Self-adhesive photothermal hydrogel films for solar-light assisted wound healing
Hydrogel-based dressings can provide a moist environment for wounds, and have been proven to be beneficial for wound healing. However, preparation of effective hydrogel dressings in a facile yet robust manner still remains a big challenge. Herein, a photo-initiated polymerization method is employed...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-06, Vol.7 (23), p.3644-3651 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Gao, Yujie Du, Hongyao Xie, Zhanjun Li, Miaomiao Zhu, Jinjin Xu, Jingwei Zhang, Lianbin Tao, Juan Zhu, Jintao |
| description | Hydrogel-based dressings can provide a moist environment for wounds, and have been proven to be beneficial for wound healing. However, preparation of effective hydrogel dressings in a facile yet robust manner still remains a big challenge. Herein, a photo-initiated polymerization method is employed to develop a photothermal hydrogel film with self-adhesive properties for accelerated wound healing under solar light irradiation. Such a hydrogel film is obtained by taking advantage of the excellent adhesion of bioinspired polydopamine (PDA) and the great photothermal conversion capability of reduced graphene oxide (rGO) upon solar light irradiation. The formed photothermal hydrogel film could adhere to wounds and convert solar light into heat, warming up the wound locally. The localized temperature enhancement significantly promotes wound healing by reducing the inflammatory response, and enhancing re-epithelialization, angiogenesis, and collagen deposition, presumably correlated with the increased expressions of transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor-A (VEGF-A). This finding demonstrates the great potential of the photothermal hydrogel film for wound healing in clinical or daily applications.
Self-adhesive photothermal hydrogel films can adhere to skin wound and convert solar light into heat, warming up the wound locally and promoting wound repair. |
| doi_str_mv | 10.1039/c9tb00481e |
| format | Article |
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Self-adhesive photothermal hydrogel films can adhere to skin wound and convert solar light into heat, warming up the wound locally and promoting wound repair.</description><subject>Adhesives</subject><subject>Angiogenesis</subject><subject>Collagen</subject><subject>Dressings</subject><subject>Graphene</subject><subject>Growth factors</subject><subject>Hydrogels</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Irradiation</subject><subject>Light irradiation</subject><subject>Photothermal conversion</subject><subject>Polymerization</subject><subject>Transforming growth factor</subject><subject>Transforming growth factor-b1</subject><subject>Vascular endothelial growth factor</subject><subject>Wound healing</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLAzEUhYMoWGo37oWIO2E0mcwjs9RSH1BQsIK7kGdnStqMSUbpvzdaqTvv5l44H-ceDgCnGF1hRJpr2USBUEGxPgCjHJUoq0tMD_c3ejsGkxBWKA3FFSXFCDy_aGsyrlodug8N-9ZFF1vt19zCdqu8W2oLTWfXARrnYXCW-8x2yzZCHkIXolbw0w0bBVvNbbdZnoAjw23Qk989Bq93s8X0IZs_3T9Ob-aZJAWNWS4FrWiJiaIGKVkWtOaSS6OkFqjiTZGiI0FERapc1UIgznNuigabinBKDBmDi51v7937oENkKzf4TXrJ8pzQZI5rmqjLHSW9C8Frw3rfrbnfMozYd2ls2ixuf0qbJfhsB_sg99xfqUk__09nvTLkC5cOdV0</recordid><startdate>20190612</startdate><enddate>20190612</enddate><creator>Gao, Yujie</creator><creator>Du, Hongyao</creator><creator>Xie, Zhanjun</creator><creator>Li, Miaomiao</creator><creator>Zhu, Jinjin</creator><creator>Xu, Jingwei</creator><creator>Zhang, Lianbin</creator><creator>Tao, Juan</creator><creator>Zhu, Jintao</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-8548-1506</orcidid><orcidid>https://orcid.org/0000-0002-8230-3923</orcidid></search><sort><creationdate>20190612</creationdate><title>Self-adhesive photothermal hydrogel films for solar-light assisted wound healing</title><author>Gao, Yujie ; 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B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Yujie</au><au>Du, Hongyao</au><au>Xie, Zhanjun</au><au>Li, Miaomiao</au><au>Zhu, Jinjin</au><au>Xu, Jingwei</au><au>Zhang, Lianbin</au><au>Tao, Juan</au><au>Zhu, Jintao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-adhesive photothermal hydrogel films for solar-light assisted wound healing</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><date>2019-06-12</date><risdate>2019</risdate><volume>7</volume><issue>23</issue><spage>3644</spage><epage>3651</epage><pages>3644-3651</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>Hydrogel-based dressings can provide a moist environment for wounds, and have been proven to be beneficial for wound healing. However, preparation of effective hydrogel dressings in a facile yet robust manner still remains a big challenge. Herein, a photo-initiated polymerization method is employed to develop a photothermal hydrogel film with self-adhesive properties for accelerated wound healing under solar light irradiation. Such a hydrogel film is obtained by taking advantage of the excellent adhesion of bioinspired polydopamine (PDA) and the great photothermal conversion capability of reduced graphene oxide (rGO) upon solar light irradiation. The formed photothermal hydrogel film could adhere to wounds and convert solar light into heat, warming up the wound locally. The localized temperature enhancement significantly promotes wound healing by reducing the inflammatory response, and enhancing re-epithelialization, angiogenesis, and collagen deposition, presumably correlated with the increased expressions of transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor-A (VEGF-A). This finding demonstrates the great potential of the photothermal hydrogel film for wound healing in clinical or daily applications.
Self-adhesive photothermal hydrogel films can adhere to skin wound and convert solar light into heat, warming up the wound locally and promoting wound repair.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/c9tb00481e</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8548-1506</orcidid><orcidid>https://orcid.org/0000-0002-8230-3923</orcidid></addata></record> |
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| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2019-06, Vol.7 (23), p.3644-3651 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Adhesives Angiogenesis Collagen Dressings Graphene Growth factors Hydrogels Inflammation Inflammatory response Irradiation Light irradiation Photothermal conversion Polymerization Transforming growth factor Transforming growth factor-b1 Vascular endothelial growth factor Wound healing |
| title | Self-adhesive photothermal hydrogel films for solar-light assisted wound healing |
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