Clickable styryl dyes for fluorescence labeling of pyrrolidinyl PNA probes for the detection of base mutations in DNA

Fluorescent hybridization probes are important tools for rapid, specific and sensitive analysis of genetic mutations. In this work, we synthesized novel alkyne-modified styryl dyes for conjugation with pyrrolidinyl peptide nucleic acid (acpcPNA) by click chemistry for the development of hybridizatio...

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Veröffentlicht in:	Organic & biomolecular chemistry 2019-12, Vol.17 (45), p.9712-9725
Hauptverfasser:	Ditmangklo, Boonsong, Taechalertpaisarn, Jaru, Siriwong, Khatcharin, Vilaivan, Tirayut
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Alkynes Aqueous solutions Chemical synthesis Click Chemistry Complementary DNA Conjugation Defects Deoxyribonucleic acid Diagnostic systems DNA DNA - analysis DNA - genetics DNA probes DNA Probes - chemistry Dyes Fluorescence Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent indicators Gene deletion Genetic analysis Hybridization Insertion Molecular Structure Mutation Nucleotides Organic chemistry Peptide nucleic acids Peptide Nucleic Acids - chemistry Polymorphism Probes Pyrrolidines - chemistry Reductive alkylation Single-nucleotide polymorphism Styrenes - chemical synthesis Styrenes - chemistry
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