Engineering red-emitting multi-functional nanocapsules for magnetic tumour targeting and imaging
In this work we describe the formulation and characterisation of red-emitting polymeric nanocapsules (NCs) incorporating superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic tumour targeting. The self-fluorescent oligomers were synthesised and chemically conjugated to PLGA which was conf...
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| Veröffentlicht in: | Biomaterials science 2020-05, Vol.8 (9), p.259-2599 |
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| creator | Wang, Julie Tzu-Wen Martino, Umberto Khan, Rehan Bazzar, Maasoomeh Southern, Paul Tuncel, Dönü Al-Jamal, Khuloud T |
| description | In this work we describe the formulation and characterisation of red-emitting polymeric nanocapsules (NCs) incorporating superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic tumour targeting. The self-fluorescent oligomers were synthesised and chemically conjugated to PLGA which was confirmed by NMR spectroscopy, FT-IR spectroscopy and mass spectrometry. Hydrophobic SPIONs were synthesised through thermal decomposition and their magnetic and heating properties were assessed by SQUID magnetometry and calorimetric measurements, respectively. Magnetic nanocapsules (m-NCs) were prepared by a single emulsification/solvent evaporation method. Their
in vitro
cytotoxicity was examined in CT26 colon cancer cells. The formulated fluorescent m-NCs showed good stability and biocompatibility both
in vitro
and
in vivo
in CT 26 colon cancer models. Following intravenous injection, accumulation of m-NCs in tumours was observed by optical imaging. A higher iron content in the tumours exposed to a magnetic field, compared to the contralateral tumours without magnetic exposure in the same animal, further confirmed the magnetic tumour targeting
in vivo
. The overall results show that the engineered red-emitting m-NCs have great potential as multifunctional nanocarriers for multi-model bioimaging and magnetic-targeted drug delivery.
Self-red-emitting magnetic PLGA-PEG nanocapsules for optical imaging and magnetic tumour targeting. |
| doi_str_mv | 10.1039/d0bm00314j |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1039_D0BM00314J</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2398499748</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-959f126721c49bf81539309046d48cff145871a47daf84b5dad40cce92fea55d3</originalsourceid><addsrcrecordid>eNp9kTtPwzAURi0EolXpwg4KYkMK2LFTxyOU8lIRC8zB8SNKlTjBj4F_j_ugbHjxvbrHV5-OAThF8BpBzG4krDoIMSKrAzDOIKEpKQg73NcYjsDUuRWMh1IGZ-gYjHCW4YIxOgafC1M3RinbmDqxSqaqa7xfN11ofZPqYIRvesPbxHDTCz640CqX6N4mHa-N8o1IfOj6YBPPba02b7mRSRPHsT4BR5q3Tk139wR8PCze50_p8u3xeX67TAVmzKcsZxplM5ohQVilC5RjhiGDZCZJIbRGJC8o4oRKrgtS5ZJLAoVQLNOK57nEE3C53TvY_iso58tVzBRzuzLDLCphNMqYgKstJWzvnFW6HGwMar9LBMu1z_Ie3r1ufL5E-Hy3MlSdknv0114ELraAdWI__fuQcpA6Mmf_MfgHjeyGTg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2398499748</pqid></control><display><type>article</type><title>Engineering red-emitting multi-functional nanocapsules for magnetic tumour targeting and imaging</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><creator>Wang, Julie Tzu-Wen ; Martino, Umberto ; Khan, Rehan ; Bazzar, Maasoomeh ; Southern, Paul ; Tuncel, Dönü ; Al-Jamal, Khuloud T</creator><creatorcontrib>Wang, Julie Tzu-Wen ; Martino, Umberto ; Khan, Rehan ; Bazzar, Maasoomeh ; Southern, Paul ; Tuncel, Dönü ; Al-Jamal, Khuloud T</creatorcontrib><description>In this work we describe the formulation and characterisation of red-emitting polymeric nanocapsules (NCs) incorporating superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic tumour targeting. The self-fluorescent oligomers were synthesised and chemically conjugated to PLGA which was confirmed by NMR spectroscopy, FT-IR spectroscopy and mass spectrometry. Hydrophobic SPIONs were synthesised through thermal decomposition and their magnetic and heating properties were assessed by SQUID magnetometry and calorimetric measurements, respectively. Magnetic nanocapsules (m-NCs) were prepared by a single emulsification/solvent evaporation method. Their
in vitro
cytotoxicity was examined in CT26 colon cancer cells. The formulated fluorescent m-NCs showed good stability and biocompatibility both
in vitro
and
in vivo
in CT 26 colon cancer models. Following intravenous injection, accumulation of m-NCs in tumours was observed by optical imaging. A higher iron content in the tumours exposed to a magnetic field, compared to the contralateral tumours without magnetic exposure in the same animal, further confirmed the magnetic tumour targeting
in vivo
. The overall results show that the engineered red-emitting m-NCs have great potential as multifunctional nanocarriers for multi-model bioimaging and magnetic-targeted drug delivery.
Self-red-emitting magnetic PLGA-PEG nanocapsules for optical imaging and magnetic tumour targeting.</description><identifier>ISSN: 2047-4830</identifier><identifier>EISSN: 2047-4849</identifier><identifier>DOI: 10.1039/d0bm00314j</identifier><identifier>PMID: 32238997</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Biocompatibility ; Cell Line, Tumor ; Colon ; Colorectal cancer ; Drug Delivery Systems ; Female ; Ferric Compounds - administration & dosage ; Ferric Compounds - pharmacokinetics ; Fluorescence ; Fluorescent Dyes - administration & dosage ; Fluorescent Dyes - pharmacokinetics ; Hyperthermia, Induced ; In vitro methods and tests ; Infrared spectroscopy ; Iron - metabolism ; Iron oxides ; Magnetic measurement ; Magnetic Phenomena ; Magnetic properties ; Mass spectrometry ; Medical imaging ; Mice, Inbred BALB C ; Nanocapsules - administration & dosage ; Nanoparticles ; Neoplasms - diagnostic imaging ; Neoplasms - metabolism ; Neoplasms - therapy ; NMR spectroscopy ; Oligomers ; Polyethylene Glycols - administration & dosage ; Polyethylene Glycols - pharmacokinetics ; Polyglactin 910 - administration & dosage ; Polyglactin 910 - pharmacokinetics ; Superconducting quantum interference devices ; Thermal decomposition ; Tissue Distribution ; Toxicity ; Tumors</subject><ispartof>Biomaterials science, 2020-05, Vol.8 (9), p.259-2599</ispartof><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-959f126721c49bf81539309046d48cff145871a47daf84b5dad40cce92fea55d3</citedby><cites>FETCH-LOGICAL-c399t-959f126721c49bf81539309046d48cff145871a47daf84b5dad40cce92fea55d3</cites><orcidid>0000-0001-7762-9200 ; 0000-0001-5165-2699 ; 0000-0001-5956-0123 ; 0000-0002-9771-7117</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32238997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Julie Tzu-Wen</creatorcontrib><creatorcontrib>Martino, Umberto</creatorcontrib><creatorcontrib>Khan, Rehan</creatorcontrib><creatorcontrib>Bazzar, Maasoomeh</creatorcontrib><creatorcontrib>Southern, Paul</creatorcontrib><creatorcontrib>Tuncel, Dönü</creatorcontrib><creatorcontrib>Al-Jamal, Khuloud T</creatorcontrib><title>Engineering red-emitting multi-functional nanocapsules for magnetic tumour targeting and imaging</title><title>Biomaterials science</title><addtitle>Biomater Sci</addtitle><description>In this work we describe the formulation and characterisation of red-emitting polymeric nanocapsules (NCs) incorporating superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic tumour targeting. The self-fluorescent oligomers were synthesised and chemically conjugated to PLGA which was confirmed by NMR spectroscopy, FT-IR spectroscopy and mass spectrometry. Hydrophobic SPIONs were synthesised through thermal decomposition and their magnetic and heating properties were assessed by SQUID magnetometry and calorimetric measurements, respectively. Magnetic nanocapsules (m-NCs) were prepared by a single emulsification/solvent evaporation method. Their
in vitro
cytotoxicity was examined in CT26 colon cancer cells. The formulated fluorescent m-NCs showed good stability and biocompatibility both
in vitro
and
in vivo
in CT 26 colon cancer models. Following intravenous injection, accumulation of m-NCs in tumours was observed by optical imaging. A higher iron content in the tumours exposed to a magnetic field, compared to the contralateral tumours without magnetic exposure in the same animal, further confirmed the magnetic tumour targeting
in vivo
. The overall results show that the engineered red-emitting m-NCs have great potential as multifunctional nanocarriers for multi-model bioimaging and magnetic-targeted drug delivery.
Self-red-emitting magnetic PLGA-PEG nanocapsules for optical imaging and magnetic tumour targeting.</description><subject>Animals</subject><subject>Biocompatibility</subject><subject>Cell Line, Tumor</subject><subject>Colon</subject><subject>Colorectal cancer</subject><subject>Drug Delivery Systems</subject><subject>Female</subject><subject>Ferric Compounds - administration & dosage</subject><subject>Ferric Compounds - pharmacokinetics</subject><subject>Fluorescence</subject><subject>Fluorescent Dyes - administration & dosage</subject><subject>Fluorescent Dyes - pharmacokinetics</subject><subject>Hyperthermia, Induced</subject><subject>In vitro methods and tests</subject><subject>Infrared spectroscopy</subject><subject>Iron - metabolism</subject><subject>Iron oxides</subject><subject>Magnetic measurement</subject><subject>Magnetic Phenomena</subject><subject>Magnetic properties</subject><subject>Mass spectrometry</subject><subject>Medical imaging</subject><subject>Mice, Inbred BALB C</subject><subject>Nanocapsules - administration & dosage</subject><subject>Nanoparticles</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - therapy</subject><subject>NMR spectroscopy</subject><subject>Oligomers</subject><subject>Polyethylene Glycols - administration & dosage</subject><subject>Polyethylene Glycols - pharmacokinetics</subject><subject>Polyglactin 910 - administration & dosage</subject><subject>Polyglactin 910 - pharmacokinetics</subject><subject>Superconducting quantum interference devices</subject><subject>Thermal decomposition</subject><subject>Tissue Distribution</subject><subject>Toxicity</subject><subject>Tumors</subject><issn>2047-4830</issn><issn>2047-4849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kTtPwzAURi0EolXpwg4KYkMK2LFTxyOU8lIRC8zB8SNKlTjBj4F_j_ugbHjxvbrHV5-OAThF8BpBzG4krDoIMSKrAzDOIKEpKQg73NcYjsDUuRWMh1IGZ-gYjHCW4YIxOgafC1M3RinbmDqxSqaqa7xfN11ofZPqYIRvesPbxHDTCz640CqX6N4mHa-N8o1IfOj6YBPPba02b7mRSRPHsT4BR5q3Tk139wR8PCze50_p8u3xeX67TAVmzKcsZxplM5ohQVilC5RjhiGDZCZJIbRGJC8o4oRKrgtS5ZJLAoVQLNOK57nEE3C53TvY_iso58tVzBRzuzLDLCphNMqYgKstJWzvnFW6HGwMar9LBMu1z_Ie3r1ufL5E-Hy3MlSdknv0114ELraAdWI__fuQcpA6Mmf_MfgHjeyGTg</recordid><startdate>20200506</startdate><enddate>20200506</enddate><creator>Wang, Julie Tzu-Wen</creator><creator>Martino, Umberto</creator><creator>Khan, Rehan</creator><creator>Bazzar, Maasoomeh</creator><creator>Southern, Paul</creator><creator>Tuncel, Dönü</creator><creator>Al-Jamal, Khuloud T</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0001-7762-9200</orcidid><orcidid>https://orcid.org/0000-0001-5165-2699</orcidid><orcidid>https://orcid.org/0000-0001-5956-0123</orcidid><orcidid>https://orcid.org/0000-0002-9771-7117</orcidid></search><sort><creationdate>20200506</creationdate><title>Engineering red-emitting multi-functional nanocapsules for magnetic tumour targeting and imaging</title><author>Wang, Julie Tzu-Wen ; Martino, Umberto ; Khan, Rehan ; Bazzar, Maasoomeh ; Southern, Paul ; Tuncel, Dönü ; Al-Jamal, Khuloud T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-959f126721c49bf81539309046d48cff145871a47daf84b5dad40cce92fea55d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Biocompatibility</topic><topic>Cell Line, Tumor</topic><topic>Colon</topic><topic>Colorectal cancer</topic><topic>Drug Delivery Systems</topic><topic>Female</topic><topic>Ferric Compounds - administration & dosage</topic><topic>Ferric Compounds - pharmacokinetics</topic><topic>Fluorescence</topic><topic>Fluorescent Dyes - administration & dosage</topic><topic>Fluorescent Dyes - pharmacokinetics</topic><topic>Hyperthermia, Induced</topic><topic>In vitro methods and tests</topic><topic>Infrared spectroscopy</topic><topic>Iron - metabolism</topic><topic>Iron oxides</topic><topic>Magnetic measurement</topic><topic>Magnetic Phenomena</topic><topic>Magnetic properties</topic><topic>Mass spectrometry</topic><topic>Medical imaging</topic><topic>Mice, Inbred BALB C</topic><topic>Nanocapsules - administration & dosage</topic><topic>Nanoparticles</topic><topic>Neoplasms - diagnostic imaging</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - therapy</topic><topic>NMR spectroscopy</topic><topic>Oligomers</topic><topic>Polyethylene Glycols - administration & dosage</topic><topic>Polyethylene Glycols - pharmacokinetics</topic><topic>Polyglactin 910 - administration & dosage</topic><topic>Polyglactin 910 - pharmacokinetics</topic><topic>Superconducting quantum interference devices</topic><topic>Thermal decomposition</topic><topic>Tissue Distribution</topic><topic>Toxicity</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Julie Tzu-Wen</creatorcontrib><creatorcontrib>Martino, Umberto</creatorcontrib><creatorcontrib>Khan, Rehan</creatorcontrib><creatorcontrib>Bazzar, Maasoomeh</creatorcontrib><creatorcontrib>Southern, Paul</creatorcontrib><creatorcontrib>Tuncel, Dönü</creatorcontrib><creatorcontrib>Al-Jamal, Khuloud T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Biomaterials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Julie Tzu-Wen</au><au>Martino, Umberto</au><au>Khan, Rehan</au><au>Bazzar, Maasoomeh</au><au>Southern, Paul</au><au>Tuncel, Dönü</au><au>Al-Jamal, Khuloud T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engineering red-emitting multi-functional nanocapsules for magnetic tumour targeting and imaging</atitle><jtitle>Biomaterials science</jtitle><addtitle>Biomater Sci</addtitle><date>2020-05-06</date><risdate>2020</risdate><volume>8</volume><issue>9</issue><spage>259</spage><epage>2599</epage><pages>259-2599</pages><issn>2047-4830</issn><eissn>2047-4849</eissn><abstract>In this work we describe the formulation and characterisation of red-emitting polymeric nanocapsules (NCs) incorporating superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic tumour targeting. The self-fluorescent oligomers were synthesised and chemically conjugated to PLGA which was confirmed by NMR spectroscopy, FT-IR spectroscopy and mass spectrometry. Hydrophobic SPIONs were synthesised through thermal decomposition and their magnetic and heating properties were assessed by SQUID magnetometry and calorimetric measurements, respectively. Magnetic nanocapsules (m-NCs) were prepared by a single emulsification/solvent evaporation method. Their
in vitro
cytotoxicity was examined in CT26 colon cancer cells. The formulated fluorescent m-NCs showed good stability and biocompatibility both
in vitro
and
in vivo
in CT 26 colon cancer models. Following intravenous injection, accumulation of m-NCs in tumours was observed by optical imaging. A higher iron content in the tumours exposed to a magnetic field, compared to the contralateral tumours without magnetic exposure in the same animal, further confirmed the magnetic tumour targeting
in vivo
. The overall results show that the engineered red-emitting m-NCs have great potential as multifunctional nanocarriers for multi-model bioimaging and magnetic-targeted drug delivery.
Self-red-emitting magnetic PLGA-PEG nanocapsules for optical imaging and magnetic tumour targeting.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>32238997</pmid><doi>10.1039/d0bm00314j</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7762-9200</orcidid><orcidid>https://orcid.org/0000-0001-5165-2699</orcidid><orcidid>https://orcid.org/0000-0001-5956-0123</orcidid><orcidid>https://orcid.org/0000-0002-9771-7117</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Biomaterials science, 2020-05, Vol.8 (9), p.259-2599 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Animals Biocompatibility Cell Line, Tumor Colon Colorectal cancer Drug Delivery Systems Female Ferric Compounds - administration & dosage Ferric Compounds - pharmacokinetics Fluorescence Fluorescent Dyes - administration & dosage Fluorescent Dyes - pharmacokinetics Hyperthermia, Induced In vitro methods and tests Infrared spectroscopy Iron - metabolism Iron oxides Magnetic measurement Magnetic Phenomena Magnetic properties Mass spectrometry Medical imaging Mice, Inbred BALB C Nanocapsules - administration & dosage Nanoparticles Neoplasms - diagnostic imaging Neoplasms - metabolism Neoplasms - therapy NMR spectroscopy Oligomers Polyethylene Glycols - administration & dosage Polyethylene Glycols - pharmacokinetics Polyglactin 910 - administration & dosage Polyglactin 910 - pharmacokinetics Superconducting quantum interference devices Thermal decomposition Tissue Distribution Toxicity Tumors |
| title | Engineering red-emitting multi-functional nanocapsules for magnetic tumour targeting and imaging |
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