An asymmetric oxidative cyclization/Mannich-type addition cascade reaction for direct access to chiral pyrrolidin-3-ones

An efficient gold and chiral phosphoric acid cooperatively catalyzed enantioselective oxidative cyclization/Mannich-type addition reaction of homopropargyl amides with nitrones has been developed, which provides chiral pyrrolidin-3-ones in high yields with excellent enantioselectivities under mild c...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2021-11, Vol.57 (91), p.12171-12174
Hauptverfasser:	Zhou, Su, Xie, Xiongda, Xu, Xinxin, Dong, Shanliang, Hu, Wenhao, Xu, Xinfang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Amides Cascade chemical reactions Enantiomers Phosphoric acid
Online-Zugang:	Volltext
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