One-pot synthesis of Ln 3+ -doped porous BiF 3 @PAA nanospheres for temperature sensing and pH-responsive drug delivery guided by CT imaging
The design and synthesis of responsive inorganic nanocapsules have attracted intensive research interest in cancer treatment. The combination of non-invasive diagnosis and chemotherapy into a single theranostic nanoplatform is prospective in the biomedical field. In this work, a polyacrylic acid (PA...
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Veröffentlicht in: | Nanoscale 2020-01, Vol.12 (2), p.695-702 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The design and synthesis of responsive inorganic nanocapsules have attracted intensive research interest in cancer treatment. The combination of non-invasive diagnosis and chemotherapy into a single theranostic nanoplatform is prospective in the biomedical field. In this work, a polyacrylic acid (PAA)-functionalized porous BiF
:Yb,Er nanocarrier was constructed via a straightforward one-pot solvothermal strategy. Compared with the undoped BiF
sub-microspheres, the lanthanide ion (Ln
) doping endowed the BiF
material with a smaller size and increased BET specific surface area and pore volume, which make it suitable as a drug carrier. It was found that the synthesized nanomaterial could effectively relieve the side effects of doxorubicin (DOX) and exhibited pH-dependent DOX loading and release. Its satisfactory biocompatibility and efficient tumor inhibition were emphasized by a series of in vitro/in vivo experiments. In addition, the synthesized nanomaterial exhibited favorable CT contrast efficacy due to the excellent X-ray attenuation coefficient of Bi. Moreover, characteristic upconversion luminescence and temperature sensing in a wide temperature range were realized over the synthesized BiF
:Yb,Er sample. Therefore, carboxyl-functionalized BiF
:Yb,Er can be expected to be an ideal candidate in the fabrication of temperature sensing and multifunctional theranostic nanoplatforms. |
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ISSN: | 2040-3364 2040-3372 |
DOI: | 10.1039/c9nr09401f |