C-Terminal lactamization of peptides

Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or -lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides. New solid-phase based methods have allowed efficient synthesis of natural products and novel peptide hormone derivatives with a C-terminal lactam.