Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial
Background and aims : We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension. Methods and results : Forty women with arterial hypertension, 20-50 years, were assigned to two groups in this r...
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| creator | Romão da Silva, Larissa de Fátima de Oliveira, Yohanna de Souza, Evandro Leite de Luna Freire, Micaelle Oliveira Braga, Valdir de Andrade Magnani, Marciane de Brito Alves, José Luiz |
| description | Background and aims
: We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension.
Methods and results
: Forty women with arterial hypertension, 20-50 years, were assigned to two groups in this randomized, triple-blind, placebo-controlled clinical trial. Patients in the probiotic group received a daily sachet containing
Lactobacillus para casei
LPC-37,
Lactobacillus rhamnosus
HN001,
Lactobacillus acidophilus
NCFM, and
Bifidobacterium lactis
HN019 (10
9
CFU of each strain) for 8 weeks. Patients in the placebo group received identical sachets with polydextrose (1 g day
−1
, for 8 weeks). Anthropometric, BP, electrocardiogram, biochemical measurements, fecal microbiota composition, and glucose hydrogen breath test were assessed at baseline and after 8 weeks intervention. Anthropometric variables (weight, BMI, and waist circumference) were similar between the two groups (
p
> 0.05). Probiotic supplementation significantly reduced fasting glucose (change −10.3 mg dL
−1
,
p
< 0.05) and cholesterol levels (change −23.6 mg dL
−1
,
p
< 0.05), and increased the HDL-cholesterol (change 6.5 mg dL
−1
,
p
< 0.05) compared with the baseline condition. Probiotic supplementation lowered, although without statistical significance, systolic BP by about 5 mmHg and diastolic BP by about 2 mmHg in hypertensive women. Lastly, probiotic administration reduced the low frequency (LF) oscillation and LF/high frequency (HF) ratio (
p
< 0.05) in the frequency domain of heart rate variability, suggesting an improvement in autonomic modulation.
Conclusion
: Probiotic therapy for 8 weeks reduced fasting glucose levels, and improved the lipid profile and autonomic modulation in hypertensive women.
We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension. |
| doi_str_mv | 10.1039/d0fo01661f |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_D0FO01661F</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2430980728</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-84cbc97890814078bf89cb32f828e6ea3465d70533bf35b7bedc680d6ee50aff3</originalsourceid><addsrcrecordid>eNp90U9rFTEQAPBFLLa0vXhXIl5EuprdZLOJN6l9VSj0ouBtyZ8JTckma5JVnp_Gj2qer63gwVySYX4zJJmmedrhNx0m4q3BNuKOsc4-ao56TPuWDfjr4_szFeywOc35FtdFhOCCP2kOST8OjFFy1Py6sBZ0yShatKSoXCxOo3IDSS5bFAPSMhkX2xmKVNHX3CKTrBGkjGQwSK4lhjjXxBzN6mVxtcgFdLNdIBUI2X0H9CPOEN4hiVItqfgnmDNUkls8tMq7UKPFSw0qtjqGkqL3YHZA-pPmwEqf4fRuP26-bC4-n39sr64vP52_v2o1xbS0nGqlxcgF5h3FI1eWC61Ib3nPgYEklA1mxAMhypJBjQqMZhwbBjBgaS05bl7t-9Zf-LZCLtPssgbvZYC45qmnBAuOx55X-vIfehvXFOrtdmroRj7gvqrXe6VTzDmBnZbkZpm2U4en3eimD3hz_Wd0m4qf37Vc1Qzmgd4PqoIXe5Cyfsj-nf20mN0Tnv3PkN-7TKxH</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2435178502</pqid></control><display><type>article</type><title>Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><creator>Romão da Silva, Larissa de Fátima ; de Oliveira, Yohanna ; de Souza, Evandro Leite ; de Luna Freire, Micaelle Oliveira ; Braga, Valdir de Andrade ; Magnani, Marciane ; de Brito Alves, José Luiz</creator><creatorcontrib>Romão da Silva, Larissa de Fátima ; de Oliveira, Yohanna ; de Souza, Evandro Leite ; de Luna Freire, Micaelle Oliveira ; Braga, Valdir de Andrade ; Magnani, Marciane ; de Brito Alves, José Luiz</creatorcontrib><description>Background and aims
: We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension.
Methods and results
: Forty women with arterial hypertension, 20-50 years, were assigned to two groups in this randomized, triple-blind, placebo-controlled clinical trial. Patients in the probiotic group received a daily sachet containing
Lactobacillus para casei
LPC-37,
Lactobacillus rhamnosus
HN001,
Lactobacillus acidophilus
NCFM, and
Bifidobacterium lactis
HN019 (10
9
CFU of each strain) for 8 weeks. Patients in the placebo group received identical sachets with polydextrose (1 g day
−1
, for 8 weeks). Anthropometric, BP, electrocardiogram, biochemical measurements, fecal microbiota composition, and glucose hydrogen breath test were assessed at baseline and after 8 weeks intervention. Anthropometric variables (weight, BMI, and waist circumference) were similar between the two groups (
p
> 0.05). Probiotic supplementation significantly reduced fasting glucose (change −10.3 mg dL
−1
,
p
< 0.05) and cholesterol levels (change −23.6 mg dL
−1
,
p
< 0.05), and increased the HDL-cholesterol (change 6.5 mg dL
−1
,
p
< 0.05) compared with the baseline condition. Probiotic supplementation lowered, although without statistical significance, systolic BP by about 5 mmHg and diastolic BP by about 2 mmHg in hypertensive women. Lastly, probiotic administration reduced the low frequency (LF) oscillation and LF/high frequency (HF) ratio (
p
< 0.05) in the frequency domain of heart rate variability, suggesting an improvement in autonomic modulation.
Conclusion
: Probiotic therapy for 8 weeks reduced fasting glucose levels, and improved the lipid profile and autonomic modulation in hypertensive women.
We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d0fo01661f</identifier><identifier>PMID: 32756643</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Adult ; Anthropometry ; Autonomic nervous system ; Bifidobacterium - metabolism ; Bifidobacterium animalis ; Biomarkers - blood ; Blood Glucose - metabolism ; Blood Pressure ; C-Reactive Protein - metabolism ; Cardiovascular Diseases - microbiology ; Cardiovascular Diseases - therapy ; Cholesterol ; Cholesterol - blood ; Clinical trials ; Creatinine - blood ; EKG ; Electrocardiography ; Exercise ; Fasting ; Fecal microflora ; Feces - microbiology ; Female ; Glucose ; Heart Rate ; High density lipoprotein ; Humans ; Hypertension ; Hypertension - microbiology ; Hypertension - therapy ; Laboratory testing ; Lactobacilli ; Lactobacillus acidophilus - metabolism ; Lactobacillus casei - metabolism ; Lactobacillus rhamnosus - metabolism ; Lipids ; Mathematical analysis ; Metabolic Syndrome - microbiology ; Metabolic Syndrome - therapy ; Microbiota ; Middle Aged ; Modulation ; Nutrition Assessment ; Polydextrose ; Probiotics ; Probiotics - administration & dosage ; Randomization ; Supplements ; Therapy ; Triglycerides - blood ; Urea - blood ; Waist Circumference ; Young Adult</subject><ispartof>Food & function, 2020-08, Vol.11 (8), p.7152-7163</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-84cbc97890814078bf89cb32f828e6ea3465d70533bf35b7bedc680d6ee50aff3</citedby><cites>FETCH-LOGICAL-c404t-84cbc97890814078bf89cb32f828e6ea3465d70533bf35b7bedc680d6ee50aff3</cites><orcidid>0000-0003-4696-3809 ; 0000-0002-7771-0479</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32756643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romão da Silva, Larissa de Fátima</creatorcontrib><creatorcontrib>de Oliveira, Yohanna</creatorcontrib><creatorcontrib>de Souza, Evandro Leite</creatorcontrib><creatorcontrib>de Luna Freire, Micaelle Oliveira</creatorcontrib><creatorcontrib>Braga, Valdir de Andrade</creatorcontrib><creatorcontrib>Magnani, Marciane</creatorcontrib><creatorcontrib>de Brito Alves, José Luiz</creatorcontrib><title>Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>Background and aims
: We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension.
Methods and results
: Forty women with arterial hypertension, 20-50 years, were assigned to two groups in this randomized, triple-blind, placebo-controlled clinical trial. Patients in the probiotic group received a daily sachet containing
Lactobacillus para casei
LPC-37,
Lactobacillus rhamnosus
HN001,
Lactobacillus acidophilus
NCFM, and
Bifidobacterium lactis
HN019 (10
9
CFU of each strain) for 8 weeks. Patients in the placebo group received identical sachets with polydextrose (1 g day
−1
, for 8 weeks). Anthropometric, BP, electrocardiogram, biochemical measurements, fecal microbiota composition, and glucose hydrogen breath test were assessed at baseline and after 8 weeks intervention. Anthropometric variables (weight, BMI, and waist circumference) were similar between the two groups (
p
> 0.05). Probiotic supplementation significantly reduced fasting glucose (change −10.3 mg dL
−1
,
p
< 0.05) and cholesterol levels (change −23.6 mg dL
−1
,
p
< 0.05), and increased the HDL-cholesterol (change 6.5 mg dL
−1
,
p
< 0.05) compared with the baseline condition. Probiotic supplementation lowered, although without statistical significance, systolic BP by about 5 mmHg and diastolic BP by about 2 mmHg in hypertensive women. Lastly, probiotic administration reduced the low frequency (LF) oscillation and LF/high frequency (HF) ratio (
p
< 0.05) in the frequency domain of heart rate variability, suggesting an improvement in autonomic modulation.
Conclusion
: Probiotic therapy for 8 weeks reduced fasting glucose levels, and improved the lipid profile and autonomic modulation in hypertensive women.
We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension.</description><subject>Adult</subject><subject>Anthropometry</subject><subject>Autonomic nervous system</subject><subject>Bifidobacterium - metabolism</subject><subject>Bifidobacterium animalis</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular Diseases - microbiology</subject><subject>Cardiovascular Diseases - therapy</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Clinical trials</subject><subject>Creatinine - blood</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Exercise</subject><subject>Fasting</subject><subject>Fecal microflora</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Glucose</subject><subject>Heart Rate</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - microbiology</subject><subject>Hypertension - therapy</subject><subject>Laboratory testing</subject><subject>Lactobacilli</subject><subject>Lactobacillus acidophilus - metabolism</subject><subject>Lactobacillus casei - metabolism</subject><subject>Lactobacillus rhamnosus - metabolism</subject><subject>Lipids</subject><subject>Mathematical analysis</subject><subject>Metabolic Syndrome - microbiology</subject><subject>Metabolic Syndrome - therapy</subject><subject>Microbiota</subject><subject>Middle Aged</subject><subject>Modulation</subject><subject>Nutrition Assessment</subject><subject>Polydextrose</subject><subject>Probiotics</subject><subject>Probiotics - administration & dosage</subject><subject>Randomization</subject><subject>Supplements</subject><subject>Therapy</subject><subject>Triglycerides - blood</subject><subject>Urea - blood</subject><subject>Waist Circumference</subject><subject>Young Adult</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U9rFTEQAPBFLLa0vXhXIl5EuprdZLOJN6l9VSj0ouBtyZ8JTckma5JVnp_Gj2qer63gwVySYX4zJJmmedrhNx0m4q3BNuKOsc4-ao56TPuWDfjr4_szFeywOc35FtdFhOCCP2kOST8OjFFy1Py6sBZ0yShatKSoXCxOo3IDSS5bFAPSMhkX2xmKVNHX3CKTrBGkjGQwSK4lhjjXxBzN6mVxtcgFdLNdIBUI2X0H9CPOEN4hiVItqfgnmDNUkls8tMq7UKPFSw0qtjqGkqL3YHZA-pPmwEqf4fRuP26-bC4-n39sr64vP52_v2o1xbS0nGqlxcgF5h3FI1eWC61Ib3nPgYEklA1mxAMhypJBjQqMZhwbBjBgaS05bl7t-9Zf-LZCLtPssgbvZYC45qmnBAuOx55X-vIfehvXFOrtdmroRj7gvqrXe6VTzDmBnZbkZpm2U4en3eimD3hz_Wd0m4qf37Vc1Qzmgd4PqoIXe5Cyfsj-nf20mN0Tnv3PkN-7TKxH</recordid><startdate>20200819</startdate><enddate>20200819</enddate><creator>Romão da Silva, Larissa de Fátima</creator><creator>de Oliveira, Yohanna</creator><creator>de Souza, Evandro Leite</creator><creator>de Luna Freire, Micaelle Oliveira</creator><creator>Braga, Valdir de Andrade</creator><creator>Magnani, Marciane</creator><creator>de Brito Alves, José Luiz</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4696-3809</orcidid><orcidid>https://orcid.org/0000-0002-7771-0479</orcidid></search><sort><creationdate>20200819</creationdate><title>Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial</title><author>Romão da Silva, Larissa de Fátima ; de Oliveira, Yohanna ; de Souza, Evandro Leite ; de Luna Freire, Micaelle Oliveira ; Braga, Valdir de Andrade ; Magnani, Marciane ; de Brito Alves, José Luiz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-84cbc97890814078bf89cb32f828e6ea3465d70533bf35b7bedc680d6ee50aff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Anthropometry</topic><topic>Autonomic nervous system</topic><topic>Bifidobacterium - metabolism</topic><topic>Bifidobacterium animalis</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular Diseases - microbiology</topic><topic>Cardiovascular Diseases - therapy</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Clinical trials</topic><topic>Creatinine - blood</topic><topic>EKG</topic><topic>Electrocardiography</topic><topic>Exercise</topic><topic>Fasting</topic><topic>Fecal microflora</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Glucose</topic><topic>Heart Rate</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - microbiology</topic><topic>Hypertension - therapy</topic><topic>Laboratory testing</topic><topic>Lactobacilli</topic><topic>Lactobacillus acidophilus - metabolism</topic><topic>Lactobacillus casei - metabolism</topic><topic>Lactobacillus rhamnosus - metabolism</topic><topic>Lipids</topic><topic>Mathematical analysis</topic><topic>Metabolic Syndrome - microbiology</topic><topic>Metabolic Syndrome - therapy</topic><topic>Microbiota</topic><topic>Middle Aged</topic><topic>Modulation</topic><topic>Nutrition Assessment</topic><topic>Polydextrose</topic><topic>Probiotics</topic><topic>Probiotics - administration & dosage</topic><topic>Randomization</topic><topic>Supplements</topic><topic>Therapy</topic><topic>Triglycerides - blood</topic><topic>Urea - blood</topic><topic>Waist Circumference</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romão da Silva, Larissa de Fátima</creatorcontrib><creatorcontrib>de Oliveira, Yohanna</creatorcontrib><creatorcontrib>de Souza, Evandro Leite</creatorcontrib><creatorcontrib>de Luna Freire, Micaelle Oliveira</creatorcontrib><creatorcontrib>Braga, Valdir de Andrade</creatorcontrib><creatorcontrib>Magnani, Marciane</creatorcontrib><creatorcontrib>de Brito Alves, José Luiz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romão da Silva, Larissa de Fátima</au><au>de Oliveira, Yohanna</au><au>de Souza, Evandro Leite</au><au>de Luna Freire, Micaelle Oliveira</au><au>Braga, Valdir de Andrade</au><au>Magnani, Marciane</au><au>de Brito Alves, José Luiz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2020-08-19</date><risdate>2020</risdate><volume>11</volume><issue>8</issue><spage>7152</spage><epage>7163</epage><pages>7152-7163</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Background and aims
: We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension.
Methods and results
: Forty women with arterial hypertension, 20-50 years, were assigned to two groups in this randomized, triple-blind, placebo-controlled clinical trial. Patients in the probiotic group received a daily sachet containing
Lactobacillus para casei
LPC-37,
Lactobacillus rhamnosus
HN001,
Lactobacillus acidophilus
NCFM, and
Bifidobacterium lactis
HN019 (10
9
CFU of each strain) for 8 weeks. Patients in the placebo group received identical sachets with polydextrose (1 g day
−1
, for 8 weeks). Anthropometric, BP, electrocardiogram, biochemical measurements, fecal microbiota composition, and glucose hydrogen breath test were assessed at baseline and after 8 weeks intervention. Anthropometric variables (weight, BMI, and waist circumference) were similar between the two groups (
p
> 0.05). Probiotic supplementation significantly reduced fasting glucose (change −10.3 mg dL
−1
,
p
< 0.05) and cholesterol levels (change −23.6 mg dL
−1
,
p
< 0.05), and increased the HDL-cholesterol (change 6.5 mg dL
−1
,
p
< 0.05) compared with the baseline condition. Probiotic supplementation lowered, although without statistical significance, systolic BP by about 5 mmHg and diastolic BP by about 2 mmHg in hypertensive women. Lastly, probiotic administration reduced the low frequency (LF) oscillation and LF/high frequency (HF) ratio (
p
< 0.05) in the frequency domain of heart rate variability, suggesting an improvement in autonomic modulation.
Conclusion
: Probiotic therapy for 8 weeks reduced fasting glucose levels, and improved the lipid profile and autonomic modulation in hypertensive women.
We assessed the effects of probiotic therapy for 8 weeks on cardiometabolic variables and autonomic function in women medically diagnosed with arterial hypertension.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32756643</pmid><doi>10.1039/d0fo01661f</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4696-3809</orcidid><orcidid>https://orcid.org/0000-0002-7771-0479</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2042-6496 |
| ispartof | Food & function, 2020-08, Vol.11 (8), p.7152-7163 |
| issn | 2042-6496 2042-650X |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D0FO01661F |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Adult Anthropometry Autonomic nervous system Bifidobacterium - metabolism Bifidobacterium animalis Biomarkers - blood Blood Glucose - metabolism Blood Pressure C-Reactive Protein - metabolism Cardiovascular Diseases - microbiology Cardiovascular Diseases - therapy Cholesterol Cholesterol - blood Clinical trials Creatinine - blood EKG Electrocardiography Exercise Fasting Fecal microflora Feces - microbiology Female Glucose Heart Rate High density lipoprotein Humans Hypertension Hypertension - microbiology Hypertension - therapy Laboratory testing Lactobacilli Lactobacillus acidophilus - metabolism Lactobacillus casei - metabolism Lactobacillus rhamnosus - metabolism Lipids Mathematical analysis Metabolic Syndrome - microbiology Metabolic Syndrome - therapy Microbiota Middle Aged Modulation Nutrition Assessment Polydextrose Probiotics Probiotics - administration & dosage Randomization Supplements Therapy Triglycerides - blood Urea - blood Waist Circumference Young Adult |
| title | Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial |
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