOF-808@PANI was developed through grafting
T
1
-weight contrast agent Gd-DTPA molecule within the porous channel of MOF-808 and modified with polyaniline (PANI).</description><subject>Ablation</subject><subject>Aniline Compounds - chemistry</subject><subject>Animals</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Chelates</subject><subject>Contrast agents</subject><subject>Contrast media</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Female</subject><subject>Gadolinium</subject><subject>Gadolinium DTPA - chemical synthesis</subject><subject>Gadolinium DTPA - chemistry</subject><subject>Gadolinium DTPA - pharmacology</subject><subject>Gadopentetate dimeglumine</subject><subject>Humans</subject><subject>Irradiation</subject><subject>Lasers</subject><subject>Magnetic Resonance Imaging</subject><subject>Mammary Neoplasms, Experimental - diagnostic imaging</subject><subject>Mammary Neoplasms, Experimental - drug therapy</subject><subject>Metal-organic frameworks</subject><subject>Metal-Organic Frameworks - chemical synthesis</subject><subject>Metal-Organic Frameworks - chemistry</subject><subject>Metal-Organic Frameworks - pharmacology</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Particle Size</subject><subject>Photothermal Therapy</subject><subject>Polyanilines</subject><subject>Porous materials</subject><subject>Tumors</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctLAzEQxoMottRevCsBLyKsTja7m-yxPloLLRWp4EFYspukD9rNmuwe-t-bPqzgXOYb5jcf4QtClwTuCdD0QZI6BxKniT5B7RBiCFhM-OlRw2cLdZ1bgi9OEk6jc9SiUcxjRuI2-hpYoetFOcNG44EMnqdvPWzK2uDxpB9w4NhLVc5FWSg8fh_iSllt7Ho3e4FnzUJuz6u5qU09V361wtsuqs0FOtNi5VT30Dvoo_8yfXoNRpPB8Kk3CgrKeB3oREQ6ThVPU8EgBAa6kCTXhIAGCPOcpFIAh5xQGYZFLv0U8TzlPIkUSKAddLv3raz5bpSrs_XCFWq1EqUyjcvCmDFGKYXIozf_0KVpbOlf5ynvlzBOQ0_d7anCGues0lllF2thNxmBbBt79kymj7vY-x6-Plg2-VrJI_obsgeu9oB1xXH792_0B0kRhHI</recordid><startdate>20211027</startdate><enddate>20211027</enddate><creator>Jia, Mingjie</creator><creator>Yang, Xinyu</creator><creator>Chen, Yanan</creator><creator>He, Meie</creator><creator>Zhou, Weixiu</creator><creator>Lin, Jiaomin</creator><creator>An, Lu</creator><creator>Yang, Shiping</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6696-1651</orcidid><orcidid>https://orcid.org/0000-0001-7527-4581</orcidid></search><sort><creationdate>20211027</creationdate><title>Grafting of Gd-DTPA onto MOF-808 to enhance MRI performance for guiding photothermal therapy</title><author>Jia, Mingjie ; Yang, Xinyu ; Chen, Yanan ; He, Meie ; Zhou, Weixiu ; Lin, Jiaomin ; An, Lu ; Yang, Shiping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-f6a4f59e899a702070fcd1bf110f002bb19da080b13d22cbdda048b98864e0d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ablation</topic><topic>Aniline Compounds - chemistry</topic><topic>Animals</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>Chelates</topic><topic>Contrast agents</topic><topic>Contrast media</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Female</topic><topic>Gadolinium</topic><topic>Gadolinium DTPA - chemical synthesis</topic><topic>Gadolinium DTPA - chemistry</topic><topic>Gadolinium DTPA - pharmacology</topic><topic>Gadopentetate dimeglumine</topic><topic>Humans</topic><topic>Irradiation</topic><topic>Lasers</topic><topic>Magnetic Resonance Imaging</topic><topic>Mammary Neoplasms, Experimental - diagnostic imaging</topic><topic>Mammary Neoplasms, Experimental - drug therapy</topic><topic>Metal-organic frameworks</topic><topic>Metal-Organic Frameworks - chemical synthesis</topic><topic>Metal-Organic Frameworks - chemistry</topic><topic>Metal-Organic Frameworks - pharmacology</topic><topic>Mice</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Particle Size</topic><topic>Photothermal Therapy</topic><topic>Polyanilines</topic><topic>Porous materials</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Mingjie</creatorcontrib><creatorcontrib>Yang, Xinyu</creatorcontrib><creatorcontrib>Chen, Yanan</creatorcontrib><creatorcontrib>He, Meie</creatorcontrib><creatorcontrib>Zhou, Weixiu</creatorcontrib><creatorcontrib>Lin, Jiaomin</creatorcontrib><creatorcontrib>An, Lu</creatorcontrib><creatorcontrib>Yang, Shiping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Mingjie</au><au>Yang, Xinyu</au><au>Chen, Yanan</au><au>He, Meie</au><au>Zhou, Weixiu</au><au>Lin, Jiaomin</au><au>An, Lu</au><au>Yang, Shiping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Grafting of Gd-DTPA onto MOF-808 to enhance MRI performance for guiding photothermal therapy</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2021-10-27</date><risdate>2021</risdate><volume>9</volume><issue>41</issue><spage>8631</spage><epage>8638</epage><pages>8631-8638</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>Gd(
iii
) chelates are important
T
1
-weighted contrast agents used in clinical magnetic resonance imaging (MRI), but their low longitudinal relaxivity (
r
1
) results in limited imaging efficiency. In this study, we utilize a geometric confinement strategy to restrict a Gd chelate (Gd-DTPA) within the channels of a porous metal-organic framework material (MOF-808) for increasing its
r
1
relaxivity. Moreover, the Gd-DTPA-grafted MOF-808 nanoparticles were further surface modified with polyaniline (PANI) to construct an MRI-guided photothermal therapy platform. The resulting Gd-DTPA-MOF-808@PANI shows a high
r
1
relaxivity of 30.1 mM
−1
s
−1
(0.5 T), which is 5.4 times higher than that of the commercial contrast agent Magnevist.
In vivo
experiments revealed that Gd-DTPA-MOF-808@PANI has good
T
1
-weighted contrast performance and can effectively guide photothermal ablation of tumors upon 808 nm laser irradiation. This work may shed some light on the design and preparation of high relaxation rate Gd-based contrast agents for theranostic application
via
utilization of versatile MOF materials.
A MRI guided photothermal therapy agent Gd-DTPA-MOF-808@PANI was developed through grafting
T
1
-weight contrast agent Gd-DTPA molecule within the porous channel of MOF-808 and modified with polyaniline (PANI).</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>34585715</pmid><doi>10.1039/d1tb01596f</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6696-1651</orcidid><orcidid>https://orcid.org/0000-0001-7527-4581</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2050-750X |
| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2021-10, Vol.9 (41), p.8631-8638 |
| issn | 2050-750X 2050-7518 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D1TB01596F |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Ablation Aniline Compounds - chemistry Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Chelates Contrast agents Contrast media Drug Screening Assays, Antitumor Female Gadolinium Gadolinium DTPA - chemical synthesis Gadolinium DTPA - chemistry Gadolinium DTPA - pharmacology Gadopentetate dimeglumine Humans Irradiation Lasers Magnetic Resonance Imaging Mammary Neoplasms, Experimental - diagnostic imaging Mammary Neoplasms, Experimental - drug therapy Metal-organic frameworks Metal-Organic Frameworks - chemical synthesis Metal-Organic Frameworks - chemistry Metal-Organic Frameworks - pharmacology Mice Nanoparticles Nanoparticles - chemistry Particle Size Photothermal Therapy Polyanilines Porous materials Tumors |
| title | Grafting of Gd-DTPA onto MOF-808 to enhance MRI performance for guiding photothermal therapy |
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