Site-selective lysine conjugation methods and applications towards antibody-drug conjugates

Site-selective protein modification is of significant interest in chemical biology research, with lysine residues representing a particularly challenging target. Whilst lysines are popular for bioconjugation, due to their nucleophilicity, solvent accessibility and the stability of the resultant conj...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2021-10, Vol.57 (82), p.1689-172
Hauptverfasser:	Haque, Muhammed, Forte, Nafsika, Baker, James R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Binding Sites, Antibody Chemistry Conjugates Conjugation Cysteine - chemistry Humans Hydrophobic and Hydrophilic Interactions Immunoconjugates - chemistry Immunoconjugates - pharmacology Lysine Lysine - chemistry Oxidation-Reduction Protein Binding Protein Conformation Protein Engineering Protein Processing, Post-Translational Proteins Selectivity Structure-Activity Relationship
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