Enhanced nuclear accumulation of pyrrole-imidazole polyamides by incorporation of the tri-arginine vector
The tri-arginine moiety enhanced nuclear accumulation of a 12-ring pyrrole-imidazole polyamide (PIP) without compromising sequence-selectivity and achieved efficient repression of SOX2-downstream genes and HER2 transcription in live cells. This simple vector expands the application of long PIPs in l...
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Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-10, Vol.56 (82), p.12371-12374 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The tri-arginine moiety enhanced nuclear accumulation of a 12-ring pyrrole-imidazole polyamide (PIP) without compromising sequence-selectivity and achieved efficient repression of SOX2-downstream genes and
HER2
transcription in live cells. This simple vector expands the application of long PIPs in live cells by overcoming the compound delivery problems associated with them.
The tri-arginine vector enhanced cellular uptake of a 12-ring pyrrole-imidazole polyamide and significantly reduced the concentration of compound required for transcriptional repression of
SOX2
. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/d0cc05158f |