An efficient delivery of photosensitizers and hypoxic prodrugs for a tumor combination therapy by membrane camouflage nanoparticles

Photodynamic therapy (PDT) is an oxygen-dependent, non-invasive cancer treatment. The hypoxia in the tumor environment limits the therapeutic effects of PDT. The combined delivery of photosensitizers and hypoxic prodrugs is expected to improve the efficacy of tumor treatment. In this paper, an eryth...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-04, Vol.8 (14), p.2876-2886
Hauptverfasser:	Wang, Hanjie, Zhang, Chaonan, Zhang, Yingying, Tian, Ran, Cheng, Guohui, Pan, Huizhuo, Cui, Meihui, Chang, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Camouflage Cancer Cell death Cell Hypoxia - drug effects Cell Membrane - drug effects Cell membranes Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Chemical compounds Chemotherapy Combined Modality Therapy Drug Delivery Systems Drug Screening Assays, Antitumor Drugs Environmental effects Erythrocytes Humans Hypoxia Indocyanine Green - chemistry Indocyanine Green - pharmacology Irradiation Macrophages Membranes Mice Mice, Inbred BALB C Nanoparticles Nanoparticles - chemistry Near infrared radiation Optical Imaging Photochemotherapy Photodynamic therapy Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Prodrugs Prodrugs - chemistry Prodrugs - pharmacology Radiation RAW 264.7 Cells Tirapazamine Tirapazamine - chemistry Tirapazamine - pharmacology Tumor cells Tumors
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