Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?
Deamidated amyloid proteins have been shown to accelerate fibril formation. Herein, the results show the inhibition performance and the interaction site between site-specific inhibitor and amyloid protein are significantly influenced by deamidation; while the inhibition mechanism of non-site specifi...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-08, Vol.56 (68), p.9787-979 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Lam, Yuko P. Y Chiu, Cookson K. C Wootton, Christopher A Hands-Portman, Ian Li, Meng Barrow, Mark P O'Connor, Peter B |
| description | Deamidated amyloid proteins have been shown to accelerate fibril formation. Herein, the results show the inhibition performance and the interaction site between site-specific inhibitor and amyloid protein are significantly influenced by deamidation; while the inhibition mechanism of non-site specific inhibitor shows no significant disruption caused by amyloid protein deamidation.
A diagram to show the differences between wild-type and deamidated hIAPPs interaction with site specific and non-specific inhibitors. |
| doi_str_mv | 10.1039/d0cc03548c |
| format | Article |
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Herein, the results show the inhibition performance and the interaction site between site-specific inhibitor and amyloid protein are significantly influenced by deamidation; while the inhibition mechanism of non-site specific inhibitor shows no significant disruption caused by amyloid protein deamidation.
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Amyloid - chemistry Amyloid - metabolism Catechin - analogs & derivatives Catechin - chemistry Catechin - metabolism Catechin - pharmacology Humans Inhibitors Islet Amyloid Polypeptide - chemistry Islet Amyloid Polypeptide - metabolism Microscopy, Electron, Transmission Protein Aggregates - drug effects Proteins Spectrometry, Fluorescence |
| title | Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation? |
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