Site-selective and inducible acylation of thrombin using aptamer-catalyst conjugates

Two acyl-transfer catalysts were conjugated to thrombin-binding DNA aptamers to acylate thrombin. Modification occurred site-selectively on Lys (>Ser) residues proximal to the respective aptamer-thrombin interface, was selective for thrombin in the presence of other proteins, and the activity of...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2021-12, Vol.57 (96), p.1296-12963
Hauptverfasser:	Keijzer, Jordi F, Firet, Judith, Albada, Bauke
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Aptamers, Nucleotide - chemistry Catalysis Catalysts Models, Molecular Molecular Structure Thrombin Thrombin - chemical synthesis Thrombin - chemistry
Online-Zugang:	Volltext
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