Encoded, click-reactive DNA-binding domains for programmable capture of specific chromatin segments

Enrichment of chromatin segments from specific genomic loci of living cells is an important goal in chromatin biology, since it enables establishing local molecular compositions as the basis of locus function. A central enrichment strategy relies on the expression of DNA-binding domains that selecti...

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Veröffentlicht in:	Chemical science (Cambridge) 2020-12, Vol.11 (46), p.1256-12511
Hauptverfasser:	Witte, Anna, Muñoz-López, Álvaro, Metz, Malte, Schweiger, Michal R, Janning, Petra, Summerer, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes Alkynes Binding Chemical composition Chemistry Deoxyribonucleic acid DNA Enrichment Gene expression Genetic code Heat stress Loci Proteins Segments Selectivity
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