A class of Pt() triple-prodrugs targeting nucleic acids, thymidylate synthases and histone deacetylases

A series of Pt( iv ) compounds comprising a special short-chain fatty acid (a histone deacetylase inhibitor) and 5-FU (a thymidylate synthase inhibitor) were prepared and bio-evaluated for their antiproliferative activity using the MTT assay. The assembled compounds 11-15 , as triple-prodrugs, exhib...

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Veröffentlicht in:	Inorganic chemistry frontiers 2020-03, Vol.7 (5), p.122-1228
Hauptverfasser:	Ding, Xiao-Jing, Zhang, Ran, Liu, Rui-Ping, Song, Xue-Qing, Qiao, Xin, Xie, Cheng-Zhi, Zhao, Xiu-He, Xu, Jing-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Apoptosis Cell cycle Chemical compounds Cytotoxicity Damage accumulation Drugs Endothelial cells Fatty acids Histones Inhibitors Inorganic chemistry Nucleic acids Time dependence Toxicity testing
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