Click activated protodrugs against cancer increase the therapeutic potential of chemotherapy through local capture and activation

A desired goal of targeted cancer treatments is to achieve high tumor specificity with minimal side effects. Despite recent advances, this remains difficult to achieve in practice as most approaches rely on biomarkers or physiological differences between malignant and healthy tissue, and thus benefi...

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Veröffentlicht in:Chemical science (Cambridge) 2021-01, Vol.12 (4), p.1259-1271
Hauptverfasser: Wu, Kui, Yee, Nathan A, Srinivasan, Sangeetha, Mahmoodi, Amir, Zakharian, Michael, Mejia Oneto, Jose M, Royzen, Maksim
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Sprache:eng
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