Preparation, biodistribution and dosimetry study of Tc-99m labeled N-doped graphene quantum dot nanoparticles as a multimodular radiolabeling agent
A new Tc-99m N-doped graphene quantum dot 99m Tc-(N-GQD) moiety was developed as a radiolabeling agent for molecules lacking chelation or water solubility of ligands simultaneously. (N-GQDs) were synthesized and characterized with high purity (size range = 5-10 nm). After radiolabeling, ITLC demonst...
Gespeichert in:
| Veröffentlicht in: | New journal of chemistry 2021-03, Vol.45 (8), p.399-3919 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3919 |
|---|---|
| container_issue | 8 |
| container_start_page | 399 |
| container_title | New journal of chemistry |
| container_volume | 45 |
| creator | Gharepapagh, Esmaeil Fakhari, Ashraf Firuzyar, Tahereh Shomali, Ashkan Azimi, Farzaneh |
| description | A new Tc-99m N-doped graphene quantum dot
99m
Tc-(N-GQD) moiety was developed as a radiolabeling agent for molecules lacking chelation or water solubility of ligands simultaneously. (N-GQDs) were synthesized and characterized with high purity (size range = 5-10 nm). After radiolabeling, ITLC demonstrated that the
99m
Tc-(N-GQDs) were prepared with high radiochemical purity (RCP ≥ 95%). Filtration of
99m
Tc-(N-GQDs) with a 0.1 μm filter proved that 77.38% of the particles were less than 0.1 μm.
99m
Tc-(N-GQDs) were injected into healthy Wistar rats for biodistribution studies. Results showed that
99m
Tc-(N-GQDs) were eliminated by the kidneys, and accumulated in the spleen due to the particle size of
99m
Tc-(N-GQDs). The ovaries and uterus showed a greater concentration of
99m
Tc-(N-GQDs) within 2 h after injection compared with other organs. Dosimetry studies were done to find out the effective radiation dose of each organ, and introduced the kidneys as critical organs. This research has demonstrated the profound feasible production of
99m
Tc-(N-GQDs) for possible radiolabeling of molecules with chelation limitations and poor water solubility.
Preparation, dosimetry and biodistribution study of
99m
Tc-(N-GQDs) as multipurpose nanoparticles. |
| doi_str_mv | 10.1039/d0nj04762g |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_D0NJ04762G</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2494165363</sourcerecordid><originalsourceid>FETCH-LOGICAL-c322t-a06743735a8fcdd0fa909a5c447f264fcd4d6b9dcbc80b5187c55ef26f8fa183</originalsourceid><addsrcrecordid>eNpFkU1LxDAQhoso-HnxLgS8idWkSdPmKKuuiqiHvZdpkq5Z2qSbpIf9Hf5hs64oDLzDzDPvwEyWnRN8QzAVtwrbFWYVL5Z72RGhXOSi4GQ_5YSxHJeMH2bHIawwJqTi5Cj7-vB6BA_ROHuNWuOUCdGbdtoWEFiFlAtm0NFvUIiT2iDXoYXMhRhQD63utUJvuXJj0qWH8VNbjdYT2DgNaTQiC9alBdHIXgcEKdAw9dEMTk09eORBGffjZOwSwVLbeJoddNAHffarJ9ni8WExe8pf3-fPs7vXXNKiiDlgXjFa0RLqTiqFOxBYQCkZq7qCs1RjirdCyVbWuC1JXcmy1KnV1R2Qmp5klzvb0bv1pENsVm7yNm1sCiYY4SXlNFFXO0p6F4LXXTN6M4DfNAQ325s39_jt5efm8wRf7GAf5B_3_xP6Da0PgaM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2494165363</pqid></control><display><type>article</type><title>Preparation, biodistribution and dosimetry study of Tc-99m labeled N-doped graphene quantum dot nanoparticles as a multimodular radiolabeling agent</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Gharepapagh, Esmaeil ; Fakhari, Ashraf ; Firuzyar, Tahereh ; Shomali, Ashkan ; Azimi, Farzaneh</creator><creatorcontrib>Gharepapagh, Esmaeil ; Fakhari, Ashraf ; Firuzyar, Tahereh ; Shomali, Ashkan ; Azimi, Farzaneh</creatorcontrib><description>A new Tc-99m N-doped graphene quantum dot
99m
Tc-(N-GQD) moiety was developed as a radiolabeling agent for molecules lacking chelation or water solubility of ligands simultaneously. (N-GQDs) were synthesized and characterized with high purity (size range = 5-10 nm). After radiolabeling, ITLC demonstrated that the
99m
Tc-(N-GQDs) were prepared with high radiochemical purity (RCP ≥ 95%). Filtration of
99m
Tc-(N-GQDs) with a 0.1 μm filter proved that 77.38% of the particles were less than 0.1 μm.
99m
Tc-(N-GQDs) were injected into healthy Wistar rats for biodistribution studies. Results showed that
99m
Tc-(N-GQDs) were eliminated by the kidneys, and accumulated in the spleen due to the particle size of
99m
Tc-(N-GQDs). The ovaries and uterus showed a greater concentration of
99m
Tc-(N-GQDs) within 2 h after injection compared with other organs. Dosimetry studies were done to find out the effective radiation dose of each organ, and introduced the kidneys as critical organs. This research has demonstrated the profound feasible production of
99m
Tc-(N-GQDs) for possible radiolabeling of molecules with chelation limitations and poor water solubility.
Preparation, dosimetry and biodistribution study of
99m
Tc-(N-GQDs) as multipurpose nanoparticles.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/d0nj04762g</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Chelation ; Dosimeters ; Dosimetry ; Graphene ; Kidneys ; Nanoparticles ; Organs ; Ovaries ; Purity ; Quantum dots ; Radiation dosage ; Radiochemistry ; Radiolabelling ; Solubility ; Spleen ; Uterus</subject><ispartof>New journal of chemistry, 2021-03, Vol.45 (8), p.399-3919</ispartof><rights>Copyright Royal Society of Chemistry 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c322t-a06743735a8fcdd0fa909a5c447f264fcd4d6b9dcbc80b5187c55ef26f8fa183</citedby><cites>FETCH-LOGICAL-c322t-a06743735a8fcdd0fa909a5c447f264fcd4d6b9dcbc80b5187c55ef26f8fa183</cites><orcidid>0000-0002-1732-5544</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Gharepapagh, Esmaeil</creatorcontrib><creatorcontrib>Fakhari, Ashraf</creatorcontrib><creatorcontrib>Firuzyar, Tahereh</creatorcontrib><creatorcontrib>Shomali, Ashkan</creatorcontrib><creatorcontrib>Azimi, Farzaneh</creatorcontrib><title>Preparation, biodistribution and dosimetry study of Tc-99m labeled N-doped graphene quantum dot nanoparticles as a multimodular radiolabeling agent</title><title>New journal of chemistry</title><description>A new Tc-99m N-doped graphene quantum dot
99m
Tc-(N-GQD) moiety was developed as a radiolabeling agent for molecules lacking chelation or water solubility of ligands simultaneously. (N-GQDs) were synthesized and characterized with high purity (size range = 5-10 nm). After radiolabeling, ITLC demonstrated that the
99m
Tc-(N-GQDs) were prepared with high radiochemical purity (RCP ≥ 95%). Filtration of
99m
Tc-(N-GQDs) with a 0.1 μm filter proved that 77.38% of the particles were less than 0.1 μm.
99m
Tc-(N-GQDs) were injected into healthy Wistar rats for biodistribution studies. Results showed that
99m
Tc-(N-GQDs) were eliminated by the kidneys, and accumulated in the spleen due to the particle size of
99m
Tc-(N-GQDs). The ovaries and uterus showed a greater concentration of
99m
Tc-(N-GQDs) within 2 h after injection compared with other organs. Dosimetry studies were done to find out the effective radiation dose of each organ, and introduced the kidneys as critical organs. This research has demonstrated the profound feasible production of
99m
Tc-(N-GQDs) for possible radiolabeling of molecules with chelation limitations and poor water solubility.
Preparation, dosimetry and biodistribution study of
99m
Tc-(N-GQDs) as multipurpose nanoparticles.</description><subject>Chelation</subject><subject>Dosimeters</subject><subject>Dosimetry</subject><subject>Graphene</subject><subject>Kidneys</subject><subject>Nanoparticles</subject><subject>Organs</subject><subject>Ovaries</subject><subject>Purity</subject><subject>Quantum dots</subject><subject>Radiation dosage</subject><subject>Radiochemistry</subject><subject>Radiolabelling</subject><subject>Solubility</subject><subject>Spleen</subject><subject>Uterus</subject><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpFkU1LxDAQhoso-HnxLgS8idWkSdPmKKuuiqiHvZdpkq5Z2qSbpIf9Hf5hs64oDLzDzDPvwEyWnRN8QzAVtwrbFWYVL5Z72RGhXOSi4GQ_5YSxHJeMH2bHIawwJqTi5Cj7-vB6BA_ROHuNWuOUCdGbdtoWEFiFlAtm0NFvUIiT2iDXoYXMhRhQD63utUJvuXJj0qWH8VNbjdYT2DgNaTQiC9alBdHIXgcEKdAw9dEMTk09eORBGffjZOwSwVLbeJoddNAHffarJ9ni8WExe8pf3-fPs7vXXNKiiDlgXjFa0RLqTiqFOxBYQCkZq7qCs1RjirdCyVbWuC1JXcmy1KnV1R2Qmp5klzvb0bv1pENsVm7yNm1sCiYY4SXlNFFXO0p6F4LXXTN6M4DfNAQ325s39_jt5efm8wRf7GAf5B_3_xP6Da0PgaM</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Gharepapagh, Esmaeil</creator><creator>Fakhari, Ashraf</creator><creator>Firuzyar, Tahereh</creator><creator>Shomali, Ashkan</creator><creator>Azimi, Farzaneh</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>H9R</scope><scope>JG9</scope><scope>KA0</scope><orcidid>https://orcid.org/0000-0002-1732-5544</orcidid></search><sort><creationdate>20210301</creationdate><title>Preparation, biodistribution and dosimetry study of Tc-99m labeled N-doped graphene quantum dot nanoparticles as a multimodular radiolabeling agent</title><author>Gharepapagh, Esmaeil ; Fakhari, Ashraf ; Firuzyar, Tahereh ; Shomali, Ashkan ; Azimi, Farzaneh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-a06743735a8fcdd0fa909a5c447f264fcd4d6b9dcbc80b5187c55ef26f8fa183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chelation</topic><topic>Dosimeters</topic><topic>Dosimetry</topic><topic>Graphene</topic><topic>Kidneys</topic><topic>Nanoparticles</topic><topic>Organs</topic><topic>Ovaries</topic><topic>Purity</topic><topic>Quantum dots</topic><topic>Radiation dosage</topic><topic>Radiochemistry</topic><topic>Radiolabelling</topic><topic>Solubility</topic><topic>Spleen</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gharepapagh, Esmaeil</creatorcontrib><creatorcontrib>Fakhari, Ashraf</creatorcontrib><creatorcontrib>Firuzyar, Tahereh</creatorcontrib><creatorcontrib>Shomali, Ashkan</creatorcontrib><creatorcontrib>Azimi, Farzaneh</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Illustrata: Natural Sciences</collection><collection>Materials Research Database</collection><collection>ProQuest Illustrata: Technology Collection</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gharepapagh, Esmaeil</au><au>Fakhari, Ashraf</au><au>Firuzyar, Tahereh</au><au>Shomali, Ashkan</au><au>Azimi, Farzaneh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation, biodistribution and dosimetry study of Tc-99m labeled N-doped graphene quantum dot nanoparticles as a multimodular radiolabeling agent</atitle><jtitle>New journal of chemistry</jtitle><date>2021-03-01</date><risdate>2021</risdate><volume>45</volume><issue>8</issue><spage>399</spage><epage>3919</epage><pages>399-3919</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>A new Tc-99m N-doped graphene quantum dot
99m
Tc-(N-GQD) moiety was developed as a radiolabeling agent for molecules lacking chelation or water solubility of ligands simultaneously. (N-GQDs) were synthesized and characterized with high purity (size range = 5-10 nm). After radiolabeling, ITLC demonstrated that the
99m
Tc-(N-GQDs) were prepared with high radiochemical purity (RCP ≥ 95%). Filtration of
99m
Tc-(N-GQDs) with a 0.1 μm filter proved that 77.38% of the particles were less than 0.1 μm.
99m
Tc-(N-GQDs) were injected into healthy Wistar rats for biodistribution studies. Results showed that
99m
Tc-(N-GQDs) were eliminated by the kidneys, and accumulated in the spleen due to the particle size of
99m
Tc-(N-GQDs). The ovaries and uterus showed a greater concentration of
99m
Tc-(N-GQDs) within 2 h after injection compared with other organs. Dosimetry studies were done to find out the effective radiation dose of each organ, and introduced the kidneys as critical organs. This research has demonstrated the profound feasible production of
99m
Tc-(N-GQDs) for possible radiolabeling of molecules with chelation limitations and poor water solubility.
Preparation, dosimetry and biodistribution study of
99m
Tc-(N-GQDs) as multipurpose nanoparticles.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d0nj04762g</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1732-5544</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1144-0546 |
| ispartof | New journal of chemistry, 2021-03, Vol.45 (8), p.399-3919 |
| issn | 1144-0546 1369-9261 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D0NJ04762G |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Chelation Dosimeters Dosimetry Graphene Kidneys Nanoparticles Organs Ovaries Purity Quantum dots Radiation dosage Radiochemistry Radiolabelling Solubility Spleen Uterus |
| title | Preparation, biodistribution and dosimetry study of Tc-99m labeled N-doped graphene quantum dot nanoparticles as a multimodular radiolabeling agent |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T17%3A23%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preparation,%20biodistribution%20and%20dosimetry%20study%20of%20Tc-99m%20labeled%20N-doped%20graphene%20quantum%20dot%20nanoparticles%20as%20a%20multimodular%20radiolabeling%20agent&rft.jtitle=New%20journal%20of%20chemistry&rft.au=Gharepapagh,%20Esmaeil&rft.date=2021-03-01&rft.volume=45&rft.issue=8&rft.spage=399&rft.epage=3919&rft.pages=399-3919&rft.issn=1144-0546&rft.eissn=1369-9261&rft_id=info:doi/10.1039/d0nj04762g&rft_dat=%3Cproquest_cross%3E2494165363%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2494165363&rft_id=info:pmid/&rfr_iscdi=true |