Phototheranostic DNA micelles from the self-assembly of DNA-BODIPY amphiphiles for the thermal ablation of cancer cells
Design of phototheranostic agents in a single step approach is one of the challenges in cancer therapy. Herein, a one-step strategy based on amphiphilicity-driven self-assembly of DNA-BODIPY amphiphiles for the design of a new class of micelles, which offer all three phototheranostic functions, is r...
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| Veröffentlicht in: | Nanoscale 2020-06, Vol.12 (22), p.11858-11862 |
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| container_title | Nanoscale |
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| creator | Atchimnaidu, Siriki Perumal, Devanathan Harikrishanan, Kaloor S Thelu, Hari Veera Prasad Varghese, Reji |
| description | Design of phototheranostic agents in a single step approach is one of the challenges in cancer therapy. Herein, a one-step strategy based on amphiphilicity-driven self-assembly of DNA-BODIPY amphiphiles for the design of a new class of micelles, which offer all three phototheranostic functions, is reported. These include (i) strong emission at NIR (
f
= 30%) for imaging, (ii) high photothermal conversion (
η
= 52%) for PTT and (iii) an ssDNA-based shell for the integration of cell targeting moieties. Selective uptake of DNA micelles into a target cancer cell and its killing by laser irradiation (635 nm) are also demonstrated. Furthermore, the excellent biocompatibility, ultrasmall nanosize and high stability of DNA micelles are promising for
in vivo
applications.
A one-step strategy based on amphiphilicity-driven self-assembly of DNA-BODIPY amphiphiles for the design of a new class of DNA micelles, which offer all three phototheranostic functions in a single nanoentity, is reported. |
| doi_str_mv | 10.1039/d0nr02622k |
| format | Article |
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f
= 30%) for imaging, (ii) high photothermal conversion (
η
= 52%) for PTT and (iii) an ssDNA-based shell for the integration of cell targeting moieties. Selective uptake of DNA micelles into a target cancer cell and its killing by laser irradiation (635 nm) are also demonstrated. Furthermore, the excellent biocompatibility, ultrasmall nanosize and high stability of DNA micelles are promising for
in vivo
applications.
A one-step strategy based on amphiphilicity-driven self-assembly of DNA-BODIPY amphiphiles for the design of a new class of DNA micelles, which offer all three phototheranostic functions in a single nanoentity, is reported.</description><identifier>ISSN: 2040-3364</identifier><identifier>EISSN: 2040-3372</identifier><identifier>DOI: 10.1039/d0nr02622k</identifier><identifier>PMID: 32484195</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Ablation ; Biocompatibility ; Boron Compounds ; Cancer ; Deoxyribonucleic acid ; DNA ; Hyperthermia, Induced ; Micelles ; Neoplasms - therapy ; Photothermal conversion ; Self-assembly</subject><ispartof>Nanoscale, 2020-06, Vol.12 (22), p.11858-11862</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-19ada0e1266e92d8b88b5fadc7f2da5e66f7c882c449085a755b56e4002247ae3</citedby><cites>FETCH-LOGICAL-c363t-19ada0e1266e92d8b88b5fadc7f2da5e66f7c882c449085a755b56e4002247ae3</cites><orcidid>0000-0002-8513-9954</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32484195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Atchimnaidu, Siriki</creatorcontrib><creatorcontrib>Perumal, Devanathan</creatorcontrib><creatorcontrib>Harikrishanan, Kaloor S</creatorcontrib><creatorcontrib>Thelu, Hari Veera Prasad</creatorcontrib><creatorcontrib>Varghese, Reji</creatorcontrib><title>Phototheranostic DNA micelles from the self-assembly of DNA-BODIPY amphiphiles for the thermal ablation of cancer cells</title><title>Nanoscale</title><addtitle>Nanoscale</addtitle><description>Design of phototheranostic agents in a single step approach is one of the challenges in cancer therapy. Herein, a one-step strategy based on amphiphilicity-driven self-assembly of DNA-BODIPY amphiphiles for the design of a new class of micelles, which offer all three phototheranostic functions, is reported. These include (i) strong emission at NIR (
f
= 30%) for imaging, (ii) high photothermal conversion (
η
= 52%) for PTT and (iii) an ssDNA-based shell for the integration of cell targeting moieties. Selective uptake of DNA micelles into a target cancer cell and its killing by laser irradiation (635 nm) are also demonstrated. Furthermore, the excellent biocompatibility, ultrasmall nanosize and high stability of DNA micelles are promising for
in vivo
applications.
A one-step strategy based on amphiphilicity-driven self-assembly of DNA-BODIPY amphiphiles for the design of a new class of DNA micelles, which offer all three phototheranostic functions in a single nanoentity, is reported.</description><subject>Ablation</subject><subject>Biocompatibility</subject><subject>Boron Compounds</subject><subject>Cancer</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Hyperthermia, Induced</subject><subject>Micelles</subject><subject>Neoplasms - therapy</subject><subject>Photothermal conversion</subject><subject>Self-assembly</subject><issn>2040-3364</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c9LwzAUB_AgipvTi3cl4kWEapqkaXucmz-GYxuiB08lTRPW2TYzaZH996bbnOBBCCTwPu_LIw-AUx_d-IjEtxmqDMIM44890MWIIo-QEO_v3ox2wJG1C4RYTBg5BB2CaUT9OOiCr9lc17qeS8MrbetcwOGkD8tcyKKQFiqjS-iq0MpCedxaWabFCmrVMu9uOhzN3iEvl_PcnXWDNmvfJpa8gDwteJ3rqm0RvBLSwDbaHoMDxQsrT7Z3D7w93L8Onrzx9HE06I894SatPT_mGUfSx4zJGGdRGkVpoHgmQoUzHkjGVCiiCAtKYxQFPAyCNGCSIoQxDbkkPXC1yV0a_dlIWydlbtsJeCV1YxNMkWvHYYgdvfxDF7oxlZvOKd-nEaGIOXW9UcJoa41UydLkJTerxEdJu45kiCYv63U8O3y-jWzSUmY7-vP_DlxsgLFiV_3dZ7LMlDNn_xnyDUO7meQ</recordid><startdate>20200611</startdate><enddate>20200611</enddate><creator>Atchimnaidu, Siriki</creator><creator>Perumal, Devanathan</creator><creator>Harikrishanan, Kaloor S</creator><creator>Thelu, Hari Veera Prasad</creator><creator>Varghese, Reji</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8513-9954</orcidid></search><sort><creationdate>20200611</creationdate><title>Phototheranostic DNA micelles from the self-assembly of DNA-BODIPY amphiphiles for the thermal ablation of cancer cells</title><author>Atchimnaidu, Siriki ; Perumal, Devanathan ; Harikrishanan, Kaloor S ; Thelu, Hari Veera Prasad ; Varghese, Reji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-19ada0e1266e92d8b88b5fadc7f2da5e66f7c882c449085a755b56e4002247ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Ablation</topic><topic>Biocompatibility</topic><topic>Boron Compounds</topic><topic>Cancer</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Hyperthermia, Induced</topic><topic>Micelles</topic><topic>Neoplasms - therapy</topic><topic>Photothermal conversion</topic><topic>Self-assembly</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Atchimnaidu, Siriki</creatorcontrib><creatorcontrib>Perumal, Devanathan</creatorcontrib><creatorcontrib>Harikrishanan, Kaloor S</creatorcontrib><creatorcontrib>Thelu, Hari Veera Prasad</creatorcontrib><creatorcontrib>Varghese, Reji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Atchimnaidu, Siriki</au><au>Perumal, Devanathan</au><au>Harikrishanan, Kaloor S</au><au>Thelu, Hari Veera Prasad</au><au>Varghese, Reji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phototheranostic DNA micelles from the self-assembly of DNA-BODIPY amphiphiles for the thermal ablation of cancer cells</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2020-06-11</date><risdate>2020</risdate><volume>12</volume><issue>22</issue><spage>11858</spage><epage>11862</epage><pages>11858-11862</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>Design of phototheranostic agents in a single step approach is one of the challenges in cancer therapy. Herein, a one-step strategy based on amphiphilicity-driven self-assembly of DNA-BODIPY amphiphiles for the design of a new class of micelles, which offer all three phototheranostic functions, is reported. These include (i) strong emission at NIR (
f
= 30%) for imaging, (ii) high photothermal conversion (
η
= 52%) for PTT and (iii) an ssDNA-based shell for the integration of cell targeting moieties. Selective uptake of DNA micelles into a target cancer cell and its killing by laser irradiation (635 nm) are also demonstrated. Furthermore, the excellent biocompatibility, ultrasmall nanosize and high stability of DNA micelles are promising for
in vivo
applications.
A one-step strategy based on amphiphilicity-driven self-assembly of DNA-BODIPY amphiphiles for the design of a new class of DNA micelles, which offer all three phototheranostic functions in a single nanoentity, is reported.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32484195</pmid><doi>10.1039/d0nr02622k</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-8513-9954</orcidid></addata></record> |
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| ispartof | Nanoscale, 2020-06, Vol.12 (22), p.11858-11862 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Ablation Biocompatibility Boron Compounds Cancer Deoxyribonucleic acid DNA Hyperthermia, Induced Micelles Neoplasms - therapy Photothermal conversion Self-assembly |
| title | Phototheranostic DNA micelles from the self-assembly of DNA-BODIPY amphiphiles for the thermal ablation of cancer cells |
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