Rapid quantification of ruthenium() polypyridyl anti-cancer drugs using a selective ligand dissociation LC-MS/MS method

Research on Ru anti-cancer drugs is on the rise with many complexes in clinical trials. Inductively coupled plasma-mass spectrometry (ICP-MS) has been the standard technique for bioanalytical studies on Ru and Pt complexes in biological media. Tedious ICP-MS methods rely on detecting and quantifying...

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Veröffentlicht in:	Analytical methods 2020-10, Vol.12 (37), p.4517-4525
Hauptverfasser:	Mehanna, Stephanie, Bodman-Smith, Kikki, Daher, Costantine F, Khnayzer, Rony S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Clinical trials Drugs Emission spectroscopy In vivo methods and tests Inductively coupled plasma mass spectrometry Ligands Liquid chromatography Mass spectrometry Mass spectroscopy Optimization Pharmacodynamics Pharmacokinetics Pharmacology Ruthenium Ruthenium compounds Scientific imaging Selectivity
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