Effects of cereal fibers on short-chain fatty acids in healthy subjects and patients: a meta-analysis of randomized clinical trials
Short-chain fatty acids (SCFAs) are involved in the regulation of a wide array of diseases. However, the effect of cereal dietary fibers on SCFA production remains unclear. We reviewed relevant clinical studies between 1950 and 2021 and aimed to evaluate the effect of cereal fiber consumption on SCF...
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| creator | Bai, Junying Li, Yan Zhang, Wenhui Fan, Mingcong Qian, Haifeng Zhang, Hui Qi, Xiguang Wang, Li |
| description | Short-chain fatty acids (SCFAs) are involved in the regulation of a wide array of diseases. However, the effect of cereal dietary fibers on SCFA production remains unclear. We reviewed relevant clinical studies between 1950 and 2021 and aimed to evaluate the effect of cereal fiber consumption on SCFA production in healthy subjects and patients. PubMed, Web of Science, and the Cochrane Library databases were used for systematically searching published relevant trials with adults and a minimum intervention duration of 2 weeks. The effect size was estimated using standardized mean difference (SMD) and 95% confidence interval (CI). Of the 555 identified studies, 14 intervention groups involving 205 participants aged between 20 and 69 years are eligible. The results of meta-analysis revealed that cereal fiber supplementation significantly increased acetate [SMD: 0.86, 95% CI (0.46, 1.25),
p
< 0.0001], propionate [SMD: 0.48, 95% CI: (0.15, 0.81),
p
= 0.004], butyrate [SMD: 0.61, 95% CI: (0.20, 1.01),
p
= 0.003], and total SCFA [SMD, 0.96, 95% CI: (0.54, 1.39),
p
< 0.00001] concentrations. Subgroup analysis suggested that a long intervention duration (>4 weeks) significantly promoted acetate and propionate production, whereas a short intervention duration (≤4 weeks) significantly facilitated butyrate production. Cereal fiber supplementation had a more significant impact on overweight and obese subjects with body mass index (BMI) >29 kg m
−2
than on individuals with BMI ≤29 kg m
−2
. Furthermore, we found that cereal fibers and wheat/rye arabinoxylan oligosaccharides, rather than wheat bran fibers, barley fibers, and barley β-glucan, could significantly elevate the SCFA concentration. Overall, our meta-analysis demonstrated that cereal fiber supplementation is helpful in increasing the SCFA concentration, which provided strong proof for the beneficial role of cereal fibers.
Cereal fiber supplementation significantly affected fecal SCFA concentrations in randomized clinical studies. A more significant impact appeared in overweight and obese subjects with BMI >29 kg m
−2
than in individuals with BMI ≤29 kg m
−2
. |
| doi_str_mv | 10.1039/d1fo00858g |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_D1FO00858G</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2559390352</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-f2e681f47b093bd51057ab008c3d7c29f7a144388018b23aaf6c91a3a0b102c23</originalsourceid><addsrcrecordid>eNpdkUtLAzEUhYMoVqob90rAjQijeU1n4k5qq4LgRsHdcCeT2JR51CSzqFv_uOlLwbs5N8l3T7gchE4puaaEy5uKmo6QPM0_9tARI4Ilo5S87-96IUcDdOL9nMTiUuYyP0QDLmjKOBdH6HtijFbB485gpZ2GGhtbahcvWuxnnQuJmoFtsYEQlhiUrTyOx1kkw2yJfV_O1_PQVngBweo2-FsMuNEBEmihXnq7dneR6Br7pSusattaFb8KzkLtj9GBiaJPtjpEb9PJ6_gxeX55eBrfPSdKEB4Sw_Qop0ZkJZG8rFJK0gzKuLviVaaYNBlQIXieE5qXjAOYkZIUOJCSEqYYH6LLje_CdZ-99qForFe6rqHVXe8LlgqeRVOxQi_-ofOud3GbFZVKLglPV9TVhlKu895pUyycbcAtC0qKVTrFPZ2-rNN5iPD51rIvG139orssInC2AZxXv69_8fIfgG2UDg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2559390352</pqid></control><display><type>article</type><title>Effects of cereal fibers on short-chain fatty acids in healthy subjects and patients: a meta-analysis of randomized clinical trials</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><creator>Bai, Junying ; Li, Yan ; Zhang, Wenhui ; Fan, Mingcong ; Qian, Haifeng ; Zhang, Hui ; Qi, Xiguang ; Wang, Li</creator><creatorcontrib>Bai, Junying ; Li, Yan ; Zhang, Wenhui ; Fan, Mingcong ; Qian, Haifeng ; Zhang, Hui ; Qi, Xiguang ; Wang, Li</creatorcontrib><description>Short-chain fatty acids (SCFAs) are involved in the regulation of a wide array of diseases. However, the effect of cereal dietary fibers on SCFA production remains unclear. We reviewed relevant clinical studies between 1950 and 2021 and aimed to evaluate the effect of cereal fiber consumption on SCFA production in healthy subjects and patients. PubMed, Web of Science, and the Cochrane Library databases were used for systematically searching published relevant trials with adults and a minimum intervention duration of 2 weeks. The effect size was estimated using standardized mean difference (SMD) and 95% confidence interval (CI). Of the 555 identified studies, 14 intervention groups involving 205 participants aged between 20 and 69 years are eligible. The results of meta-analysis revealed that cereal fiber supplementation significantly increased acetate [SMD: 0.86, 95% CI (0.46, 1.25),
p
< 0.0001], propionate [SMD: 0.48, 95% CI: (0.15, 0.81),
p
= 0.004], butyrate [SMD: 0.61, 95% CI: (0.20, 1.01),
p
= 0.003], and total SCFA [SMD, 0.96, 95% CI: (0.54, 1.39),
p
< 0.00001] concentrations. Subgroup analysis suggested that a long intervention duration (>4 weeks) significantly promoted acetate and propionate production, whereas a short intervention duration (≤4 weeks) significantly facilitated butyrate production. Cereal fiber supplementation had a more significant impact on overweight and obese subjects with body mass index (BMI) >29 kg m
−2
than on individuals with BMI ≤29 kg m
−2
. Furthermore, we found that cereal fibers and wheat/rye arabinoxylan oligosaccharides, rather than wheat bran fibers, barley fibers, and barley β-glucan, could significantly elevate the SCFA concentration. Overall, our meta-analysis demonstrated that cereal fiber supplementation is helpful in increasing the SCFA concentration, which provided strong proof for the beneficial role of cereal fibers.
Cereal fiber supplementation significantly affected fecal SCFA concentrations in randomized clinical studies. A more significant impact appeared in overweight and obese subjects with BMI >29 kg m
−2
than in individuals with BMI ≤29 kg m
−2
.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d1fo00858g</identifier><identifier>PMID: 34152334</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Acetic acid ; Adult ; Aged ; Barley ; Body mass ; Body Mass Index ; Body size ; Body weight ; Body Weight - physiology ; Clinical trials ; Confidence intervals ; Diet ; Dietary fiber ; Dietary supplements ; Edible Grain ; Fatty acids ; Fatty Acids, Volatile - blood ; Female ; Fibers ; Glucan ; Humans ; Indexing ; Male ; Meta-analysis ; Middle Aged ; Oligosaccharides ; Overweight ; Patients ; Propionic acid ; Randomized Controlled Trials as Topic ; Rye ; Subgroups ; Wheat ; Wheat bran ; Young Adult ; β-Glucan</subject><ispartof>Food & function, 2021-08, Vol.12 (15), p.74-753</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-f2e681f47b093bd51057ab008c3d7c29f7a144388018b23aaf6c91a3a0b102c23</citedby><cites>FETCH-LOGICAL-c403t-f2e681f47b093bd51057ab008c3d7c29f7a144388018b23aaf6c91a3a0b102c23</cites><orcidid>0000-0002-4401-4207 ; 0000-0002-9402-1093 ; 0000-0003-0415-8748</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34152334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bai, Junying</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Zhang, Wenhui</creatorcontrib><creatorcontrib>Fan, Mingcong</creatorcontrib><creatorcontrib>Qian, Haifeng</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Qi, Xiguang</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><title>Effects of cereal fibers on short-chain fatty acids in healthy subjects and patients: a meta-analysis of randomized clinical trials</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Short-chain fatty acids (SCFAs) are involved in the regulation of a wide array of diseases. However, the effect of cereal dietary fibers on SCFA production remains unclear. We reviewed relevant clinical studies between 1950 and 2021 and aimed to evaluate the effect of cereal fiber consumption on SCFA production in healthy subjects and patients. PubMed, Web of Science, and the Cochrane Library databases were used for systematically searching published relevant trials with adults and a minimum intervention duration of 2 weeks. The effect size was estimated using standardized mean difference (SMD) and 95% confidence interval (CI). Of the 555 identified studies, 14 intervention groups involving 205 participants aged between 20 and 69 years are eligible. The results of meta-analysis revealed that cereal fiber supplementation significantly increased acetate [SMD: 0.86, 95% CI (0.46, 1.25),
p
< 0.0001], propionate [SMD: 0.48, 95% CI: (0.15, 0.81),
p
= 0.004], butyrate [SMD: 0.61, 95% CI: (0.20, 1.01),
p
= 0.003], and total SCFA [SMD, 0.96, 95% CI: (0.54, 1.39),
p
< 0.00001] concentrations. Subgroup analysis suggested that a long intervention duration (>4 weeks) significantly promoted acetate and propionate production, whereas a short intervention duration (≤4 weeks) significantly facilitated butyrate production. Cereal fiber supplementation had a more significant impact on overweight and obese subjects with body mass index (BMI) >29 kg m
−2
than on individuals with BMI ≤29 kg m
−2
. Furthermore, we found that cereal fibers and wheat/rye arabinoxylan oligosaccharides, rather than wheat bran fibers, barley fibers, and barley β-glucan, could significantly elevate the SCFA concentration. Overall, our meta-analysis demonstrated that cereal fiber supplementation is helpful in increasing the SCFA concentration, which provided strong proof for the beneficial role of cereal fibers.
Cereal fiber supplementation significantly affected fecal SCFA concentrations in randomized clinical studies. A more significant impact appeared in overweight and obese subjects with BMI >29 kg m
−2
than in individuals with BMI ≤29 kg m
−2
.</description><subject>Acetic acid</subject><subject>Adult</subject><subject>Aged</subject><subject>Barley</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Body Weight - physiology</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Diet</subject><subject>Dietary fiber</subject><subject>Dietary supplements</subject><subject>Edible Grain</subject><subject>Fatty acids</subject><subject>Fatty Acids, Volatile - blood</subject><subject>Female</subject><subject>Fibers</subject><subject>Glucan</subject><subject>Humans</subject><subject>Indexing</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Oligosaccharides</subject><subject>Overweight</subject><subject>Patients</subject><subject>Propionic acid</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Rye</subject><subject>Subgroups</subject><subject>Wheat</subject><subject>Wheat bran</subject><subject>Young Adult</subject><subject>β-Glucan</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtLAzEUhYMoVqob90rAjQijeU1n4k5qq4LgRsHdcCeT2JR51CSzqFv_uOlLwbs5N8l3T7gchE4puaaEy5uKmo6QPM0_9tARI4Ilo5S87-96IUcDdOL9nMTiUuYyP0QDLmjKOBdH6HtijFbB485gpZ2GGhtbahcvWuxnnQuJmoFtsYEQlhiUrTyOx1kkw2yJfV_O1_PQVngBweo2-FsMuNEBEmihXnq7dneR6Br7pSusattaFb8KzkLtj9GBiaJPtjpEb9PJ6_gxeX55eBrfPSdKEB4Sw_Qop0ZkJZG8rFJK0gzKuLviVaaYNBlQIXieE5qXjAOYkZIUOJCSEqYYH6LLje_CdZ-99qForFe6rqHVXe8LlgqeRVOxQi_-ofOud3GbFZVKLglPV9TVhlKu895pUyycbcAtC0qKVTrFPZ2-rNN5iPD51rIvG139orssInC2AZxXv69_8fIfgG2UDg</recordid><startdate>20210802</startdate><enddate>20210802</enddate><creator>Bai, Junying</creator><creator>Li, Yan</creator><creator>Zhang, Wenhui</creator><creator>Fan, Mingcong</creator><creator>Qian, Haifeng</creator><creator>Zhang, Hui</creator><creator>Qi, Xiguang</creator><creator>Wang, Li</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4401-4207</orcidid><orcidid>https://orcid.org/0000-0002-9402-1093</orcidid><orcidid>https://orcid.org/0000-0003-0415-8748</orcidid></search><sort><creationdate>20210802</creationdate><title>Effects of cereal fibers on short-chain fatty acids in healthy subjects and patients: a meta-analysis of randomized clinical trials</title><author>Bai, Junying ; Li, Yan ; Zhang, Wenhui ; Fan, Mingcong ; Qian, Haifeng ; Zhang, Hui ; Qi, Xiguang ; Wang, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-f2e681f47b093bd51057ab008c3d7c29f7a144388018b23aaf6c91a3a0b102c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acetic acid</topic><topic>Adult</topic><topic>Aged</topic><topic>Barley</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Body Weight - physiology</topic><topic>Clinical trials</topic><topic>Confidence intervals</topic><topic>Diet</topic><topic>Dietary fiber</topic><topic>Dietary supplements</topic><topic>Edible Grain</topic><topic>Fatty acids</topic><topic>Fatty Acids, Volatile - blood</topic><topic>Female</topic><topic>Fibers</topic><topic>Glucan</topic><topic>Humans</topic><topic>Indexing</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Oligosaccharides</topic><topic>Overweight</topic><topic>Patients</topic><topic>Propionic acid</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Rye</topic><topic>Subgroups</topic><topic>Wheat</topic><topic>Wheat bran</topic><topic>Young Adult</topic><topic>β-Glucan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bai, Junying</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Zhang, Wenhui</creatorcontrib><creatorcontrib>Fan, Mingcong</creatorcontrib><creatorcontrib>Qian, Haifeng</creatorcontrib><creatorcontrib>Zhang, Hui</creatorcontrib><creatorcontrib>Qi, Xiguang</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bai, Junying</au><au>Li, Yan</au><au>Zhang, Wenhui</au><au>Fan, Mingcong</au><au>Qian, Haifeng</au><au>Zhang, Hui</au><au>Qi, Xiguang</au><au>Wang, Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of cereal fibers on short-chain fatty acids in healthy subjects and patients: a meta-analysis of randomized clinical trials</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2021-08-02</date><risdate>2021</risdate><volume>12</volume><issue>15</issue><spage>74</spage><epage>753</epage><pages>74-753</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Short-chain fatty acids (SCFAs) are involved in the regulation of a wide array of diseases. However, the effect of cereal dietary fibers on SCFA production remains unclear. We reviewed relevant clinical studies between 1950 and 2021 and aimed to evaluate the effect of cereal fiber consumption on SCFA production in healthy subjects and patients. PubMed, Web of Science, and the Cochrane Library databases were used for systematically searching published relevant trials with adults and a minimum intervention duration of 2 weeks. The effect size was estimated using standardized mean difference (SMD) and 95% confidence interval (CI). Of the 555 identified studies, 14 intervention groups involving 205 participants aged between 20 and 69 years are eligible. The results of meta-analysis revealed that cereal fiber supplementation significantly increased acetate [SMD: 0.86, 95% CI (0.46, 1.25),
p
< 0.0001], propionate [SMD: 0.48, 95% CI: (0.15, 0.81),
p
= 0.004], butyrate [SMD: 0.61, 95% CI: (0.20, 1.01),
p
= 0.003], and total SCFA [SMD, 0.96, 95% CI: (0.54, 1.39),
p
< 0.00001] concentrations. Subgroup analysis suggested that a long intervention duration (>4 weeks) significantly promoted acetate and propionate production, whereas a short intervention duration (≤4 weeks) significantly facilitated butyrate production. Cereal fiber supplementation had a more significant impact on overweight and obese subjects with body mass index (BMI) >29 kg m
−2
than on individuals with BMI ≤29 kg m
−2
. Furthermore, we found that cereal fibers and wheat/rye arabinoxylan oligosaccharides, rather than wheat bran fibers, barley fibers, and barley β-glucan, could significantly elevate the SCFA concentration. Overall, our meta-analysis demonstrated that cereal fiber supplementation is helpful in increasing the SCFA concentration, which provided strong proof for the beneficial role of cereal fibers.
Cereal fiber supplementation significantly affected fecal SCFA concentrations in randomized clinical studies. A more significant impact appeared in overweight and obese subjects with BMI >29 kg m
−2
than in individuals with BMI ≤29 kg m
−2
.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>34152334</pmid><doi>10.1039/d1fo00858g</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-4401-4207</orcidid><orcidid>https://orcid.org/0000-0002-9402-1093</orcidid><orcidid>https://orcid.org/0000-0003-0415-8748</orcidid></addata></record> |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Acetic acid Adult Aged Barley Body mass Body Mass Index Body size Body weight Body Weight - physiology Clinical trials Confidence intervals Diet Dietary fiber Dietary supplements Edible Grain Fatty acids Fatty Acids, Volatile - blood Female Fibers Glucan Humans Indexing Male Meta-analysis Middle Aged Oligosaccharides Overweight Patients Propionic acid Randomized Controlled Trials as Topic Rye Subgroups Wheat Wheat bran Young Adult β-Glucan |
| title | Effects of cereal fibers on short-chain fatty acids in healthy subjects and patients: a meta-analysis of randomized clinical trials |
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