Hyaluronic acid-amphotericin B nanocomplexes: a promising anti-leishmanial drug delivery system

The development of an effective amphotericin B (AmB) formulation to replace actual treatments available for leishmaniasis, which present serious drawbacks, is a challenge. Here we report the development of hyaluronic acid-amphotericin B self-assembled nanocomplexes (HA-AmB), processed by freeze-dryi...

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Veröffentlicht in:	Biomaterials science 2022-04, Vol.1 (8), p.1952-1967
Hauptverfasser:	Silva-Carvalho, R, Leão, T, Bourbon, A. I, Gonçalves, C, Pastrana, L. M, Parpot, P, Amorim, I, Tomás, A. M, Gama, F. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - pharmacology Animals Drug Delivery Systems Drying Hyaluronic acid Hyaluronic Acid - therapeutic use Leishmaniasis - drug therapy Liver Mice Mice, Inbred C57BL Parasitic diseases Polysaccharides Selectivity Self-assembly Spleen Stability Toxicity Zeta potential
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