An efficient and easily-accessible ligand for Cu()-catalyzed azide-alkyne cycloaddition bioconjugation
A novel ligand ( 6 ) for copper-catalyzed azide-alkyne cycloaddition (CuAAC) in bioconjugation has been developed. Both in vitro and in vivo experiments indicate that 6 is more efficient and less cytotoxic than the canonical CuAAC ligands. Besides, 6 is easily accessible and can be prepared at gram...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-11, Vol.56 (92), p.1441-1443 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Guo, Yuan-Yang Zhang, Bo Wang, Luying Huang, Shenlong Wang, Shilei You, Yanbo Zhu, Gongming Zhu, Anlian Geng, Mingwei Li, Lingjun |
| description | A novel ligand (
6
) for copper-catalyzed azide-alkyne cycloaddition (CuAAC) in bioconjugation has been developed. Both
in vitro
and
in vivo
experiments indicate that
6
is more efficient and less cytotoxic than the canonical CuAAC ligands. Besides,
6
is easily accessible and can be prepared at gram scale. Our study reveals that
6
might be an ideal CuAAC ligand for bioconjugations.
A novel ligand (6) for copper-catalyzed azide-alkyne cycloaddition (CuAAC) in bioconjugation has been developed. |
| doi_str_mv | 10.1039/d0cc06348g |
| format | Article |
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6
) for copper-catalyzed azide-alkyne cycloaddition (CuAAC) in bioconjugation has been developed. Both
in vitro
and
in vivo
experiments indicate that
6
is more efficient and less cytotoxic than the canonical CuAAC ligands. Besides,
6
is easily accessible and can be prepared at gram scale. Our study reveals that
6
might be an ideal CuAAC ligand for bioconjugations.
A novel ligand (6) for copper-catalyzed azide-alkyne cycloaddition (CuAAC) in bioconjugation has been developed.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d0cc06348g</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Accessibility ; Alkynes ; Copper ; Cycloaddition ; Ligands</subject><ispartof>Chemical communications (Cambridge, England), 2020-11, Vol.56 (92), p.1441-1443</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c314t-b2eaf6314e1182523155cc81bddcc658695ca8e37a3a82caa99d8800d3aa10c3</citedby><cites>FETCH-LOGICAL-c314t-b2eaf6314e1182523155cc81bddcc658695ca8e37a3a82caa99d8800d3aa10c3</cites><orcidid>0000-0002-4722-3637 ; 0000-0003-2034-7792</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Guo, Yuan-Yang</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Wang, Luying</creatorcontrib><creatorcontrib>Huang, Shenlong</creatorcontrib><creatorcontrib>Wang, Shilei</creatorcontrib><creatorcontrib>You, Yanbo</creatorcontrib><creatorcontrib>Zhu, Gongming</creatorcontrib><creatorcontrib>Zhu, Anlian</creatorcontrib><creatorcontrib>Geng, Mingwei</creatorcontrib><creatorcontrib>Li, Lingjun</creatorcontrib><title>An efficient and easily-accessible ligand for Cu()-catalyzed azide-alkyne cycloaddition bioconjugation</title><title>Chemical communications (Cambridge, England)</title><description>A novel ligand (
6
) for copper-catalyzed azide-alkyne cycloaddition (CuAAC) in bioconjugation has been developed. Both
in vitro
and
in vivo
experiments indicate that
6
is more efficient and less cytotoxic than the canonical CuAAC ligands. Besides,
6
is easily accessible and can be prepared at gram scale. Our study reveals that
6
might be an ideal CuAAC ligand for bioconjugations.
A novel ligand (6) for copper-catalyzed azide-alkyne cycloaddition (CuAAC) in bioconjugation has been developed.</description><subject>Accessibility</subject><subject>Alkynes</subject><subject>Copper</subject><subject>Cycloaddition</subject><subject>Ligands</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpd0UFLwzAUAOAiCs7pxbsQ8DKFatI0bXocVacw8LKDt_L6ko7MrJlNe-h-ve0mCuby3uN9PB4vQXDN6AOjPHtUFJEmPJbrk2DCeBKHIpYfp2MusjDlsTgPLrzf0OExISdBNa-JriqDRtctgVoRDd7YPgRE7b0prSbWrMdG5RqSd7O7EKEF2--1IrA3SodgP_taE-zROlDKtMbVpDQOXb3p1jCWl8FZBdbrq584DVYvz6v8NVy-L97y-TJEzuI2LCMNVTKkmjEZiYgzIRAlK5VCTIRMMoEgNU-Bg4wQIMuUlJQqDsAo8mkwO47dNe6r074ttsajthZq7TpfRLFIozRJRTzQ239047qmHpYbVBLJLOUHdX9U2DjvG10Vu8ZsoekLRovx4sUTzfPDxRcDvjnixuOv-_sR_g28y324</recordid><startdate>20201119</startdate><enddate>20201119</enddate><creator>Guo, Yuan-Yang</creator><creator>Zhang, Bo</creator><creator>Wang, Luying</creator><creator>Huang, Shenlong</creator><creator>Wang, Shilei</creator><creator>You, Yanbo</creator><creator>Zhu, Gongming</creator><creator>Zhu, Anlian</creator><creator>Geng, Mingwei</creator><creator>Li, Lingjun</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4722-3637</orcidid><orcidid>https://orcid.org/0000-0003-2034-7792</orcidid></search><sort><creationdate>20201119</creationdate><title>An efficient and easily-accessible ligand for Cu()-catalyzed azide-alkyne cycloaddition bioconjugation</title><author>Guo, Yuan-Yang ; Zhang, Bo ; Wang, Luying ; Huang, Shenlong ; Wang, Shilei ; You, Yanbo ; Zhu, Gongming ; Zhu, Anlian ; Geng, Mingwei ; Li, Lingjun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c314t-b2eaf6314e1182523155cc81bddcc658695ca8e37a3a82caa99d8800d3aa10c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Accessibility</topic><topic>Alkynes</topic><topic>Copper</topic><topic>Cycloaddition</topic><topic>Ligands</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Yuan-Yang</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Wang, Luying</creatorcontrib><creatorcontrib>Huang, Shenlong</creatorcontrib><creatorcontrib>Wang, Shilei</creatorcontrib><creatorcontrib>You, Yanbo</creatorcontrib><creatorcontrib>Zhu, Gongming</creatorcontrib><creatorcontrib>Zhu, Anlian</creatorcontrib><creatorcontrib>Geng, Mingwei</creatorcontrib><creatorcontrib>Li, Lingjun</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Yuan-Yang</au><au>Zhang, Bo</au><au>Wang, Luying</au><au>Huang, Shenlong</au><au>Wang, Shilei</au><au>You, Yanbo</au><au>Zhu, Gongming</au><au>Zhu, Anlian</au><au>Geng, Mingwei</au><au>Li, Lingjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An efficient and easily-accessible ligand for Cu()-catalyzed azide-alkyne cycloaddition bioconjugation</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><date>2020-11-19</date><risdate>2020</risdate><volume>56</volume><issue>92</issue><spage>1441</spage><epage>1443</epage><pages>1441-1443</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>A novel ligand (
6
) for copper-catalyzed azide-alkyne cycloaddition (CuAAC) in bioconjugation has been developed. Both
in vitro
and
in vivo
experiments indicate that
6
is more efficient and less cytotoxic than the canonical CuAAC ligands. Besides,
6
is easily accessible and can be prepared at gram scale. Our study reveals that
6
might be an ideal CuAAC ligand for bioconjugations.
A novel ligand (6) for copper-catalyzed azide-alkyne cycloaddition (CuAAC) in bioconjugation has been developed.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d0cc06348g</doi><tpages>3</tpages><orcidid>https://orcid.org/0000-0002-4722-3637</orcidid><orcidid>https://orcid.org/0000-0003-2034-7792</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2020-11, Vol.56 (92), p.1441-1443 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D0CC06348G |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Accessibility Alkynes Copper Cycloaddition Ligands |
| title | An efficient and easily-accessible ligand for Cu()-catalyzed azide-alkyne cycloaddition bioconjugation |
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