Interlaboratory method validation of imaged capillary isoelectric focusing methodology for analysis of recombinant human erythropoietin

Recombinant human erythropoietin (rhEPO) is one of the most important biopharmaceuticals worldwide, with global sales expected to reach US$11.9 billion in 2020. The charge heterogeneity of rhEPO must be monitored throughout the entire production process. Imaged capillary isoelectric focusing (icIEF)...

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Veröffentlicht in:	Analytical methods 2020-08, Vol.12 (3), p.3836-3843
Hauptverfasser:	Li, Xiang, Shi, Xingchang, Qin, Xi, Yu, Lei, Zhou, Yong, Rao, Chunming
Format:	Artikel
Sprache:	eng
Schlagworte:	Electrophoresis, Capillary Erythropoietin Heterogeneity Humans Interlaboratory cooperation Isoelectric Focusing Linearity Recombinant Proteins Reproducibility Reproducibility of Results
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