Chemical technologies for precise protein bioconjugation interfacing biology and medicine

Chemical technologies for precise protein bioconjugation interfacing biology and medicine

Proteins provide an excellent means to monitor and regulate biological processes. Hence, a precise chemical toolbox for their modification becomes indispensable. In this perspective, this feature article outlines our efforts to establish the core principles of chemoselectivity, site-selectivity, sit...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-07, Vol.57 (58), p.783-795
Hauptverfasser: Kumar, Mohan, Reddy, Neelesh C, Rai, Vishal
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Sprache:eng
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Biological activity
Biology
Biomonitoring
Medicine
Modularity
Proteins
Selectivity
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container_title Chemical communications (Cambridge, England)
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creator Kumar, Mohan
Reddy, Neelesh C
Rai, Vishal
description Proteins provide an excellent means to monitor and regulate biological processes. Hence, a precise chemical toolbox for their modification becomes indispensable. In this perspective, this feature article outlines our efforts to establish the core principles of chemoselectivity, site-selectivity, site-specificity, site-modularity, residue-modularity, and protein-specificity. With the knowledge to systematically regulate these parameters, the field has access to technological platforms that can address multiple challenges at the interface of chemistry, biology, and medicine. The methods to regulate the reactivity and various selectivity attributes enable the single-site modification of proteins.
doi_str_mv 10.1039/d1cc02268g
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Biological activity
Biology
Biomonitoring
Medicine
Modularity
Proteins
Selectivity
title Chemical technologies for precise protein bioconjugation interfacing biology and medicine
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