Terpyridine copper() complexes as potential anticancer agents by inhibiting cell proliferation, blocking the cell cycle and inducing apoptosis in BEL-7402 cells

Four mononuclear terpyridine complexes [Cu(H-L a )Cl 2 ]·CH 3 OH ( 1 ), [Cu(H-L a )Cl]ClO 4 ( 2 ), [Cu(H-L b )Cl 2 ]·CH 3 OH ( 3 ), and [Cu(H-L b )(CH 3 OH)(DMSO)](ClO 4 ) 2 ( 4 ) were prepared and fully characterized. Complexes 1-4 exhibited higher cytotoxic activity against several tested cancer c...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2022-02, Vol.51 (5), p.1968-1978
Hauptverfasser:	Gu, Yun-Qiong, Zhong, Yu-Jun, Hu, Mei-Qi, Li, Huan-Qing, Yang, Kun, Dong, Qi, Liang, Hong, Chen, Zhen-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Apoptosis Calcium ions Cell cycle Coordination compounds Copper Copper compounds Cytochromes Mitochondria Toxicity Tumors Xenotransplantation
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