Oxime-based 19-nortestosterone-pheophorbide conjugate: bimodal controlled release concept for PDT

Photodynamic therapy has become a feasible direction for the treatment of both malignant and non-malignant diseases. It has been in the spotlight since FDA regulatory approval was granted to several photosensitizers worldwide. Nevertheless, there are still strong limitations in the targeting specifi...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-09, Vol.7 (36), p.5465-5477
Hauptverfasser:	Pavlí ková, Vladimíra, Jurášek, Michal, Rimpelová, Silvie, Záruba, Kamil, Sedlák, David, Šimková, Markéta, Kodr, David, Sta ková, Eliška, Fähnrich, Jan, Rottnerová, Zde ka, Bart n k, Petr, Lap ík, Old ich, Drašar, Pavel, Ruml, Tomáš
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptors Binding Biotechnology Cancer Chemical properties Conjugates Controlled release Endoplasmic reticulum Fluorescence Fluorescence microscopy Localization Medical treatment Menopause Microscopy Mitochondria Nortestosterone Organic chemistry Photodynamic therapy Photosensitization Physicochemical properties Regulatory approval Singlet oxygen Steroids Toxicity Tumor cell lines Tumors
Online-Zugang:	Volltext
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