Biodegradable iron-coordinated hollow polydopamine nanospheres for dihydroartemisinin delivery and selectively enhanced therapy in tumor cells

As the semisynthetic derivative and active metabolite of the effective anti-malarial drug artemisinin, dihydroartemisinin (DHA) has been investigated as an emerging therapeutic agent for tumor treatment based on the cytotoxicity of free-radicals originating from interactions with ferrous ions. Meanw...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-10, Vol.7 (4), p.6172-618
Hauptverfasser:	Dong, Liang, Wang, Chao, Zhen, Wenyao, Jia, Xiaodan, An, Shangjie, Xu, Zhiai, Zhang, Wen, Jiang, Xiue
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Artemisinin Biocompatibility Biodegradability Biodegradation Chemical compounds Cytotoxicity Dihydroartemisinin Ferrous ions Free radicals Ions Iron Metabolites Microenvironments Nanospheres Nanotechnology Pharmacology Reactive oxygen species Side effects Stability Therapy Toxicity Tumor cells Tumors
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