The catalytic asymmetric synthesis of CF 3 -containing spiro-oxindole-pyrrolidine-pyrazolone compounds through squaramide-catalyzed 1,3-dipolar cycloaddition
Pharmaceutically important compounds were synthesized through the organocatalytic 1,3-dipolar cycloaddition reaction. In the presence of a cinchonine-derived squaramide catalyst, the cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with α,β-unsaturated pyrazolones gave a spiro-pyrrolidine-lin...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2019-06, Vol.17 (22), p.5514-5519 |
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| container_issue | 22 |
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| container_title | Organic & biomolecular chemistry |
| container_volume | 17 |
| creator | Wang, Cui Wen, Dongwa Chen, Hui Deng, Yabo Liu, Xueting Liu, Xin Wang, Li Gao, Fengyun Guo, Yifei Sun, Mengmeng Wang, Kairong Yan, Wenjin |
| description | Pharmaceutically important compounds were synthesized through the organocatalytic 1,3-dipolar cycloaddition reaction. In the presence of a cinchonine-derived squaramide catalyst, the cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with α,β-unsaturated pyrazolones gave a spiro-pyrrolidine-linked oxindole and pyrazolone compound bearing four consecutive stereocenters and two vicinal spiroquaternary chiral centers, in excellent yields and stereoselectivities. |
| doi_str_mv | 10.1039/C9OB00720B |
| format | Article |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| title | The catalytic asymmetric synthesis of CF 3 -containing spiro-oxindole-pyrrolidine-pyrazolone compounds through squaramide-catalyzed 1,3-dipolar cycloaddition |
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