Bioinspired polynorepinephrine nanoparticles as an efficient vehicle for enhanced drug delivery

An innovative drug delivery vehicle based on polynorepinephrine (PNE) with controllable size modification, high delivery efficacy and low cytotoxicity is presented. Highly monodisperse PNE nanoparticles are fabricated by the autoxidation of norepinephrine monomers in an alkaline water/ethanol mixtur...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-02, Vol.8 (5), p.961-968
Hauptverfasser:	Lu, Zhenzhen, Douek, Alon M, Rozario, Ashley M, Tabor, Rico F, Kaslin, Jan, Follink, Bart, Teo, Boon Mian
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline water Animals Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Autoxidation Biocompatibility Biomimetics Cancer Cancer therapies Cell Proliferation - drug effects Cell Survival - drug effects Chemotherapy Cytotoxicity Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers - chemistry Drug delivery Drug Delivery Systems Drug Screening Assays, Antitumor Embryos Environmental conditions Ethanol HeLa Cells Humans Materials Testing Melanin Microenvironments Molecular Structure Monomers Nanoparticles Nanoparticles - chemistry Norepinephrine Norepinephrine - chemistry Optimization Particle Size pH effects Polymers - chemistry Room temperature Surface Properties Toxicity Tumor Cells, Cultured Tumor microenvironment Tumors Zebrafish Zebrafish - embryology
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