One-pot synthesis of Ln 3+ -doped porous BiF 3 @PAA nanospheres for temperature sensing and pH-responsive drug delivery guided by CT imaging

The design and synthesis of responsive inorganic nanocapsules have attracted intensive research interest in cancer treatment. The combination of non-invasive diagnosis and chemotherapy into a single theranostic nanoplatform is prospective in the biomedical field. In this work, a polyacrylic acid (PA...

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Veröffentlicht in:Nanoscale 2020-01, Vol.12 (2), p.695-702
Hauptverfasser: Zhao, Shuang, Tian, Rongrong, Shao, Baiqi, Feng, Yang, Yuan, Senwen, Dong, Langping, Zhang, Liang, Wang, Zhenxin, You, Hongpeng
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Sprache:eng
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Zusammenfassung:The design and synthesis of responsive inorganic nanocapsules have attracted intensive research interest in cancer treatment. The combination of non-invasive diagnosis and chemotherapy into a single theranostic nanoplatform is prospective in the biomedical field. In this work, a polyacrylic acid (PAA)-functionalized porous BiF :Yb,Er nanocarrier was constructed via a straightforward one-pot solvothermal strategy. Compared with the undoped BiF sub-microspheres, the lanthanide ion (Ln ) doping endowed the BiF material with a smaller size and increased BET specific surface area and pore volume, which make it suitable as a drug carrier. It was found that the synthesized nanomaterial could effectively relieve the side effects of doxorubicin (DOX) and exhibited pH-dependent DOX loading and release. Its satisfactory biocompatibility and efficient tumor inhibition were emphasized by a series of in vitro/in vivo experiments. In addition, the synthesized nanomaterial exhibited favorable CT contrast efficacy due to the excellent X-ray attenuation coefficient of Bi. Moreover, characteristic upconversion luminescence and temperature sensing in a wide temperature range were realized over the synthesized BiF :Yb,Er sample. Therefore, carboxyl-functionalized BiF :Yb,Er can be expected to be an ideal candidate in the fabrication of temperature sensing and multifunctional theranostic nanoplatforms.
ISSN:2040-3364
2040-3372
DOI:10.1039/c9nr09401f