Structure-antitumor activity relationships of tripodal imidazolium-amino acid based salts. Effect of the nature of the amino acid, amide substitution and anion

The antitumor activity of imidazolium salts is highly dependent upon their lipophilicity that can be tuned by the introduction of different hydrophobic substituents on the nitrogen atoms of the imidazolium ring of the molecule. Taking this into consideration, we have synthesized and characterized a...

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Veröffentlicht in:Organic & biomolecular chemistry 2021-12, Vol.19 (48), p.1575-1586
Hauptverfasser: Valls, Adriana, Altava, Belén, Aseyev, Vladimir, Carreira-Barral, Israel, Conesa, Laura, Falomir, Eva, García-Verdugo, Eduardo, Luis, Santiago Vicente, Quesada, Roberto
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Sprache:eng
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