Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers
Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance. In this study, polycaprolactone (PCL)-based microspheres were...
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| Veröffentlicht in: | Biomaterials science 2022-02, Vol.1 (4), p.947-959 |
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| creator | Heo, Yun Shin, Sang-Woo Kim, Da-Seul Lee, Semi Park, So-Yeon Baek, Seung-Woon Lee, Jun-Kyu Kim, Jun Hyuk Han, Dong Keun |
| description | Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance. In this study, polycaprolactone (PCL)-based microspheres were produced with a uniform size of about 30-40 μm by utilizing a membrane emulsification device. MH from the PCL/MH microspheres effectively neutralized acidic products from PCL degradation. For
in vitro
cell experiments, when acidic degradation products (6-hydroxycaproic acid, HCA) were treated with MH, the acidic pH was neutralized to induce wound healing and suppress inflammation. The microspheres comprised of BA had a sustained release of the BA, without an initial burst release. Remarkably, the ATX added into the microspheres was maintained for 16 weeks and displayed positive attributes, such as tissue regeneration and collagen production improvement, as noted by
in vivo
testing. Overall, these results suggest that the bioactive PCL microspheres containing ATX have excellent potential as a functional dermal filler for skin aesthetics and facial plastic surgery.
Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance. |
| doi_str_mv | 10.1039/d1bm01846a |
| format | Article |
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in vitro
cell experiments, when acidic degradation products (6-hydroxycaproic acid, HCA) were treated with MH, the acidic pH was neutralized to induce wound healing and suppress inflammation. The microspheres comprised of BA had a sustained release of the BA, without an initial burst release. Remarkably, the ATX added into the microspheres was maintained for 16 weeks and displayed positive attributes, such as tissue regeneration and collagen production improvement, as noted by
in vivo
testing. Overall, these results suggest that the bioactive PCL microspheres containing ATX have excellent potential as a functional dermal filler for skin aesthetics and facial plastic surgery.
Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance.</description><identifier>ISSN: 2047-4830</identifier><identifier>EISSN: 2047-4849</identifier><identifier>DOI: 10.1039/d1bm01846a</identifier><identifier>PMID: 35043794</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Astaxanthin ; Biocompatibility ; Biological activity ; Biomedical materials ; Collagen ; Degradation ; Dermal Fillers ; Fillers ; Hyaluronic Acid ; In vivo methods and tests ; Magnesium hydroxide ; Microspheres ; Plastic surgery ; Polycaprolactone ; Polyesters ; Regeneration ; Skin ; Sustained release ; Tissue engineering ; Wound healing</subject><ispartof>Biomaterials science, 2022-02, Vol.1 (4), p.947-959</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-b1295fad797b906f20e037edf71f09b50015f84082b8950a7deab11b4e2aba403</citedby><cites>FETCH-LOGICAL-c337t-b1295fad797b906f20e037edf71f09b50015f84082b8950a7deab11b4e2aba403</cites><orcidid>0000-0003-4641-7883 ; 0000-0002-1816-0649 ; 0000-0002-6653-5783 ; 0000-0002-6574-0072 ; 0000-0002-6281-0434</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35043794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heo, Yun</creatorcontrib><creatorcontrib>Shin, Sang-Woo</creatorcontrib><creatorcontrib>Kim, Da-Seul</creatorcontrib><creatorcontrib>Lee, Semi</creatorcontrib><creatorcontrib>Park, So-Yeon</creatorcontrib><creatorcontrib>Baek, Seung-Woon</creatorcontrib><creatorcontrib>Lee, Jun-Kyu</creatorcontrib><creatorcontrib>Kim, Jun Hyuk</creatorcontrib><creatorcontrib>Han, Dong Keun</creatorcontrib><title>Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers</title><title>Biomaterials science</title><addtitle>Biomater Sci</addtitle><description>Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance. In this study, polycaprolactone (PCL)-based microspheres were produced with a uniform size of about 30-40 μm by utilizing a membrane emulsification device. MH from the PCL/MH microspheres effectively neutralized acidic products from PCL degradation. For
in vitro
cell experiments, when acidic degradation products (6-hydroxycaproic acid, HCA) were treated with MH, the acidic pH was neutralized to induce wound healing and suppress inflammation. The microspheres comprised of BA had a sustained release of the BA, without an initial burst release. Remarkably, the ATX added into the microspheres was maintained for 16 weeks and displayed positive attributes, such as tissue regeneration and collagen production improvement, as noted by
in vivo
testing. Overall, these results suggest that the bioactive PCL microspheres containing ATX have excellent potential as a functional dermal filler for skin aesthetics and facial plastic surgery.
Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance.</description><subject>Astaxanthin</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Biomedical materials</subject><subject>Collagen</subject><subject>Degradation</subject><subject>Dermal Fillers</subject><subject>Fillers</subject><subject>Hyaluronic Acid</subject><subject>In vivo methods and tests</subject><subject>Magnesium hydroxide</subject><subject>Microspheres</subject><subject>Plastic surgery</subject><subject>Polycaprolactone</subject><subject>Polyesters</subject><subject>Regeneration</subject><subject>Skin</subject><subject>Sustained release</subject><subject>Tissue engineering</subject><subject>Wound healing</subject><issn>2047-4830</issn><issn>2047-4849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctPGzEQxq2qqCDg0nsrS72gSoHxY-PdI4S-pFRwoOeVH-PGaHcd7F2qnPjXaxIapM7FM_ZPn77xR8h7BucMRHPhmOmB1XKu35AjDlLNZC2bt_tewCE5zfkeSinVwJy9I4eiAilUI4_I01WI2o7hEentYkn7YFPM6xUmzPRPGFcUh5UeLDpqQrSxX-sxmNCFcUP14KiNXad_40DXKbqp6MSB-pion4btoDu62uhuSnEIlmobHHWY-nLtQ9dhyifkwOsu4-nLeUx-ff1yt_g-W958-7G4XM6sEGqcGcabymunGmXKDp4DglDovGIeGlMBsMrXEmpu6qYCrRxqw5iRyLXREsQxOdvpFqMPE-ax7UO2WNwPGKfc8jlnvALOWUE__YfexymVVbZUreqq3gp-3lHPH5YT-nadQq_TpmXQPifTXrOrn9tkLgv88UVyMj26PfovhwJ82AEp2_3ra7TiL6zylAY</recordid><startdate>20220215</startdate><enddate>20220215</enddate><creator>Heo, Yun</creator><creator>Shin, Sang-Woo</creator><creator>Kim, Da-Seul</creator><creator>Lee, Semi</creator><creator>Park, So-Yeon</creator><creator>Baek, Seung-Woon</creator><creator>Lee, Jun-Kyu</creator><creator>Kim, Jun Hyuk</creator><creator>Han, Dong Keun</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4641-7883</orcidid><orcidid>https://orcid.org/0000-0002-1816-0649</orcidid><orcidid>https://orcid.org/0000-0002-6653-5783</orcidid><orcidid>https://orcid.org/0000-0002-6574-0072</orcidid><orcidid>https://orcid.org/0000-0002-6281-0434</orcidid></search><sort><creationdate>20220215</creationdate><title>Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers</title><author>Heo, Yun ; Shin, Sang-Woo ; Kim, Da-Seul ; Lee, Semi ; Park, So-Yeon ; Baek, Seung-Woon ; Lee, Jun-Kyu ; Kim, Jun Hyuk ; Han, Dong Keun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-b1295fad797b906f20e037edf71f09b50015f84082b8950a7deab11b4e2aba403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Astaxanthin</topic><topic>Biocompatibility</topic><topic>Biological activity</topic><topic>Biomedical materials</topic><topic>Collagen</topic><topic>Degradation</topic><topic>Dermal Fillers</topic><topic>Fillers</topic><topic>Hyaluronic Acid</topic><topic>In vivo methods and tests</topic><topic>Magnesium hydroxide</topic><topic>Microspheres</topic><topic>Plastic surgery</topic><topic>Polycaprolactone</topic><topic>Polyesters</topic><topic>Regeneration</topic><topic>Skin</topic><topic>Sustained release</topic><topic>Tissue engineering</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heo, Yun</creatorcontrib><creatorcontrib>Shin, Sang-Woo</creatorcontrib><creatorcontrib>Kim, Da-Seul</creatorcontrib><creatorcontrib>Lee, Semi</creatorcontrib><creatorcontrib>Park, So-Yeon</creatorcontrib><creatorcontrib>Baek, Seung-Woon</creatorcontrib><creatorcontrib>Lee, Jun-Kyu</creatorcontrib><creatorcontrib>Kim, Jun Hyuk</creatorcontrib><creatorcontrib>Han, Dong Keun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heo, Yun</au><au>Shin, Sang-Woo</au><au>Kim, Da-Seul</au><au>Lee, Semi</au><au>Park, So-Yeon</au><au>Baek, Seung-Woon</au><au>Lee, Jun-Kyu</au><au>Kim, Jun Hyuk</au><au>Han, Dong Keun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers</atitle><jtitle>Biomaterials science</jtitle><addtitle>Biomater Sci</addtitle><date>2022-02-15</date><risdate>2022</risdate><volume>1</volume><issue>4</issue><spage>947</spage><epage>959</epage><pages>947-959</pages><issn>2047-4830</issn><eissn>2047-4849</eissn><abstract>Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance. In this study, polycaprolactone (PCL)-based microspheres were produced with a uniform size of about 30-40 μm by utilizing a membrane emulsification device. MH from the PCL/MH microspheres effectively neutralized acidic products from PCL degradation. For
in vitro
cell experiments, when acidic degradation products (6-hydroxycaproic acid, HCA) were treated with MH, the acidic pH was neutralized to induce wound healing and suppress inflammation. The microspheres comprised of BA had a sustained release of the BA, without an initial burst release. Remarkably, the ATX added into the microspheres was maintained for 16 weeks and displayed positive attributes, such as tissue regeneration and collagen production improvement, as noted by
in vivo
testing. Overall, these results suggest that the bioactive PCL microspheres containing ATX have excellent potential as a functional dermal filler for skin aesthetics and facial plastic surgery.
Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35043794</pmid><doi>10.1039/d1bm01846a</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-4641-7883</orcidid><orcidid>https://orcid.org/0000-0002-1816-0649</orcidid><orcidid>https://orcid.org/0000-0002-6653-5783</orcidid><orcidid>https://orcid.org/0000-0002-6574-0072</orcidid><orcidid>https://orcid.org/0000-0002-6281-0434</orcidid></addata></record> |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Astaxanthin Biocompatibility Biological activity Biomedical materials Collagen Degradation Dermal Fillers Fillers Hyaluronic Acid In vivo methods and tests Magnesium hydroxide Microspheres Plastic surgery Polycaprolactone Polyesters Regeneration Skin Sustained release Tissue engineering Wound healing |
| title | Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers |
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