Heteroditopic chemosensor to detect γ-hydroxybutyric acid (GHB) in soft drinks and alcoholic beverages
Drug-Facilitated Sexual Assault (DFSA) is a problem of considerable dimensions on a global scale. Among the different compounds used in DFSA assaults, 4-hydroxybutyric acid (GHB) is one of the most elusive due to its physical and biological characteristics. Therefore, the development of real-time de...
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| Veröffentlicht in: | Analyst (London) 2021-09, Vol.146 (18), p.561-569 |
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| creator | Rodríguez-Nuévalos, Silvia Parra, Margarita Gil, Salvador Gaviña, Pablo Arroyo, Pau Sáez, José A Costero, Ana M |
| description | Drug-Facilitated Sexual Assault (DFSA) is a problem of considerable dimensions on a global scale. Among the different compounds used in DFSA assaults, 4-hydroxybutyric acid (GHB) is one of the most elusive due to its physical and biological characteristics. Therefore, the development of real-time detection methods to detect GHB not only in drinks but also in urine is very important for personal and social security. Here, we report two new heteroditopic chemosensors capable of recognizing and detecting GHB in soft drinks, alcoholic beverages and synthetic urine. The compounds have two moieties: a trifluoroacetyl group and a thiourea, which are able to interact respectively with the hydroxyl and the carboxylic groups present in the GHB structure. In addition, the distance between these two groups has been optimized to allow a double interaction which guarantees the recognition even in very competitive media such as beverages or urine samples.
Visual detection of 4-hydroxybutiric acid in beverages can increase personal security against Drug-Facilitated Sexual Assault (DFSA). |
| doi_str_mv | 10.1039/d1an01084k |
| format | Article |
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Visual detection of 4-hydroxybutiric acid in beverages can increase personal security against Drug-Facilitated Sexual Assault (DFSA).</description><subject>Alcoholic beverages</subject><subject>Beverages</subject><subject>Chemical sensors</subject><subject>Chemoreceptors</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Sex crimes</subject><subject>Social security</subject><subject>Soft drinks</subject><subject>Titration</subject><subject>Urine</subject><issn>0003-2654</issn><issn>1364-5528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpd0cFOAyEQAFBiNLFWL95NSLxUk1VYYFmOtWprbPSi5w0LbLvtdqnAGvtd_offJFqjiafJhDcTZgaAY4wuMCLiUmPZIoxyutwBPUwymjCW5rughxAiSZoxug8OvF_EFCOGemA2McE4q-tg17WCam5W1pvWWweDhTo-qgA_3pP5Rjv7tim7sHHRSVVrOBhPrs5g3UJvqwC1q9ulh7LVUDbKzm0TXWlejZMz4w_BXiUbb45-Yh883948jSbJ9HF8NxpOE0UwDQnRJJWCGM4FlZyJskJpJjknQhqWcWbKOFSak9KQCnGe6SxXOaacy1KwKlb3wWDbd-3sS2d8KFa1V6ZpZGts54uUZSgVOeZ5pKf_6MJ2ro2_i4pjgQilPKrzrVLOeu9MVaxdvZJuU2BUfO28uMbDh--d30d8ssXOq1_3dxPyCdMxfeU</recordid><startdate>20210913</startdate><enddate>20210913</enddate><creator>Rodríguez-Nuévalos, Silvia</creator><creator>Parra, Margarita</creator><creator>Gil, Salvador</creator><creator>Gaviña, Pablo</creator><creator>Arroyo, Pau</creator><creator>Sáez, José A</creator><creator>Costero, Ana M</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8496-6448</orcidid><orcidid>https://orcid.org/0000-0001-9640-1148</orcidid><orcidid>https://orcid.org/0000-0002-2818-1320</orcidid><orcidid>https://orcid.org/0000-0002-7797-7077</orcidid></search><sort><creationdate>20210913</creationdate><title>Heteroditopic chemosensor to detect γ-hydroxybutyric acid (GHB) in soft drinks and alcoholic beverages</title><author>Rodríguez-Nuévalos, Silvia ; Parra, Margarita ; Gil, Salvador ; Gaviña, Pablo ; Arroyo, Pau ; Sáez, José A ; Costero, Ana M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-3d32a93e7794a759bf026a7739ae5675eb136283be3f0776d68c81477ab95f3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alcoholic beverages</topic><topic>Beverages</topic><topic>Chemical sensors</topic><topic>Chemoreceptors</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Sex crimes</topic><topic>Social security</topic><topic>Soft drinks</topic><topic>Titration</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodríguez-Nuévalos, Silvia</creatorcontrib><creatorcontrib>Parra, Margarita</creatorcontrib><creatorcontrib>Gil, Salvador</creatorcontrib><creatorcontrib>Gaviña, Pablo</creatorcontrib><creatorcontrib>Arroyo, Pau</creatorcontrib><creatorcontrib>Sáez, José A</creatorcontrib><creatorcontrib>Costero, Ana M</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Analyst (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodríguez-Nuévalos, Silvia</au><au>Parra, Margarita</au><au>Gil, Salvador</au><au>Gaviña, Pablo</au><au>Arroyo, Pau</au><au>Sáez, José A</au><au>Costero, Ana M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heteroditopic chemosensor to detect γ-hydroxybutyric acid (GHB) in soft drinks and alcoholic beverages</atitle><jtitle>Analyst (London)</jtitle><date>2021-09-13</date><risdate>2021</risdate><volume>146</volume><issue>18</issue><spage>561</spage><epage>569</epage><pages>561-569</pages><issn>0003-2654</issn><eissn>1364-5528</eissn><abstract>Drug-Facilitated Sexual Assault (DFSA) is a problem of considerable dimensions on a global scale. 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Visual detection of 4-hydroxybutiric acid in beverages can increase personal security against Drug-Facilitated Sexual Assault (DFSA).</abstract><cop>London</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d1an01084k</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8496-6448</orcidid><orcidid>https://orcid.org/0000-0001-9640-1148</orcidid><orcidid>https://orcid.org/0000-0002-2818-1320</orcidid><orcidid>https://orcid.org/0000-0002-7797-7077</orcidid></addata></record> |
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| source | Royal Society of Chemistry Journals Archive (1841-2007); Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Alcoholic beverages Beverages Chemical sensors Chemoreceptors NMR Nuclear magnetic resonance Sex crimes Social security Soft drinks Titration Urine |
| title | Heteroditopic chemosensor to detect γ-hydroxybutyric acid (GHB) in soft drinks and alcoholic beverages |
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