Employing chemical synthesis to study the structure and function of colibactin, a "dark matter" metabolite

Covering: 2015 to 2020 The field of natural products is dominated by a discovery paradigm that follows the sequence: isolation, structure elucidation, chemical synthesis, and then elucidation of mechanism of action and structure-activity relationships. Although this discovery paradigm has proven suc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Natural product reports 2020-11, Vol.37 (11), p.1532-1548
Hauptverfasser:	Williams, Peyton C, Wernke, Kevin M, Tirla, Alina, Herzon, Seth B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Products - chemistry Biological Products - pharmacology Chemical synthesis Dark matter Escherichia coli Proteins - genetics Fermentation Gene clusters Humans Metabolites Molecular Structure Mutation Natural products Peptide Hydrolases - genetics Peptides - chemical synthesis Peptides - chemistry Peptides - genetics Peptides - pharmacology Polyketides - chemical synthesis Polyketides - chemistry Polyketides - pharmacology Pyridones - chemistry Secondary metabolites Structure-Activity Relationship Structure-function relationships
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!