Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response
The surface chemistry of cellulose nanocrystals was engineered to show variable sulfation degrees, which was exploited to modulate platelet lysate-derived biomolecule sequestration and presentation. The protein coronas developed on CNC surfaces were characterized and it was demonstrated how they pro...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-06, Vol.56 (5), p.6882-6885 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Mendes, Bárbara B Gómez-Florit, Manuel Osório, Hugo Vilaça, Adriana Domingues, Rui M. A Reis, Rui L Gomes, Manuela E |
| description | The surface chemistry of cellulose nanocrystals was engineered to show variable sulfation degrees, which was exploited to modulate platelet lysate-derived biomolecule sequestration and presentation. The protein coronas developed on CNC surfaces were characterized and it was demonstrated how they promote different signaling effects on human adipose-derived stem cell behavior.
Cellulose nanocrystals can bind different patterns of platelet lysate-derived protein in a surface sulfation dependent manner. The potential to direct stem cell fate by solid-phase presentation of defined protein coronas is demonstrated. |
| doi_str_mv | 10.1039/d0cc01850c |
| format | Article |
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Cellulose nanocrystals can bind different patterns of platelet lysate-derived protein in a surface sulfation dependent manner. The potential to direct stem cell fate by solid-phase presentation of defined protein coronas is demonstrated.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/d0cc01850c</identifier><identifier>PMID: 32435790</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Adipose Tissue - cytology ; Biomolecules ; Blood Platelets ; Cells, Cultured ; Cellulose ; Cellulose - administration & dosage ; Cellulose - chemistry ; Coronas ; Humans ; Hydrolysis ; Nanocrystals ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Protein Corona - chemistry ; Stem cells ; Stem Cells - drug effects ; Sulfation ; Sulfuric Acids - chemistry ; Surface Properties</subject><ispartof>Chemical communications (Cambridge, England), 2020-06, Vol.56 (5), p.6882-6885</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-f2000c4bd7e7457f2cac41d4cc2278fce822f4028c5e8216017802ad50b0df6d3</citedby><cites>FETCH-LOGICAL-c424t-f2000c4bd7e7457f2cac41d4cc2278fce822f4028c5e8216017802ad50b0df6d3</cites><orcidid>0000-0001-7758-1251 ; 0000-0002-4295-6129 ; 0000-0002-3654-9906 ; 0000-0002-2036-6291 ; 0000-0001-8630-1119</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32435790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mendes, Bárbara B</creatorcontrib><creatorcontrib>Gómez-Florit, Manuel</creatorcontrib><creatorcontrib>Osório, Hugo</creatorcontrib><creatorcontrib>Vilaça, Adriana</creatorcontrib><creatorcontrib>Domingues, Rui M. A</creatorcontrib><creatorcontrib>Reis, Rui L</creatorcontrib><creatorcontrib>Gomes, Manuela E</creatorcontrib><title>Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>The surface chemistry of cellulose nanocrystals was engineered to show variable sulfation degrees, which was exploited to modulate platelet lysate-derived biomolecule sequestration and presentation. The protein coronas developed on CNC surfaces were characterized and it was demonstrated how they promote different signaling effects on human adipose-derived stem cell behavior.
Cellulose nanocrystals can bind different patterns of platelet lysate-derived protein in a surface sulfation dependent manner. The potential to direct stem cell fate by solid-phase presentation of defined protein coronas is demonstrated.</description><subject>Adipose Tissue - cytology</subject><subject>Biomolecules</subject><subject>Blood Platelets</subject><subject>Cells, Cultured</subject><subject>Cellulose</subject><subject>Cellulose - administration & dosage</subject><subject>Cellulose - chemistry</subject><subject>Coronas</subject><subject>Humans</subject><subject>Hydrolysis</subject><subject>Nanocrystals</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Protein Corona - chemistry</subject><subject>Stem cells</subject><subject>Stem Cells - drug effects</subject><subject>Sulfation</subject><subject>Sulfuric Acids - chemistry</subject><subject>Surface Properties</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtLxTAQhYMovjfulYg7oZqkyW3vUuoTBDcK7ko6mUglbWrSCvdX-JfN9frYmU0OnG9mMieEHHB2xlk-PzcMgPFSMVgj2zyfyUzJ8nl9qdU8K3KptshOjK8sHa7KTbKVC5mrYs62yUeFzk3OR6S97j2ERRy1i9Rb-q5DqxuHNE7O6rH1PTX4EhAjBd3TiG8TxhEDjQNCa1ugg9MjOhypW8SkMoOhfUdDm9Z33iFMLtWOnnbeTEuUpvKOQnoBDRgH30fcIxs2zcf973uXPF1fPVa32f3DzV11cZ-BFHLMrEi7gGxMgYVUhRWgQXIjAYQoSgtYCmElEyWoJPmM8aJkQhvFGmbszOS75GTVdwj-a4_61U-hTyNrIVNIophLnqjTFQXBxxjQ1kNoOx0WNWf1Mvv6klXVV_ZVgo--W05Nh-YX_Qk7AYcrIET4df8-L_nH__n1YGz-Cfiql6k</recordid><startdate>20200625</startdate><enddate>20200625</enddate><creator>Mendes, Bárbara B</creator><creator>Gómez-Florit, Manuel</creator><creator>Osório, Hugo</creator><creator>Vilaça, Adriana</creator><creator>Domingues, Rui M. 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| ispartof | Chemical communications (Cambridge, England), 2020-06, Vol.56 (5), p.6882-6885 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Adipose Tissue - cytology Biomolecules Blood Platelets Cells, Cultured Cellulose Cellulose - administration & dosage Cellulose - chemistry Coronas Humans Hydrolysis Nanocrystals Nanoparticles - administration & dosage Nanoparticles - chemistry Protein Corona - chemistry Stem cells Stem Cells - drug effects Sulfation Sulfuric Acids - chemistry Surface Properties |
| title | Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response |
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